Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.

Chemical modification of RNAs is important for posttranscriptional gene regulation. The METTL3-METTL14 complex generates most -methyladenosine (mA) modifications in messenger RNAs (mRNAs), and dysregulated methyltransferase expression has been linked to cancers. Here we show that a changed sequence context for mA can promote oncogenesis.

Trends and prevalence of eating disorders in children and adolescents.

Background: Eating disorders (EDs) have increasingly become a public health problem globally, especially among children and adolescents.

Aim: To estimate the burden of EDs in children and adolescents (ages 5-19 years) at the global, regional, and national levels.

Methods: Retrieved from Global Burden of Disease Study 2019 for EDs, including anorexia nervosa and bulimia nervosa, we extracted the disability-adjusted life years (DALYs) and prevalence rates with 95% uncertainty intervals between 1990-2019.

Transplantation of Islet Organoids into Brown Adipose Tissue in a Diabetic Mouse Model.

Pancreatic islet transplantation is a promising cell replacement therapy for patients with type 1 diabetes (T1D), an autoimmune disease that destroys insulin-producing islet β cells. However, the shortage of donor pancreatic islets significantly limits the widespread use of this strategy as a routine therapy. Pluripotent stem cell-derived insulin-producing islet organoids present a promising alternative β cell source for T1D patients.

[Protective effect of Anmeidan on hippocampal neuronal damage and synaptic microenvironment in sleep-deprived rats based on NRG1/ErbB4 signaling pathway].

This study aims to investigate the effect of Anmeidan on hippocampal neurons and synaptic microenvironments in sleep-deprived rats. Sixty SD rats were randomly divided into blank, model, Anmeidan, and melatonin groups, with 15 rats in one group. The study used the multi-platform method to prepare the sleep deprivation model.

Biomimetic flame retardant adhesive via combining polysiloxane, chitosan and vermiculite nanosheets inspired by nacre and arthropod cuticle.

The wood industry's dependence on traditional petrochemical adhesives, which pose environmental and health risks, has spurred research into sustainable alternatives. Sustainable bio-based polysaccharide materials show promise due to their inherent adhesive properties, despite challenges related to mechanical weaknesses and water resistance. Inspired by the hardening mechanisms of nacre and arthropod cuticles, we have developed a novel biomimetic flame-retardant HPA/OCTS/VMT NSs-NH adhesive.

Hepcidin inhibits hepatocyte apoptosis through the PERK pathway in acute liver injury and fibrosis.

Background: Hepcidin, a peptide hormone primarily produced by the liver, regulates iron metabolism by interacting with its receptor, ferroportin. Studies have demonstrated that hepcidin participates in the progression of liver fibrosis by regulating HSC activation, but its regulatory effect on hepatocytes remains largely unknown.

Methods: A carbon tetrachloride (CCl4)-induced liver fibrosis model was established in C57BL/6 wild-type (WT) and hepcidin knockout (Hamp-/-) mice.

Unraveling the fear of COVID-19 reinfection: insights from frontline doctors in China.

Considering the end of global emergency status of Coronavirus-19 (COVID-19) and the persistent risk of reinfection for healthcare workers (HCWs), it is important to evaluate the attitude of the HCWs toward reinfecting with COVID-19. To gather information about participants' concerns regarding reinfection with COVID-19, a comprehensive online questionnaire was administered to all individuals involved in the study. DASS-21 was used to assess their mental health.

Case report: A novel nonsense mutation in the gene causes nonsyndromic hearing loss in a China family.

The gene is located on chromosome 5q13.2 and is associated with autosomal recessive nonsyndromic hearing loss (OMIM: # 610572). In this study, we identified and reported a novel nonsense mutation in c.

Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.

Clinicians often consider the use of dietary supplements to assist in lowering thyroid autoantibody titres in patients with Hashimoto's thyroiditis (HT). Currently, different supplements differ in their ability to reduce autoantibody levels. The purpose of this article is to compare the ability of different supplements to lower autoantibody titres and restore TSH levels through a systematic literature review.

