Natural variation and CRISPR/Cas9 gene editing demonstrate the potential for a group VII ethylene response factor HvERF62 in regulating barley (Hordeum vulgare L.) waterlogging tolerance.

Waterlogging stress is a serious problem all over the world, which inhibits plant growth and development, and even leads to plant death in severe circumstances. Ethylene-responsive VII transcription factor (ERFVII) is a key factor regulating plant waterlogging tolerance. In this study, a major QTL conferring chlorophyll content under waterlogging stress was detected on chromosome 4H through GWAS using a natural population.

CPA4 overexpression correlates with poor prognosis and tumor progression in endometrial cancer.

Background: The rise in endometrial cancer rates globally calls for advanced diagnostic methods and new biomarkers. CPA4, known for its role in cancer development, has not yet been studied in relation to endometrial cancer, making it a promising research avenue.

Methods: We analyzed CPA4's mRNA expression using data from TCGA and GEO databases and validated these findings with 116 clinical samples through immunohistochemical analysis.

Traceability of septic shock caused by phocaeicola vulgatus: a rare case report.

Background: Phocaeicola vulgatus (P.vulgatus) is a member of Bacteroides fragilis Group(BFG). Septic shock caused by P.

Research on computing task scheduling method for distributed heterogeneous parallel systems.

With the explosive growth of terminal devices, scheduling massive parallel task streams has become a core challenge for distributed platforms. For computing resource providers, enhancing reliability, shortening response times, and reducing costs are significant challenges, particularly in achieving energy efficiency through scheduling to realize green computing. This paper investigates the heterogeneous parallel task flow scheduling problem to minimize system energy consumption under response time constraints.

Genetic deletion of G protein-coupled receptor 56 aggravates traumatic brain injury through the microglial CCL3/4/5 upregulation targeted to CCR5.

Traumatic brain injury (TBI) is a significant global health concern that often results in death or disability, and effective pharmacological treatments are lacking. G protein-coupled receptor 56 (GPR56), a potential drug target, is crucial for neuronal and glial cell function and therefore plays important roles in various neurological diseases. Here, we investigated the potential role and mechanism of GPR56 in TBI-related damage to gain new insights into the pharmacological treatment of TBI.

A novel self-ratiometric fluorescent sensor of sodium alginate hydrogel bead doping with coumarin derivative with extremely acidic pH visual monitoring of fruit juice freshness.

The slight acidic pH changes during food storage and transportation are often difficult to detect in a timely and accurate manner. There is also an urgent need to establish a portable, accurate, and low interference detection method for real-time monitoring of the quality changes of fresh juice that already has its own color. In this paper, a self-ratiometric fluorescent sensor (DCCA/SA bead) was prepared by combining a modified coumarin and sodium alginate (SA), and was used for the extreme pH monitoring of fluorescent by naked eye colorimetry.

Functional modification of edible film based on egg white protein and its application in food preservation: A review.

Based on the urgent need for environmental protection, traditional petroleum-based packaging materials are gradually being replaced by non-toxic and biodegradable biopolymer packaging materials such as proteins, polysaccharides and lipids. Among them, egg white protein (EWP) has been widely concerned because of its excellent gel film forming properties and high nutritional value. EWP film has the advantages of high mechanical strength, good stability, high transparency, controllable cost, good compatibility with human tissue, etc.

Emerging importance of m6A modification in liver cancer and its potential therapeutic role.

Liver cancer refers to malignant tumors that form in the liver and is usually divided into several types, the most common of which is hepatocellular carcinoma (HCC), which originates in liver cells. Other rare types of liver cancer include intrahepatic cholangiocarcinoma (iCCA). m6A modification is a chemical modification of RNA that usually manifests as the addition of a methyl group to adenine in the RNA molecule to form N6-methyladenosine.

Prodrug-designed nanocarrier co-delivering chemotherapeutic and vascular disrupting agents with exceptionally high drug loading capacity.

Chemotherapy remains a vital component of cancer treatment, with combination therapy widely used in clinical practice to overcome the limitations of single-drug administration. However, challenges persist including pharmacokinetic discrepancies among different pharmaceutical agents, and insufficient synergistic efficiency in small-molecule drug combinations. There is an urgent need to develop more efficient combination therapy strategies.

USP14 inhibits sensitization-mediated degradation of KDM4D to epigenetically regulate dendritic cell tolerogenic capacity and mitigates airway allergy.

Numerous immune disorders are caused by the dysfunction of dendritic cells (DC). The mechanism has not been fully comprehended yet. This research is designed to regulate the epigenetic status of lysine-specific demethylase 4D (KDM4D) to enhance DC's immune tolerogenic capacity.

Efficient selectivity of dual-metal intermediate structure in metal-organic frameworks-based photocatalyst for customized the pathway of CO reduction to CO.

The capture and utilization of CO are critical for protecting the environment and ensuring the sustainable development of society. Given the challenges in separating multiple C1 products (CO, CH etc.) with similar reduction potentials, achieving high selectivity for a single reduction product while maintaining high conversion efficiency is essential.

A simple post-processing approach induced Interface recombination to construct hollow cubic-shape Prussian blue analogs for biosensing and degradation of aflatoxins B1.

Multifunctional Prussian blue analogs (PBAs) have received extensive attention in the detection and degradation of food hazards. However, the development of new structural adjustment strategies to further improve their performance remains a huge challenge. Herein, the "interface recombination" post-processing approach was established to regulate the structure of PBAs using a microwave-assisted solvothermal method combined with acid etching.

