Cardiopulmonary Exercise Testing-Guided Exercise Therapy in Hypertensive Patients: A Single Center Study.

To observe the effects of cardiac rehabilitation guided by cardiopulmonary exercise testing (CPET) on cardiorespiratory reserve function, blood pressure, blood pressure variability, and lipid metabolism in patients with hypertension. A randomized trial enrolled 67 Grade 1 hypertensive patients on antihypertensive drugs, divided into conventional ( = 35) and CPET ( = 32) groups. Antihypertensive drugs were not adjusted in both groups during the study period.

Thioredoxin-interacting protein (TXNIP) inhibition promotes retinal ganglion cell survival and facilitates M1-like microglial transformation via the PI3K/Akt pathway in glaucoma.

Background: Glaucoma is a group of heterogeneous neurodegenerative diseases with abnormal energy metabolism and imbalanced neuroinflammation in the retina. Thioredoxin-interacting protein (TXNIP) is involved in glucose and lipid metabolism, and associated with oxidative stress and inflammation, however, not known whether to be involved in glaucoma neuropathy and its underlying mechanisms.

Methods: To establish the chronic ocular hypertension (COH) mice model.

GLP-1 RECEPTOR AGONISTS USE AND INCIDENCE OF GLAUCOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS: GLP-1 receptor agonists use and incidence of glaucoma.

Introduction: In diabetics, glucagon-like peptide 1 (GLP-1) receptor agonists (RA) may protect against microvascular alterations and oxidative stress, both of which have been implicated in glaucoma. Multiple studies suggest a possible relation between GLP-1 RA use and the development of glaucoma. This study performs a systematic review of the literature regarding the incidence of glaucoma development in type 2 diabetes patients treated with GLP-1 receptor agonists compared to a control group.

Neratinib enhances the efficacy of CDK4/6 inhibitor plus endocrine therapy in HR/HER2-low breast cancer cell line ZR-75-1 via hsa-miR-23a-5p.

HR/HER2-low breast cancer is a significant subgroup of conventional HR/HER2-negative breast cancer, and combination of CDK4/6 inhibitor and endocrine therapy is the standard first-line and second-line treatments for advanced HR/HER2-low breast cancer. Nevertheless, it remains uncertain whether HER2 signaling affects the effectiveness of CDK4/6 inhibitor administered in combination with endocrine therapy for HR/HER2-low breast cancer and suitable intervention measures. This study revealed poor efficacy for CDK4/6 inhibitor combined with endocrine therapy for HR/HER2-low breast cancer in vitro and in vivo models.

Engineering n-Type and p-Type BiOI Nanosheets: Influence of Mannitol on Semiconductor Behavior and Photocatalytic Activity.

Photocatalytic technology holds significant promise for sustainable development and environmental protection due to its ability to utilize renewable energy sources and degrade pollutants efficiently. In this study, BiOI nanosheets (NSs) were synthesized using a simple water bath method with varying amounts of mannitol and reaction temperatures to investigate their structural, morphological, photoelectronic, and photocatalytic properties. Notably, the introduction of mannitol played a critical role in inducing a transition in BiOI from an n-type to a p-type semiconductor, as evidenced by Mott-Schottky (M-S) and band structure analyses.

Dual-functional CuO/g-CN heterojunctions: a high-performance SERS sensor and photocatalytic self-cleaning system for water pollution detection and remediation.

This study introduces a multifunctional device based on CuO/g-CN monitoring and purification p-n heterojunctions (MPHs), seamlessly integrating surface-enhanced Raman scattering (SERS) detection with photocatalytic degradation capabilities. The SERS and photocatalytic performances of the CuO in various morphologies, g-CN nanosheets (NSs) and CuO/g-CN MPHs with different g-CN mass ratios were systematically evaluated, with a particular emphasis on the CuO/g-CN-0.2 MPH, where g-CN constituted 20% of the total mass.

Association between early-stage diabetic nephropathy and the delayed monophasic glucose peak during oral glucose tolerance test in type 2 diabetes mellitus.