Targeting extracellular matrix stiffness for cancer therapy.

The physical characteristics of the tumor microenvironment (TME) include solid stress, interstitial fluid pressure, tissue stiffness and microarchitecture. Among them, abnormal changes in tissue stiffness hinder drug delivery, inhibit infiltration of immune killer cells to the tumor site, and contribute to tumor resistance to immunotherapy. Therefore, targeting tissue stiffness to increase the infiltration of drugs and immune cells can offer a powerful support and opportunities to improve the immunotherapy efficacy in solid tumors.

The radiohumeral synovial plica: anatomy, histology, and implications in chronic lateral epicondylitis.

Objectives: Our study aimed to elucidate synovial plica (SP) of the elbow histological characteristics and the anatomical relationship with adjacent structures. Subsequently, we sought to assess the relationship between SP and clinical symptoms as well as magnetic resonance imaging (MRI) features in patients with chronic lateral epicondylitis.

Methods: MRI was performed on eight cadaveric elbows specimens.

Granulocyte Colony Stimulating Factor Enhances Decidualization Process of Endometrial Stromal Cells Through STAT3/HOXA10 Axis.

Background: Recurrent implantation failure (RIF) is characterized by the repeated failure of implantation, often linked to impaired endometrial receptivity. This study investigates how granulocyte colony-stimulating factor (G-CSF) promotes endometrial stromal cell decidualization.

Methods: THESCs (human telomerase reverse transcriptase-immortalized endometrial stromal cells) were used as an in vitro cell model to induce decidualization.

Cationic Coordination Modification Drives Birefringence and Nonlinear Effect Double Lifting in Sulfate.

As nonlinear optical (NLO) crystals, sulfates have the superiority of transparency for ultraviolet (UV) light, but they are often troubled by small nonlinear coefficients and birefringence owing to the high symmetry of the [SO] group. By introducing two neutral diethylenetriamine (DETA) molecules to replace the six coordinated water molecules of the [Zn(HO)] complex cation in [Zn(HO)](SO)(HO), a new sulfate with an acentric structure, namely, [Zn(DETA)](SO)(HO), has been designed and synthesized. Structural investigation reveals that the coordination modification of Zn ion tremendously enhances its intraoctahedral distortion.

Differences Between Patients with Probable UIP and Definite UIP on HRCT in Idiopathic Pulmonary Fibrosis: A Real-World Cohort Study.

Both a probable usual interstitial pneumonia (UIP) pattern (p-UIP) and a definite UIP pattern (d-UIP) on high-resolution computed tomography (HRCT) are sufficient to establish a diagnosis of idiopathic pulmonary fibrosis (IPF) without the need for a surgical lung biopsy, according to the 2022 IPF guidelines. However, it remains unknown whether patients with p-UIP and d-UIP have similar disease behaviors and clinical courses. We retrospectively collected clinical data of patients with IPF and divided the patients into two groups according to their HRCT patterns: a p-UIP group and a d-UIP group.

Use of Transcriptomics to Identify Candidate Genes for Hematopoietic Differences Between Wujin and Duroc Pigs.

Hematopoiesis is a complex physiological process that ensures renewal of blood cells to maintain normal blood circulation and immune function. Wujin pigs exhibit distinct characteristics such as tender meat, high fat storage, strong resistance to roughage, robust disease resistance, and oxidation resistance. Therefore, using Wujin pigs as models may offer valuable insights for hematopoietic-related studies.

Comparative analysis of low-power versus high-power holmium laser enucleation of the prostate for symptomatic small-volume benign prostatic hyperplasia: a prospective randomized controlled trial.

Objective: To compare the safety and efficacy of low-power (LP) and high-power (HP) holmium laser enucleation of the prostate (HoLEP) in patients with symptomatic small-volume benign prostatic hyperplasia (BPH).

