Publications by authors named "Ping-Xi Xiao"
Cichoric acid (CA), a widely utilized polyphenolic compound in medicine, has garnered significant attention due to its potential health benefits. Sepsis-induced acute kidney disease (AKI) is related with an elevated risk of end-stage kidney disease (ESKD). However, it remains unclear whether CA provides protection against septic AKI.
View Article and Find Full Text PDFBackground: Sepsis-related cardiac dysfunction is believed to be a primary cause of high morbidity and mortality. Metabolic reprogramming is closely linked to NLRP3 inflammasome activation and dysregulated glycolysis in activated macrophages, leading to inflammatory responses in septic cardiomyopathy. Succinate dehydrogenase (SDH) and succinate play critical roles in the progression of metabolic reprogramming in macrophages.
View Article and Find Full Text PDFBackground: Deep vein thrombosis (DVT) with its major complication, pulmonary embolism, is a global health problem. Endothelial dysfunction is involved in the pathogenesis of DVT. We have previously demonstrated that endothelial specific deletion of Brahma-related gene 1 (BRG1) ameliorates atherosclerosis and aneurysm in animal models.
View Article and Find Full Text PDFSubclavian steal syndrome associated with Sjogren's syndrome: A case report.
World J Clin Cases
September 2021
Background: Subclavian steal syndrome (SSS) caused by Sjogren's syndrome is rare, especially for elderly patients with risk factors for atherosclerosis. The current report presents the uncommon etiology and treatment of SSS, aiming to improve doctor's clinical experience.
Case Summary: A 69-year-old man was diagnosed with hypertension and acute cerebral infarction presenting with left upper limb weakness and pain even gradually aggravating to left limb hemiplegia 30 years ago.
Article Synopsis
- Current guidelines recommend 12 months of dual antiplatelet therapy (DAPT) for acute coronary syndrome (ACS) patients after drug-eluting stent (DES) implantation, but recent studies suggest that 3 months of DAPT followed by ticagrelor alone might also be effective and safe.
- The IVUS-ACS and ULTIMATE-DAPT trial aims to compare the safety and effectiveness of IVUS-guided versus angiography-guided DES implantation and to evaluate the impact of ticagrelor monotherapy versus ticagrelor plus aspirin on bleeding risks and major adverse cardiovascular events over a year following the procedure.
- The study will involve 3,486 ACS patients who
Background: There is a paucity of evidence regarding the association between obstructive sleep apnea (OSA) and patients undergoing percutaneous coronary intervention (PCI) for coronary artery disease. We sought to investigate whether OSA affects the clinical outcomes of patients undergoing PCI.
Patients And Methods: All enrolled individuals treated with PCI were evaluated for OSA by polysomnography.
Background: The importance of intravascular ultrasound (IVUS)-guided stenting of the unprotected left main coronary artery (ULMCA) remains controversial and has not been fully studied in the subset of patients with ULMCA. This study evaluated the clinical outcome of IVUS-guided stenting using a drug-eluting stent for ULMCA.
Methods: A total of 1,016 consecutive patients with ULMCA stenosis who underwent drug-eluting stent implantation from January 2006 to December 2011 were prospectively registered.