Effects of Combination of 1,25(OH) D and TLR-4 Inhibitor on the Damage to HaCaT Cells Caused by UVB Irradiation.

Objective: Vitamin D and Toll-like receptor-4 (TLR-4) inhibition are involved in the protection of keratinocytes. The effects of combination of 1,25(OH) D and TLR-4 inhibitor on the protection of keratinocytes against ultraviolet radiation B (UVB) irradiation remain unclear. This study was undertaken to explore the effects of combination of 1,25(OH) D and TAK-242 (TLR-4 inhibitor) on the damage to HaCaT cells caused by UVB irradiation.

Evaluation of changes in cardiac output from the electrical impedance waveform in the forearm.

We tested the validity of regional impedance cardiography (RIC) for measuring changes in both cardiac output and stroke volume by comparing the values with a 2D ultrasound technique in response to the breath-hold manipulation. Among 13 subjects, changes in the maximum amplitude of the regional impedance waveform from the forearm conformed to those in stroke volume (r = 0.86, p < 0.