Comparative transcriptomes and WGCNA reveal hub genes for spike germination in different quinoa lines.

Background: Quinoa, as a new food crop, has attracted extensive attention at home and abroad. However, the natural disaster of spike germination seriously threatens the quality and yield of quinoa. Currently, there are limited reports on the molecular mechanisms associated with spike germination in quinoa.

Patterns of recurrence after esophagectomy following neoadjuvant immunochemotherapy in patients with thoracic esophageal squamous cell carcinoma.

Purpose: To explore the recurrence pattern and risk factors associated with the relapse of thoracic esophageal squamous cell carcinoma (TESCC) among patients who received esophagectomy following neoadjuvant immunochemotherapy (NICT).

Methods: A total of 191 TESCC patients who received esophagectomy following NICT were retrospectively reviewed from 2019 to 2022. The first recurrence patterns were assessed.

C-Type Lectin S Group TcCTL4 Participates in the Immunity of Tribolium castaneum.

C-type lectin S (CTL-S) plays a crucial role in pathogen recognition and the activation of immune response. In comparison, the proportion of CTL-S was relatively high in insects, but the study was much smaller than the proportion observed. In this study, we cloned and characterized one CTL-S, TcCTL4, from Tribolium castaneum.

How do green municipal bonds affect carbon emissions in China? Evidence from the staggered difference-in-differences approach.

Under the "Dual Carbon Goals", China's municipal government bonds play a vital role in advancing local environmental governance. This paper constructs a quasi-natural experiment based on the issuance of green municipal bonds, and empirically examines its carbon emission reduction effects by using the staggered difference in differences approach. The issuance of green municipal bonds can substantially diminish the level of carbon intensity and pass a series of robustness tests.

Nanoconfined catalytic macrostructures for advanced water remediation: From basic understanding to future application strategies.

In recent years, nanoconfined catalytic macrostructures applied to advanced oxidation processes (AOPs) have been rapidly developed, effectively solving the problems of traditional heterogeneous AOPs, such as mass transfer limitation, limited diffusion of short-lived reactive oxygen species (ROS), and aggregation/leaching of catalysts. Compared with the traditional heterogeneous AOPs systems, the nanoconfined catalytic macrostructures have unique interactions between the oxidants, catalysts, ROS and micropollutants, which could significantly increase the yield and mass transfer of ROS. At present, there is a lack of comprehensive reviews on the nanoconfined catalytic macrostructures from basic theory to application performances and future development strategies.

Comparative Efficacy of Unilateral Biportal Endoscopy vs Traditional Surgery in Lumbar Degenerative Disorders.

BACKGROUND Lumbar degenerative diseases, such as lumbar disc herniation, cause significant pain and neurological deficits. Traditional surgeries like posteriior lumbar interbody fusion (PLIF) have drawbacks, including extensive tissue damage. We sought to evaluate the efficacy of unilateral biportal endoscopy (UBE) compared with PLIF, with a focus on clinical outcomes and complication rates.

TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis.

Objective: The trigger receptor expressed on myeloid cells-2 (TREM2) pathway in myeloid cells is a key disease-inducing immune signaling hub that is essential for detecting tissue damage and limiting its pathological spread. However, the role and potential mechanisms of TREM2 in wound repair remain unclear. The purpose of this study was to determine the role and mechanism of TREM2 in skin wound healing in mice.

Bioinspired balloon catheter integrated with stretchable "flounder" electrodes under high voltage for uniform pulsed field ablation.

Atrial fibrillation leads to severe diseases such as heart failure and strokes. While catheter ablation is prevalent for the treatment, existing techniques hardly can achieve both tissue selectivity and ablation uniformity. Here, we propose a bioinspired strategy for balloon-based pulsed field ablation (PFA) systems based on "flounder" electrodes.

Clinicopathological characteristics of light chain proximal tubulopathy: a multicentre case series.

Aims: Light chain proximal tubulopathy (LCPT) is a rare complication of paraprotein-related diseases. We report a case series to present the clinicopathological characteristics and outcomes of LCPT.

Methods: A multicentre retrospective case series of 47 patients with LCPT, consisting of 36 crystalline, three non-crystalline, and eight mixed LCPTs, was studied between January 2007 and December 2023.

RANK IVVY motif plays crucial roles in osteoclastogenesis.

RANKL and its receptor RANK play a vital role in osteoclastogenesis. RANK primarily recruits TRAFs to promote osteoclastogenesis but also contains an TRAF-independent motif (IVVY), which mediates osteoclast lineage commitment in vitro. Here, we have developed knockin mice in which inactivating mutations are introduced in the IVVY motif (IVVY to IVAF).