Pan-cancer bioinformatics analysis of TIPRL in human tumors.

Introduction: The TOR signaling pathway regulator-like (TIPRL) gene plays a multifaceted role in cancer, yet its pan-cancer profile remains underexplored. This study investigates TIPRL expression across multiple cancers and its associations with survival, genetic alterations, immune infiltration, and functional pathways, providing insights into TIPRL's role as a potential prognostic and therapeutic target.

Methods: TIPRL expression and prognostic significance across tumor types were analyzed using TCGA_GTEx and CPTAC data in R software and platforms like GEPIA2 and UALCAN.

In Situ Growth of Highly Dispersed TiO in Covalent Organic Frameworks for Photocatalytic H Evolution.

Titanium dioxide (TiO) has the disadvantages of being difficult to excite and easily agglomerating in use. The imine-linked covalent organic frameworks (COFs) have shown various excellent properties in diverse fields, but the drawbacks such as monofunctionality and poor light-corrosion resistance are the problems that need to be improved in photocatalytic applications. In this paper, the imine-linked COF (COF-Im) was prepared and then transformed into a quinoline-based COF (COF-Qui) by an aza-Diels-Alder reaction, which successfully improved the light absorption and stability of the COFs.

Metabolic regulation of amino acids provides an important basis for individualized nutritional therapy for patients with gastric cancer during the perioperative period.

Background: Gastric cancer is a prevalent malignancy worldwide, with early detection and treatment being vital to improving patient outcomes. Amino acids (AAs), as essential regulators in cancer cell metabolism, are implicated in the progression and response to treatment.

Methods: This study aimed to investigate the dynamics of plasma AA levels in gastric cancer patients preoperatively, postoperatively, and following nutritional intervention, comparing them to healthy controls.

The interdependence of mid-trimester blood pressure and glucose levels in shaping fetal growth and neonatal outcomes: implications for risk-benefit assessment and co-management.

Background: Maternal hypertension and hyperglycemia are closely related but have distinct impacts on fetal growth and are managed independently. How the interdependence of blood pressure (BP) and glucose levels quantitatively influences risk patterns for abnormal fetal growth and neonatal complications remains unexplored.

Methods: Maternal BP and fasting plasma glucose (FPG) levels were measured between 20 and 28 weeks of gestation in a cohort including 56,881 singleton pregnancies.

The differences in intestinal flora and metabolites between H-type hypertension and non-H-type hypertension.

Objective: In order to explore the differences in gut microbiota and their metabolites between patients with H-type hypertension and non-H-type hypertension.

Method: Our study included 100 hypertensive patients from the Department of Cardiology at Shaoxing Second Hospital, with 51 patients having H-type hypertension (H group) and 49 having non-H-type hypertension (non-H group). Blood samples were collected for clinical and metabolite testing, and fecal samples were collected for 16 S rRNA sequencing and metabolite testing.

Maternal high-fat diet exacerbates atherosclerosis development in offspring through epigenetic memory.

Maternal exposure to a Western-type diet (WD) increases the susceptibility of adult offspring to atherosclerosis, partly because fetal endothelial cells (ECs) become dysfunctional and inflamed due to risk factors transmitted via maternal-fetal blood exchange. However, the underlying mechanisms remain unclear. Here we show that maternal WD accelerates atherogenesis in adult offspring mice by regulating chromatin dynamics through activator protein-1 (AP-1) in aortic ECs, inducing inflammatory memory at the chromatin level.

Overexpression of miR-99a promoted expansion and suppressed differentiation of hematopoietic stem/progenitor cells.

MicroRNAs (miRNAs) are a class of non-coding RNAs involved in a variety of pathophysiological processes. We have previously reported that the abnormally high expression of miR-99a is associated with drug resistance and poor prognosis in acute myeloid leukemia. However, the impact of miR-99a on normal hematopoiesis is not well understood.

Effects of wakeful rest on memory consolidation: A systematic review and meta-analysis.

Individuals spend roughly two-thirds of their day awake, with about half of that time in an offline state. This period may appear unproductive, potentially leading to perceived inefficiency. However, this period appears to be an essential component of our daily lives.

Effect of environmental conditions on the survival and transfer of Enterococcus faecium between wheat flour and selected contact surfaces.

Low moisture food safety issues are frequently associated with Salmonella and its cross-contamination. As a non-pathogenic surrogate, the survival levels and transfer of Enterococcus faecium NRRL B-2354 on stainless steel (SS) and polypropylene (PP) coupons were investigated. The transfer rates of E.

Development and evaluation of biphenyl-based small-molecule radiotracers for PET imaging of PD-L1 in tumor.

Accurate identification of programmed cell death ligand 1 (PD-L1) expression is crucial for anti-tumor immunotherapy. However, the heterogeneity of PD-L1 expression in tumors makes it challenging to detect by immunohistochemistry. In this study, we developed two novel PD-L1 small-molecule PET tracers, [F]LGT-1 and [F]LGT-2, to enable the non-invasive and precise measurement of PD-L1 expression in tumors through PET imaging.

Ecoenzymatic stoichiometry reveals that increasing altitude exacerbates soil microbial phosphorus limitation in alpine grassland ecosystems in Xinjiang.

Ecoenzymatic stoichiometry is an essential method for predicting material cycling, nutrient limitations, and balance within ecosystems, provides new insights into microbial metabolic mechanisms. However, the status and drivers of soil microbial nutrient limitation in alpine grasslands remain unclear. In this paper, soil samples were collected along a seven-altitude gradient (2400 m to 3000 m).