Study of the coordination and solution structures for the interaction systems between diperoxidovanadate complexes and 4-(pyridin-2-yl)pyrimidine-like ligands.

To understand the substitution effects of 4-(pyridin-2-yl)pyrimidine (pprd) on the coordination reaction equilibria, the interactions between a series of the pprd-like ligands and [OV(O(2))(2)(H(2)O)](-) or [OV(O(2))(2)(HOD)](-) or [OV(O(2))(2)(D(2)O)](-) (bpV) have been explored by a combination of multinuclear ((1)H, (13)C, and (51)V) magnetic resonance, heteronuclear single quantum coherence (HSQC) and variable temperature NMR in a 0.15 mol L(-1) NaCl D(2)O solution that mimics physiological conditions. The direct NMR data are reported for the first time.

[Effect of acidity on the interaction of Ofloxacin and bovine serum albumin].

Bovine serum albumin (BSA) exists as N(pH -7.0), B(pH -9.0), and E (pH < 3.

Binding interaction of gatifloxacin with bovine serum albumin.

The binding of gatifloxacin to bovine serum albumin (BSA) in aqueous solution was studied using fluorescence spectroscopy and absorbance spectra, Further, the interactions influenced by Fe3+ and Cu2+ were also explored in this work. Based on Scatchard's site-binding model and florescence quenching, practical formulas for small molecule ligands to bio-macromolecules have been proposed. The binding parameters were measured according to suggested models, and the binding distance and the transfer efficiency of energy between gatifloxacin and BSA were also obtained in view of the Förster theory of non-radiation energy transfer.