Publications by authors named "Ping-Tao Tseng"
Hearing impairment in patients with rheumatoid arthritis has been underestimated for decades. Rheumatoid arthritis can affect both the middle ear (specifically, the incudomalleolar and incudostapedial joints) and inner ear (including the cochlea and acoustic nerve) simultaneously. Despite ongoing research, consensus on effective treatments for hearing impairment in these patients remains elusive.
View Article and Find Full Text PDFAnti-phospholipid syndrome (APS) has emerged as a significant issue in autoimmune diseases over recent decades. Its hallmark feature is thromboembolic events, potentially affecting any vascularized area including the microcirculation of the inner ear. Since the first case report of APS-related audiovestibular dysfunction described in 1993, numerous reports have explored the association between APS-related antibodies and audiovestibular dysfunction.
View Article and Find Full Text PDFImportance: Viloxazine is a novel nonstimulant medication approved for the treatment of attention-deficit/hyperactivity disorder (ADHD).
Objectives: To investigate the whether viloxazine is associated with effective and acceptable outcomes when treating children and adolescents with ADHD and to evaluate these outcomes' associations with viloxazine doses and duration of treatment.
Data Sources: The MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, PsycINFO, and ClinicalTrial.
Article Synopsis
- The study researched the optimal dose of lurasidone for treating bipolar depression, focusing on efficacy, acceptability, and metabolic/endocrine effects.
- It reviewed five clinical trials involving 2,032 patients and found that doses between 40-60 mg significantly improved depression, anxiety, and quality of life while experiencing manageable side effects.
- Results indicated that while higher doses led to increased side effects and weight gain, a 40-60 mg dose was generally the best choice for treatment without major risks of dropout or manic switch.
Article Synopsis
- - The study evaluated how well an AI chatbot (ChatPDF) could create abstracts from 30 academic psychiatric articles, comparing its output with that of human-written abstracts from 10 additional psychiatric papers.
- - The results showed low similarity and plagiarism rates in the AI-generated abstracts, but the quality varied: structured abstracts performed similarly to originals, while unstructured ones scored lower, and overall, inaccuracies were found in 30% of the AI conclusions.
- - Experts noted that while AI models like ChatPDF have potential for summarizing psychiatric information, caution is needed due to accuracy concerns in the final outputs.
Article Synopsis
- Psilocybin-assisted therapy has been shown to help reduce clinical depressive symptoms, but this study investigates how different types of psychological support influence its effectiveness.
- The research analyzed 10 clinical trials involving 515 patients with depression and categorized psychological support into four types, revealing a significant overall positive effect of psilocybin therapy.
- The findings indicate that while various psychological protocols were used, the type of support provided did not significantly impact the improvement of depressive symptoms in patients undergoing psilocybin therapy.
Objective: To evaluate the comparative effectiveness and acceptability of oral monotherapy using psychedelics and escitalopram in patients with depressive symptoms, considering the potential for overestimated effectiveness due to unsuccessful blinding.
Design: Systematic review and Bayesian network meta-analysis.
Data Sources: Medline, Cochrane Central Register of Controlled Trials, Embase, PsycINFO, ClinicalTrial.
The efficacy and acceptability of anti-inflammatory omega-3 polyunsaturated fatty acid supplements in sepsis management: a network meta-analysis of randomized controlled trials.
Prostaglandins Leukot Essent Fatty Acids
March 2024
Sepsis is a critical medical condition associated with high mortality for patients. Current pharmacological strategies for sepsis management or prevention had not achieved satisfactory results. The omega-3 fatty acids, with anti-inflammatory benefits, are considered to be promising agents for sepsis management/prevention.
View Article and Find Full Text PDFArticle Synopsis
- Audiovestibular dysfunction in systemic lupus erythematosus (SLE) has been overlooked, affecting both hearing and balance systems, with various proposed mechanisms such as immune responses and medication side effects.
- Current tests for evaluating this dysfunction lack specificity and sensitivity, and there is no agreed-upon treatment strategy, though a specific steroid protocol has been suggested in the recent review of literature.
- The systematic review summarized existing research on the causes, examination methods, and potential treatments for audiovestibular issues in SLE, emphasizing the importance of timely recognition and management for possible reversibility of symptoms.
Article Synopsis
- The study conducted a systematic review of randomized controlled trials to evaluate the effectiveness of non-invasive brain stimulation (NIBS) interventions for reducing symptoms of autism spectrum disorder.
- Only one specific intervention—anodal transcranial direct current stimulation (tDCS) combined with cathodal tDCS—showed a significant improvement in autistic symptoms compared to sham controls, with a standardized mean difference of -1.40.