Aims: To explore the relationships between the delayed monophasic glucose peak during oral glucose tolerance test (OGTT) and early-stage diabetic nephropathy (DN) in patients with type 2 diabetes mellitus(T2DM), and to speculate its potential as a risk factor for early-stage DN.

Materials And Methods: This retrospective observational study included 448 participants, all of whom underwent a 3-h OGTT. Based on peak glucose time, they were categorized into the normal glucose tolerance (NGT) group (n = 76), the early delayed group (n = 98), and the late delayed group (n = 274) for comparison.

Therapeutic approaches targeting oncogenic proteins in myeloid leukemia: challenges and perspectives.

Introduction: Leukemia is typically categorized into myeloid leukemia and lymphoblastic leukemia based on the origins of leukemic cells. Myeloid leukemia is a group of clonal malignancies characterized by the presence of increased immature myeloid cells in both the bone marrow and peripheral blood. Of note, the aberrant expression of specific proteins or the generation of fusion proteins due to chromosomal abnormalities are well established drivers in various forms of myeloid leukemia.

Effect of exercise on physical fitness and quality of life in patients with pulmonary embolism: a systematic review and meta-analysis.

Background: Pulmonary embolism (PE) survivors frequently experience persistent dyspnea and diminished quality of life (QoL). Evidence suggests that rehabilitation exercise has a positive impact on QoL, physical fitness, and dyspnea in patients with heart disease and chronic obstructive pulmonary disease. However, the effects of exercise on patients with PE remain ambiguous.

Integrative multi-omics reveals the mechanism of ulcerative colitis treated with Ma-Mu-Ran antidiarrheal capsules.

Rationale: Ulcerative colitis (UC) is a chronic inflammatory gastrointestinal disease typically coexisting with intestinal microbiota dysbiosis, oxidative stress, and an inflammatory response. Although its underlying mechanism of action is unclear, Ma-Mu-Ran Antidiarrheal Capsules (MMRAC) have demonstrated significant therapeutic efficacy for UC.

Methods: The mechanism of action of MMRAC in the treatment of UC model was investigated by combining metabolomics, transcriptomics, and intestinal microbiota detection techniques.

Compositional engineering of phase-stable and highly efficient deep-red emitting phosphor for advanced plant lighting systems.

Inorganic luminescent materials hold great promise for optoelectronic device applications, yet the limited efficiency and poor thermal stability of oxide-based deep-red emitting phosphors hinder the advancement of plant lighting technologies. Herein, a simple compositional engineering strategy is proposed to stabilize the phase, boost external quantum efficiency (EQE) and enhance thermal stability. The chemical modification of the PO tetrahedron in NaMgPO:Eu by incorporating SiO lowers the formation energy, leading to the generation of pure olivine phase and increasing the EQE from 27% to 52%, setting a record for oxide deep-red phosphors.

Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease.

The connection between the gut mycobiome and atherosclerotic cardiovascular disease (ACVD) is largely uncharted. In our study, we compared the gut fungal communities of 214 ACVD patients with those of 171 healthy controls using shotgun metagenomic sequencing and examined their interactions with gut bacterial communities and network key taxa. The gut mycobiome composition in ACVD patients is significantly different, showing a rise in opportunistic pathogens like , , and , with and showing the most significant changes (Wilcoxon rank-sum test, < 0.

A study on the intervention effect of a case management model that breaks through spatiotemporal characteristics in home-based phase II exercise rehabilitation post PCI.

Objective: This study aims to explore the effect of a case management model that breaks through the temporal and spatial characteristics on the at-home phase II exercise rehabilitation of postoperative patients treated with percutaneous coronary intervention (PCI).

Methods: We used the convenience sampling method to select 103 patients with coronary artery disease (53 in the observation group and 50 in the control group) who were admitted to the Department of Cardiovascular Internal Medicine at the Jiaxing No. 2 Hospital in January 2022 and January 2023 and underwent PCI treatment as study subjects.

Application of Protease-Hydrogen Peroxide Digestion Method in Forensic Diatom Examination.