Methods: In this prospective, multicenter, single-blind, randomized controlled trial, men with symptomatic BPH (prostate volume <40 mL, peak urinary flow rate [Qmax] <10 mL/s, International Prostate Symptom Score [IPSS] ≥18) underwent either LP (24 W) or HP HoLEP (80 W). The primary outcome was IPSS at 6 months postoperatively.

Senescence Reprogramming by MTHFD2 Deficiency Facilitates Tumor Progression.

Age is a critical risk factor for cancer, as its incidence and mortality increase with age. However, there is limited understanding of the molecular changes aging induces in tumors. We explored demographic differences between young and old cancer patients and identified age sixty and above as pivotal in cancer prognosis.

Characterization and complete genome sequence of a novel zetapatitivirus from Penicillium exsudans isolate RCEF7900.

Penicillium exsudans strain RCEF7900, obtained from leaf litter, was found to harbor two double-stranded RNA (dsRNA) elements, designated as dsRNA1 and dsRNA2, with lengths of 1,816 bp and 1,625 bp, respectively. dsRNA1 encodes a 572-amino-acid RNA-dependent RNA polymerase (RdRp) protein (65.29 kDa), while dsRNA2 encodes a 503-amino-acid coat protein (CP) (56.

Neural functional rehabilitation: exploring neuromuscular reconstruction technology advancements and challenges.

Neural machine interface technology is a pioneering approach that aims to address the complex challenges of neurological dysfunctions and disabilities resulting from conditions such as congenital disorders, traumatic injuries, and neurological diseases. Neural machine interface technology establishes direct connections with the brain or peripheral nervous system to restore impaired motor, sensory, and cognitive functions, significantly improving patients' quality of life. This review analyzes the chronological development and integration of various neural machine interface technologies, including regenerative peripheral nerve interfaces, targeted muscle and sensory reinnervation, agonist-antagonist myoneural interfaces, and brain-machine interfaces.

Impacts of Climate Change Conditions on the Potential Distribution of and Its Host Plants, and , in China.

The (Motschulsky) is a phytophagous pest that is seriously endangering Linn. and Koidz. Poor control can damage local ecosystems, resulting in economic losses and management risks.

Composition-Graded Nitride Ferroelectrics Based Multi-Level Non-Volatile Memory for Neuromorphic Computing.

Multi-level non-volatile ferroelectric memories are emerging as promising candidates for data storage and neuromorphic computing applications, due to the enhancement of storage density and the reduction of energy and space consumption. Traditional multi-level operations are achieved by utilizing intermediary polarization states, which exhibit an unpredictable ferroelectric domain switching nature, leading to unstable multi-level memory. In this study, a unique approach of composition-graded ferroelectric ScAlN to achieve tunable operating voltage in a wide range and attain precise control of domain switching and stable multi-level memory is proposed.

Astragalus polysaccharide/carboxymethyl chitosan/sodium alginate based electroconductive hydrogels for diabetic wound healing and muscle function assessment.

Natural polysaccharides with excellent biocompatibility are considered ideal materials for repairing diabetic foot ulcer. However, diabetic foot ulcer is often accompanied by decreased muscle function, even resulting in muscle atrophy. During wound repair, monitoring muscle function at the wound site in real time can identify the decreased muscle strength timely, which is crucial for precise wound rehabilitation.

Anti-seepage reinforcement property and pollution control effect of bio-cemented fracture zone in electrolytic manganese residue dump.

The heavy metal (HM) pollutants in electrolytic manganese residue (EMR) can easily diffuse through the seepage channel of the dump under the leaching action of rainfall. Particularly, the fracture zone, as one of the widely distributed seepage channels in the manganese residue dump (MRD), poses a greater threat to the ecological environment due to its weak mechanical properties, strong ductility, and numerous fractures. In this study, the microbially induced calcium carbonate precipitation (MICP) method was used for anti-seepage reinforcement of the fracture zone in an MRD to be constructed.