Protective effect of appendectomy against the onset of ulcerative colitis: A case-control study.

Background: Previous studies suggest that appendectomy has a protective effect against ulcerative colitis (UC); however, relatively few studies focusing on this topic have been reported in China.

Aim: To explore the correlation between appendectomy and the onset of UC.

Methods: A total of 313 patients with newly diagnosed UC and 313 healthy individuals were selected for this study.

Increased spindle-related brain activation in right middle temporal gyrus during N2 than N3 among healthy sleepers: Initial discovery and independent sample replication.

The association between spindle metrics and sleep architecture differs during N2 vs. N3 sleep, the underlying neural mechanism is not clearly illustrated. Here, we tested the discrepancy in spindle-related brain activation between N2 and N3 within healthy college students (dataset 1: n = 27, 59 % females, median age 23 years), using simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI).

Negative pressure assisted rubbing suction technique for the treatment of axillary osmidrosis based on minimally invasive principle.

Background: Axillary Osmidrosis is highly prevalent and occurr in adolescents, bilateral onset, its pathogenesis is related to abnormal secretion function of apocrine glands, with a significant genetic predisposition, the patient's bilateral armpit area can smell a spicy pungent odor, although it does not affect the health, but it is inconvenient to life, socialize. Patients are often accompanied by low self-esteem and urgently require treatment, and most of them have the requirement of minimally invasive treatment and minimal scarring.

Method: In this study, we aimed to evaluate the efficacy of minimally invasive treatment of axillary osmidrosis with refined negative pressure-assisted rubbing suction technique.

Refining the Rab7-V1G1 axis to mitigate iron deposition: Protective effects of quercetin in alcoholic liver disease.

Iron overload is a common feature of alcoholic liver disease (ALD) and contributes significantly to disease progression. Quercetin, a flavonoid known for its iron-chelating properties, has emerged as a potential protective compound against ALD. However, research on quercetin's regulatory effects on iron levels in ALD is limited.

Associations between adherence to 24-Hour Movement Guidelines with continuous metabolic syndrome score among Chinese children and adolescents.

Objectives: The objective of this study was to evaluate the associations between adherence to 24-Hour Movement Guidelines (24-HMG) with continuous metabolic syndrome score (cMetS) among Chinese children.

Study Design: Cross-sectional study.

Methods: We conducted a cross-sectional study among 4604 children aged 6-17 years from Shenzhen, China.

Knowledge, attitudes, and practices (KAP) regarding intra-abdominal pressure monitoring among pediatric intensive care nurses: A cross-sectional study.

Objectives: This study aimed to assess the knowledge, attitudes, and practices (KAP) and the training requirements of pediatric intensive care nurses regarding intra-abdominal pressure (IAP) monitoring, in order to provide a reference for the development of relevant training programs and operational procedures in clinical practice.

Methods: This descriptive cross-sectional survey was conducted from April 2023 to June 2023. A convenience sample was created by recruiting 212 pediatric intensive care nurses in eight hospitals in Zhejiang Province.

Spatial distribution of residential environment, genetic susceptibility, and psoriasis: A prospective cohort study.

Background: Genetic and environmental factors contribute to psoriasis, but the impact of residential environments on this condition remains uncertain. We aimed to investigate the association of residential environments with psoriasis risk and explore its interaction with genes.

Methods: We retrieved data on the spatial distribution of residential environments at 300 and 1000 m buffer zones from the UK Biobank, including the proportions of natural environments, domestic gardens, green spaces, and blue spaces within these zones.

A multi-scale feature selection module based architecture for the diagnosis of Alzheimer's disease on [F]FDG PET.

Objective: Alzheimer's disease (AD) is a prevalent form of dementia worldwide as a cryptic neurodegenerative disease. The symptoms of AD will last for several years, which brings great mental and economic burden to patients and their families. Unfortunately, the complete cure of AD still faces great challenges.

Study on Optimization Strategy for the Composition Transition Gradient in SS 316L/Inconel 625 Functionally Graded Materials.

Wire arc additive manufacturing (WAAM) technology enables the fabrication of functionally graded materials (FGMs) by adjusting the wire feed speed of different welding wires in a layer-by-layer manner. This study aimed to produce SS 316L/Inconel 625 FGMs with varying transition compositions using dual-wire arc additive manufacturing (D-WAAM). An optimization strategy for transition gradients was implemented to exclude component regions that are prone to defect formation (notably cracking), as well as to retain other component regions, thereby enhancing the overall mechanical properties of FGMs.

The Inverted U-Shaped Association between Serum Vitamin D and Serum Uric Acid Status in Children and Adolescents: A Large Cross-Sectional and Longitudinal Analysis.

Background: Serum vitamin D is associated with hyperuricemia. However, previous studies have been controversial, with limited focus on children and adolescents.

