Publications by authors named "Ping-Yang Hong"
Purpose: This study aimed to elucidate the causal relationship between Obstructive Sleep Apnea (OSA) and Chronic Respiratory Diseases (CRDs), employing Mendelian Randomization (MR) to overcome limitations inherent in observational studies.
Methods: Utilizing a two-sample MR approach, this study analyzed genetic variants as instrumental variables to investigate the causal link between OSA and various CRDs, including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, and idiopathic pulmonary fibrosis (IPF). Data were sourced from the FinnGen Consortium (OSA, n = 375,657) and UK Biobank, focusing on genome-wide associations between single-nucleotide polymorphisms (SNPs) and the diseases.
Purpose: This study aims to assess the causal relationship between Obstructive Sleep Apnea (OSA), dyslipidemia, and osteoporosis using Mendelian Randomization (MR) techniques.
Methods: Utilizing a two-sample MR approach, the study examines the causal relationship between dyslipidemia and osteoporosis. Multivariable MR analyses were used to test the independence of the causal association of dyslipidemia with OSA.
Article Synopsis
- Elderly people who inhale foreign objects into their airways often show unusual symptoms, making it hard for doctors to diagnose them correctly.
- In a study of older patients, most had common symptoms like cough and difficulty breathing, and many foreign objects were food items, especially in the left lung.
- The doctors achieved a high success rate (96.7%) in removing these objects with a bronchoscope, but some patients needed special techniques or more than one procedure for removal.
Purpose: Our investigation utilized a two-sample Mendelian randomization approach to explore the ambiguous bidirectional relationship between Chronic Obstructive Pulmonary Disease (COPD) and depression, furthering insights from existing observational studies.
Methods: In this study, we conducted a bidirectional Mendelian randomization using genome-wide association studies (GWAS) datasets. We initially analyzed depression data from the Psychiatric Genomics Consortium and the UK Biobank (n = 500,199), alongside COPD data from the FinnGen Consortium (n = 329,552).
Purpose: We studied the functions of sodium tanshinone IIA sulfonate (TSA) in inducing tumor growth in obstructive sleep apnea (OSA)-mimicking intermittent hypoxia (IH) xenograft mice and the underlying potential molecular mechanism.
Methods: RNA sequencing was conducted to screen the differentially expressed microRNAs in cell lines exposed to IH with or without TSA treatment. As part of the 5-week study, we treated xenograft mice with 8-h IH once daily.
Gorham-Stout syndrome: A chylothorax disease with bony destruction: A case report.
Medicine (Baltimore)
December 2022
Article Synopsis
- - Gorham-Stout syndrome is a rare and serious condition that leads to painful tumor-like lesions and significant bone loss, resulting in unfavorable outcomes, especially when affecting the spine or causing fluid buildup in the chest.
- - A 67-year-old man experienced severe chest tightness and shortness of breath, which was linked to hydrothorax and multiple osteolytic lesions revealed by imaging tests.
- - Treatment involved dietary changes, angiography, and a medication called zoledronic acid, which successfully resolved the patient's symptoms, highlighting the need for thorough evaluation in similar cases.
In patients with coronavirus disease 2019 (COVID-19), anticoagulation was suggested as a mitigating strategy. However, little research has been conducted on the adverse consequences of anticoagulant medication. This study aimed to investigate the adverse effect of low molecular weight heparin (LMWH) on hemoglobin fall in COVID-19 treatment.
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