Transitions to crop residue burning have multiple antecedents in Eastern India.

Unlabelled: Far removed from the agricultural fire "hotspots" of Northwestern India, rice residue burning is on the rise in Eastern India with implications for regional air quality and agricultural sustainability. The underlying drivers contributing to the increase in burning have been linked to the adoption of mechanized (combine) harvesting but, in general, are inadequately understood. We hypothesize that the adoption of burning as a management practice results from a set of socio-technical interactions rather than emerging from a single factor.

Leveraging men's education as an effective pathway for improving diet quality: Evidence from rural India.

Investing in nutrition sensitive sectors such as education can be an effective strategy for combatting malnutrition. In this paper we analyze the role that men's education plays in determining dietary diversity outcomes using primary data from 3600 households across four districts of India. Dietary diversity scores were calculated to reflect the quality of food intake, for households and women.

High-Dose Acetaminophen with -acetylcysteine Rescue Inhibits M2 Polarization of Tumor-Associated Macrophages.

High-dose acetaminophen (AAP) with -acetylcysteine (NAC) rescue is among the few treatments that has shown activity in phase I trials without achieving dose-limiting toxicity that has not progressed to evaluation in later line studies. While the anti-tumor effects of AAP/NAC appear not to be mediated by glutathione depletion and free radical injury, the mechanism of anti-tumor effects of AAP/NAC has not been definitively characterized. In vitro, the effects of AAP/NAC were evaluated on bone marrow derived macrophages.

COVID-19 and women's nutrition security: panel data evidence from rural India.

In response to the COVID-19 pandemic, India implemented a stringent nationwide lockdown. Although food value chains and allied activities were exempted from the lockdown, there were widespread disruptions in food access and availability. Using two panel-datasets, we distinguish the pandemic's impact on non-staples versus staples in relation to household food availability and women's diet diversity at the national, state, and district levels in four economically backward districts of Uttar Pradesh (Maharajganj), Bihar (Munger), and Odisha (Kandhamal and Kalahandi).

Food loss of perishable produce from farm to retail: evidence from tomato supply chains in South India.

Background: Reducing food loss and waste (FLW) may narrow gaps between fruit and vegetable production and recommended intake. However, FLW estimates are inconsistent due to varying estimation methods.

Objectives: Using multiple estimation approaches, we examined the extent and determinants of FLW along tomato supply chains in South India, from farm to retail.

Spatiotemporal assessment of post-harvest mycotoxin contamination in rural North Indian food systems.

The spatiotemporal trends in aflatoxin B1 (AFB1), fumonisin B1 (FB1), and deoxynivalenol (DON) accumulation were analyzed in a range of food commodities (maize, groundnut, pearl millet, rice, and wheat) in village settings in Unnao, Uttar Pradesh, India. Samples (n = 1549) were collected across six communities and six time points spanning a calendar year and were analyzed for mycotoxins using enzyme-linked immunosorbent assays. AFB1 and FB1 were common across surveyed villages, with moderate to high detection rates (45-75%) observed across commodities.

Transitioning to an obese India: Demographic and structural determinants of the rapid rise in overweight incidence.

India, which has long suffered from undernutrition, has seen a rapid rise in overweight incidence in the last decade and a half. These changes are characterized by significant within-country differences in overweight incidence that vary by gender and regional development levels. In this paper, we provide an integrative framework, linking the income-gradient hypothesis of obesity with biological, obesogenic, and environmental factors to provide an explanation on the emergence of within-country differences in overweight patterns.

Seasonal time trade-offs and nutrition outcomes for women in agriculture: Evidence from rural India.

Women in agriculture are involved in agricultural activities and are solely responsible for household-level unpaid work. They face severe time trade-offs between agricultural and household activities across crop seasons. Recent literature suggests that these time trade-offs may negatively impact their nutrition.

Ground truthing the cost of achieving the EAT lancet recommended diets: Evidence from rural India.

In this paper, we quantify the divergence in the cost of current diets as compared to EAT Lancet recommendations at the subnational-level in India. We use primary data on food prices and household food purchases, and secondary data on food expenditures for a period of 12 months in 2018-19. The cost of the EAT Lancet dietary recommendations for rural India ranges between $3.

High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity.

High-dose acetaminophen (AAP) with delayed rescue using n-acetylcysteine (NAC), the FDA-approved antidote to AAP overdose, has demonstrated promising antitumor efficacy in early phase clinical trials. However, the mechanism of action (MOA) of AAP's anticancer effects remains elusive. Using clinically relevant AAP concentrations, we evaluated cancer stem cell (CSC) phenotype in vitro and in vivo in lung cancer and melanoma cells with diverse driver mutations.

Effects of short birth spacing on birth-order differences in child stunting: Evidence from India.

Do firstborn children have a height advantage? Empirical findings have found mostly that, yes, second or higher-order children often lag behind firstborns in height outcomes, especially in developing countries. However, empirical investigations of birth-order effects on child height overlook the potential impact that birth spacing can have. We provide an explanation for the negative birth-order effect on stunting outcomes for young Indian children and show it is driven by short preceding-birth spacing.

Exploring aflatoxin contamination and household-level exposure risk in diverse Indian food systems.