Objective: This study aimed to examine the cross-sectional and longitudinal associations between serum vitamin D and serum uric acid (SUA) levels in children and adolescents.

Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis.

Atherosclerosis (AS) with iron and lipid overload and systemic inflammation is a risk factor for Alzheimer's disease. M1 macrophage/microglia participate in neuronal pyroptosis and recently have been reported to be the ferroptosis-resistant phenotype. Quercetin plays a prominent role in preventing and treating neuroinflammation, but the protective mechanism against neurodegeneration caused by iron deposition is poorly understood.

Assessment of the combined vulnerability to droughts and heatwaves in Shandong Province in summer from 2000 to 2018.

Droughts and heat waves exhibit synergistic effects and are among the world's most costly disasters. To explore the spatiotemporal differences and formation mechanisms of the combined vulnerability to droughts and heat waves in Shandong Province over the past 20 years, a vulnerability scoping diagram (VSD) model with three dimensions-exposure, sensitivity, and adaptability-was constructed to assess and compare the combined vulnerability to high-temperature and drought events, considering economic and social conditions. The results showed that (1) over the past 20 years, heat waves and droughts have increased in Shandong Province.

Preparation of FeO@CA/BNNS/AgNP Magnetic Microspheres and Photocatalysis of Dyes.

In this work, sea urchin-like magnetic FeO@CA/BNNS/AgNP composite microspheres were successfully prepared. The photocatalytic performance of composite microspheres for the organic dye rhodamine B (RhB) was systematically investigated under different conditions, and the catalytic degradation rate of RhB was as high as 95% within 60 min; after three cycles of recycling, the degradation rate of RhB was reduced by only 8%. The main active agents in the reaction are e and O.

Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin.

Scope: Iron deposition is frequently observed in alcoholic liver disease (ALD), which indicates a potential role of ferroptosis in its development. This study aims to explore the effects of quercetin on ferroptosis in ALD and elucidates the underlying mechanism involving the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs) mediated by protein kinase RNA-like endoplasmic reticulum kinase (PERK).

Methods And Results: C57BL/6J mice are fed either a regular or an ethanol-containing liquid diet (with 28% energy form ethanol) with or without quercetin supplementation (100 mg kg BW) for 12 weeks.

Excess iron accumulation mediated senescence in diabetic kidney injury.

Cellular senescence and iron accumulation were separately observed in diabetic nephropathy (DN). Limited evidence supports that iron was significantly accumulated in senescent cells. We aimed to explore whether iron is involved in the pathogenesis role of senescence in DN.

Chinese Healthy Eating Index (CHEI) and risk of diabetes in Chinese adults: a prospective cohort study.

Purpose: The Chinese Healthy Eating Index (CHEI) is a valid instrument to assess the diet quality of the Chinese population, but evidence regarding the relationship between CHEI and the risk of diabetes remains limited. We aimed to investigate the prospective association of CHEI with diabetes among Chinese adults.

Methods: 1563 adults free of diabetes at baseline and with at least two survey data from 1997 to 2018 were included.

Lung adenocarcinoma with brain metastasis detected dual fusion of LOC399815-ALK and ALK-EML4 in combined treatment of Alectinib and CyberKnife: A case report.

Introduction: The anaplastic lymphoma kinase (ALK) gene fusion occurs in approximately 3% to 7% of nonsmall cell lung cancer (NSCLC), in which occurs approximately 23% to 31% of brain metastasis patients in poor prognosis. ALK tyrosine kinase inhibitors have shown efficacy in treating ALK-positive (ALK+) NSCLC. More than 90 distinct subtypes of ALK fusions have been identified through sequencing technique and would lead to significant differences in clinical efficacy, it is necessary to guide clinical treatment effectively by gene detection.

Association of serum 25-hydroxyvitamin D with bone health measured by calcaneal quantitative ultrasound: a large cross-sectional analysis in children and adolescents.

: Vitamin D plays a crucial role in bone health; however, findings in children and adolescents remain inconsistent, and few studies have examined its impact on bone health measured by quantitative ultrasound (QUS). This study aims at assessing the relationship between serum vitamin D levels and bone health, as evaluated by QUS, across varying pubertal stages and genders. : A baseline cross-sectional survey of an ongoing cohort study included 4682 children and adolescents aged 6 to 18 years from Shenzhen, China.

Association between sugar-free beverage intake and childhood obesity among Chinese children and adolescents.

Background: The relationship between sugar-free beverage (SFB) intake and childhood obesity among Chinese children is unknown.

Objectives: To describe the status of SFB consumption among children and adolescents in China and assess the association between SFB intake and different types of obesity.

Methods: The study was based on the baseline data of an ongoing cohort project named Evaluation and Monitoring on School-based Nutrition and Growth in Shenzhen (EMSNGS).