- However, no notable improvements were observed in social-communication symptoms or repetitive behaviors, and all NIBS interventions had comparable dropout rates and no serious adverse events reported.
The depression response trajectory after a course of repetitive transcranial magnetic stimulation(rTMS) remains understudied. We searched for blinded randomized controlled trials(RCTs) that examined conventional rTMS over left dorsolateral prefrontal cortex(DLPFC) for major depressive episodes(MDE). The effect size was calculated as the difference in depression improvement, between active and sham rTMS.
View Article and Find Full Text PDFBackground: Studies have demonstrated that exercise can mitigate the intensity of menstrual pain in primary dysmenorrhea, but the most effective type of exercise remains unclear. The objective of this systematic review and network meta-analysis was to evaluate the effectiveness of different exercise regimens in reducing pain associated with primary dysmenorrhoea.
Methods: Randomized controlled trials investigating the relationship between menstrual pain and exercise were selected from major electronic databases until February 2, 2024.
The prevalence of pediatric constipation ranges from 0.7 to 29.6% across different countries.
View Article and Find Full Text PDFIntroduction: Despite its high lifetime prevalence rate and the elevated disability caused by posttraumatic stress disorder (PTSD), treatments exhibit modest efficacy. In consideration of the abnormal connectivity between the dorsolateral prefrontal cortex (DLPFC) and amygdala in PTSD, several randomized controlled trials (RCTs) addressing the efficacy of different noninvasive brain stimulation (NIBS) modalities for PTSD management have been undertaken. However, previous RCTs have reported inconsistent results.
View Article and Find Full Text PDF: Existing evidence indicates the potential benefits of electroencephalography neurofeedback (NFB) training for cognitive function. This study aims to comprehensively review all available evidence investigating the effectiveness of NFB on working memory (WM) and episodic memory (EM) in the elderly population. : A systematic search was conducted across five databases to identify clinical trials examining the impact of NFB on memory function in healthy elderly individuals or those with mild cognitive impairment (MCI).
View Article and Find Full Text PDFAim: This study aimed to examine dose-effects of total pulses on improvement of depressive symptoms in patients with treatment-resistant depression (TRD) receiving repetitive transcranial magnetic stimulation (rTMS) over the left dorsal lateral prefrontal cortex (DLPFC).
Materials And Methods: The MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, PsycINFO, and ClinicalTrial.gov databases were systematically searched.
Background: ChatGPT may act as a research assistant to help organize the direction of thinking and summarize research findings. However, few studies have examined the quality, similarity (abstracts being similar to the original one), and accuracy of the abstracts generated by ChatGPT when researchers provide full-text basic research papers.
Objective: We aimed to assess the applicability of an artificial intelligence (AI) model in generating abstracts for basic preclinical research.
Article Synopsis
- - Migraine affects 9% to 18% of the global population, and existing preventative medications often show low effectiveness (40%-50% response rates) and have safety concerns.
- - Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are emerging as promising alternatives for migraine prevention, and a meta-analysis evaluated their efficacy compared to other FDA-approved treatments.
- - The analysis of 40 studies revealed that high-dose EPA/DHA significantly reduces migraine frequency and severity, and shows the best acceptability compared to other interventions, suggesting it could be a top choice for prophylactic treatment.
Non-invasive brain stimulation (NIBS) is a promising treatment for bipolar depression. We systematically searched for randomized controlled trials on NIBS for treating bipolar depression (INPLASY No: 202340019). Eighteen articles (N = 617) were eligible for network meta-analysis.
View Article and Find Full Text PDFArticle Synopsis
- Zuranolone is a promising antidepressant that was found to effectively reduce depressive and anxiety symptoms in individuals with major depressive disorder (MDD) based on a systematic review of 7 studies with 1789 patients.
- It improved response and remission rates significantly, though patients experienced more side effects compared to a control group.
- Higher doses (up to 30 mg) correlated with better outcomes for depression and anxiety, but exceeding this dose increased side effects; postpartum-onset MDD patients may benefit more from zuranolone treatment, although the difference was not statistically significant.
Objectives: The aim of this network meta-analysis (NMA) was to assess whether participants assigned to a placebo and standard of care (SoC) group had different major coronavirus disease 2019 (COVID-19)-related outcomes than those assigned to SoC alone.
Design: Frequentist model-based NMA.
Setting: We searched for randomised controlled trials (RCTs) of Janus kinase/Bruton tyrosine kinase inhibitors for the management of COVID-19.