The present study sought to identify household risk factors associated with aflatoxin contamination within and across diverse Indian food systems and to evaluate their utility in risk modeling. Samples (n = 595) of cereals, pulses, and oil seeds were collected from 160 households across four diverse districts of India and analyzed for aflatoxin B1 using enzyme-linked immunosorbent assay (ELISA). Demographic information, food and cropping systems, food management behaviors, and storage environments were profiled for each household.

Pandemics and food systems - towards a proactive food safety approach to disease prevention & management.

Recent large-scale pandemics such as the covid19, H1N1, Swine flu, Ebola and the Nipah virus, which impacted human health and livelihoods, have come about due to inadequate food systems safeguards to detect, trace and eliminate threats arising from zoonotic diseases. Such diseases are transmitted to humans through their interaction with animals in the food value chain including through the consumption of bush meat. Climate change has also facilitated the emergence of new zoonotic diseases.

A research vision for food systems in the 2020s: Defying the status quo.

•Research and science should not only inform food and environmental policy but should be adopted and mainstreamed into actions at all levels.•Food systems are faced with grander and interconnected challenges and constraints that bring about new research questions.•Research has a vital role in charting a positive and sustainable direction for global food security, nutrition, and health.

Are Women in Rural India Really Consuming a Less Diverse Diet?

Background: It is widely considered that women have less diverse diets than other household members. However, it has been challenging to establish this empirically since women's diet diversity is measured differently from that of other household members.

Objective: In this article, we compare women's dietary diversity with that of their respective households and thereby generate a measure of "dietary gap.

Market Access, Production Diversity, and Diet Diversity: Evidence From India.

Background: Recent literature, largely from Africa, shows mixed effects of own-production on diet diversity. However, the role of own-production, relative to markets, in influencing food consumption becomes more pronounced as market integration increases.

Objective: This paper investigates the relative importance of two factors - production diversity and household market integration - for the intake of a nutritious diet by women and households in rural India.

Nutritional outcomes of empowerment and market integration for women in rural India.

Over half of all women of reproductive age are affected by anaemia in India. In this paper we study the role that both household market integration and women's empowerment in agriculture can play in determining women's dietary diversity. Our analysis is based on primary data from 3600 households across India on agriculture, nutrition and anthropometric outcomes.

Adapting the Women's empowerment in agriculture index to specific country context: Insights and critiques from fieldwork in India.

The Women's Empowerment in Agriculture Index (WEAI) is a direct, multi-dimensional measure of women's access to resources and decision-making in various domains of agriculture. However, several challenges characterize its use: adaptation of questionnaires to local agricultural contexts, modifications to index construction once underlying activities and adequacy thresholds are modified, and sensitivity analysis. In this paper, we address such challenges based on our experience of adapting and using the WEAI across 3600 households in India.

Understanding nutritional outcomes through gendered analysis of time-use patterns in semi-arid India.

The objective of this paper is to understand individual nutritional outcomes through an examination of gendered time use patterns. The analysis of the data from eight villages in the Semi-Arid Tropics (SAT), India confirm previous conclusions about the gendered influence of agricultural interventions, especially time demands on the rural poor. Agricultural interventions in the harsh, drought-prone environment of the SAT tend to increase the time burden on women.

The role of agriculture in women's nutrition: Empirical evidence from India.

In this paper, we establish a statistically important relationship between household agricultural income and women's BMI using a five-year panel dataset of rural households drawn from 18 villages across five Indian states. Using within household variation over time, we estimate both the extent to which short-term changes in agricultural income are associated with short-term changes in BMI, and the effect of agricultural income growth on BMI growth over a longer term. Over the longer term, and for the group of households that regularly farm, we find a 10 percentage point agricultural income growth to be associated with a 0.

Agriculture, health, and wealth convergence: bridging traditional food systems and modern agribusiness solutions.

The causes of many vexing challenges facing 21st-century society are at the nexus of systems involved in agriculture, health and wealth production, consumption, and distribution. Using food as a test bed, and on the basis of emerging roadmaps that set achievable objectives over a 1- to 3-year horizon, we introduce this special feature with convergence thinking and practice at its core. Specifically, we discuss academic papers structured around four themes: (1) evidence for a need for convergence and underlying mechanisms at the individual and societal levels; (2) strategy for mainstreaming convergence as a driver of business engagement and innovation; (3) convergence in policy and governance; (4) convergence in metrics and methods.

Mainstreaming nutrition metrics in household surveys--toward a multidisciplinary convergence of data systems.

Since the 2008 food price crisis, food and nutrition security are back on the global development agenda, with particular emphasis on agricultural pathways toward improved nutrition. Parallel efforts are being promoted to improve the data and metrics for monitoring progress toward positive nutritional outcomes, especially for women and children. Despite the increased investment in tracking nutritional outcomes, these efforts are often made in silos, which create challenges for integrating nutritional data with other sectoral data, such as those related to agriculture.

Toward an integrated approach to nutritional quality, environmental sustainability, and economic viability: research and measurement gaps.

Nutrition is affected by numerous environmental and societal causes. This paper starts with a simple framework based on three domains: nutritional quality, economic viability, and environmental sustainability, and calls for an integrated approach in research to simultaneously account for all three. It highlights limitations in the current understanding of each domain, and how they influence one another.