Association Between Sleep Reactivity, Pre-Sleep Arousal State, and Neuroendocrine Hormones in Patients with Chronic Insomnia Disorder.

Purpose: The purpose of this study was to look into the relationship between pre-sleep arousal state, sleep reactivity, and serum levels of neuroendocrine hormones (cortisol, copeptin, and corticotropin-releasing hormone) in patients with chronic insomnia disorders (CID), and whether the effects of sleep reactivity and pre-sleep arousal on insomnia are related to the levels of these neuroendocrine hormones.

Patients And Methods: This study included 61 CID patients and 27 healthy controls (HC) whose base data were matched to those of the CID patients. The Pittsburgh Sleep Quality Index(PSQI), Pre-Sleep Arousal Scale (PSAS), and the Ford Insomnia Response to Stress Test (FIRST) were used to evaluate the participants' sleep, stress, and neuropsychological function.

Evaluation of intranasal TLR2/6 agonist INNA-051: safety, tolerability and proof of pharmacology.

Background: Local priming of the innate immune system with a Toll-like receptor (TLR)2/6 agonist may reduce morbidity and mortality associated with viral respiratory tract infections, particularly for the elderly and those with chronic diseases. The objectives of the present study were to understand the potential of prophylactic treatment with a TLR2/6 agonist as an enhancer of innate immunity pathways leading to accelerated respiratory virus clearance from the upper airways.

Methods: Two randomised, double-blind, placebo-controlled clinical trials were conducted in healthy adult participants.

Adipose-Derived Stem Cells Prevent Anastomotic Leak: A Porcine Ischemic Esophagectomy Model.

Introduction: Esophagectomy is a lifesaving procedure plagued by an anastomotic leak rate of 11%-35%. Ischemia is widely accepted to be the most significant risk factor for anastomotic leak. We hypothesized that the injection of adipose-derived stem cells (ASCs) into an ischemic esophagogastric anastomosis would prevent leakage.

Quantitative evaluation of microenvironmental changes and efficacy of cupping therapy under different pressures based on photoacoustic imaging.

Cupping therapy, a traditional Chinese medicinal practice, has been subjected to scientific scrutiny to validate its effects on local tissue microenvironments. This study provides a quantitative assessment of cupping therapy at different negative pressures using photoacoustic imaging. Low-pressure cupping (-20 kPa) significantly improved local blood circulation, evidenced by increased hemoglobin oxygen saturation and vessel dilation that normalized within two hours.

A latent class analysis of co-occurring insomnia and anxiety among Chinese pregnant women.

Currently, there remains a paucity of comprehensive evidence concerning the concurrent presence of insomnia and anxiety in pregnant women. This study, employing convenience sampling, enrolled 1049 Chinese pregnant women. Key assessment instruments comprised a three-item Insomnia Symptoms scale, a two-item Generalized Anxiety Disorder Scale, as well as measures of demographic and pregnancy-specific characteristics.

Suppression of cGAS/STING pathway-triggered necroptosis in the hippocampus relates HS to attenuate cognitive dysfunction of Parkinson's disease.

Background: Cognitive dysfunction is the most severe non-motor symptom of Parkinson's disease (PD). Our previous study revealed that hydrogen sulfide (HS) ameliorates cognitive dysfunction in PD, but the underlying mechanisms remain unclear. Hippocampal necroptosis plays a vital role in cognitive dysfunction, while the cGAS/STING pathway triggers necroptosis.

Decreased serum SLC7A11 and GPX4 levels may reflect disease severity of acute ischaemic stroke.

Objective: This study aimed to examine the levels of solute carrier family seven number 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) in the serum of patients with acute ischaemic stroke (AIS) and their relationship with disease severity.

Methods: A total of 148 patients with AIS together with 148 healthy controls (HCs) were enrolled. The expression levels of SLC7A11 and GPX4 in serum were detected immediately as early as possible.

HTAD: a human-in-the-loop framework for supervised chromatin domain detection.

Topologically associating domains (TADs) are essential units of genome architecture, influencing transcriptional regulation and diseases. Despite numerous methods proposed for TAD identification, it remains challenging due to complex background and nested TAD structures. We introduce HTAD, a human-in-the-loop TAD caller that combines machine learning with human supervision to achieve high accuracy.

Tumor differentiation-dependent conditional survival of patients with operable thyroid cancer.

Objective: Little is known about the changing risk profile of death and conditional survival in patients with operable thyroid cancer. This study aimed to investigate the annual hazard rate of cancer death, actuarial disease-specific survival (DSS), and conditional DSS in patients with thyroid cancer and explore the effects of tumor differentiation.

Methods: Patients diagnosed with thyroid cancer (N = 132,354) between 2004 and 2019 were identified from the Surveillance, Epidemiology, and End Results database.