Objectives: To propose a novel forensic diatom examination method, namely the protease-hydrogen peroxide (PHP) digestion method, and to explore its potential application in forensic practice.

Methods: The PHP digestion method was applied to process lung tissues and compared with the traditional nitric acid digestion method in terms of diatom quantity, recovery rate, proportion of diatom fragments, and recovery efficiency of different diatom genera.

Results: The PHP digestion method showed higher diatom quantity, recovery rate, and proportion of diatom fragments compared to the traditional nitric acid digestion method with statistical significance.

Unraveling Spatiotemporal Metabolic Perturbation of Amino Acids Associated with Ischemia-Reperfusion Injury by MALDI MS Imaging.

Various complex metabolic perturbations are involved in cerebral ischemia-reperfusion (I/R) injury. However, limited data have been reported on dynamic spatiotemporal metabolic perturbations of amino acids (AAs) in I/R injured rat brains. In this work, a combination of laser-assisted chemical transfer (LACT) and hexafluoroisopropanol (HFIP) was applied to the enhancement of on-tissue derivatization of AAs for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) of their dynamic spatiotemporal changes during I/R injury.

Flooding increases plant-derived carbon accumulation in soils of aquatic-terrestrial ecotone.

Soils in the aquatic-terrestrial zone undergo periodic flooding and act as significant carbon sinks. However, the mechanisms governing soil organic carbon (SOC) formation in these zones are not well understood. This study elucidates the effects of periodic flooding on SOC accumulation at the water level drawdown zone of the Three Gorges Reservoir, using lignin phenols and amino sugars as indicators of plant- and microbial-derived carbon.

Photocatalytic Enhancement and Recyclability in Visible-Light-Responsive 2D/2D g-CN/BiOI p-n Heterojunctions via a Z-Scheme Charge Transfer Mechanism.

With the intensification of the energy crisis and the growing concern over environmental pollution, particularly the discharge of organic dye pollutants in industrial wastewater, photocatalytic degradation of these contaminants using solar energy has emerged as an effective, eco-friendly solution. In this study, we successfully synthesized 2D/2D g-CN/BiOI p-n heterojunctions via a simple precipitation method and a high-temperature calcination method. The unique 2D structures of g-CN nanosheets (NSs) and BiOI NSs, coupled with the synergistic effect between the two materials, significantly enhanced the photocatalytic degradation performance of the heterojunctions under simulated sunlight.

Dimensions of Job Demands Among New-Generation Employees Based on Online Reviews by Employees.

Based on employees' online reviews, this article analyzes the dimensions of job demand for new-generation employees, using a combination model of Latent Dirichlet Allocation, decision-making trials and evaluation laboratory, interpretative structural modeling, and cross-impact matrix multiplication (LDA-DEMATEL-ISM-MICMAC). The results show that job demand is composed of 10 dimensions, and there is significant interdependence between the dimensions. Changing one dimension will quickly affect the other dimensions.

Hepatic arterial infusion chemotherapy (HAIC) combined with Tislelizumab and Lenvatinib for unresectable hepatocellular carcinoma: a retrospective single-arm study.

Purpose: We aimed to explore the curative effects of hepatic arterial infusion chemotherapy (HAIC) combined with Tislelizumab and Lenvatinib on unresectable hepatocellular carcinoma (HCC).

Patients And Methods: From September 2021 to September 2023, 42 patients with unresectable HCC who were treated in the First Affiliated Hospital of Chongqing Medical University were enrolled in this retrospective single-arm study. They received HAIC combined with Tislelizumab and lenvatinib.

Zebrafish patient-derived xenograft system for predicting carboplatin resistance and metastasis of ovarian cancer.

Aims: Ovarian cancer (OC) remains a significant challenge in oncology due to high rates of drug resistance and disease relapse following standard treatment with surgery and platinum-based chemotherapy. Despite the widespread use of these treatments, no effective biomarkers currently exist to identify which patients will respond favorably to therapy. This study introduces a zebrafish patient-derived xenograft (PDX) system, capable of replicating both the carboplatin response and metastatic behavior observed in OC patients, within a rapid 3-day assay period.