Publications by authors named "Ping Shi"

Objectives: In view of the gradual rejuvenation and acceleration of lumbar spondylosis, a wearable powered lumbar exoskeleton based on a 6-SPU/SP parallel mechanism is designed based on the rehabilitation treatment method of lumbar forward flexion/extension, left/right lateral flexion and rotation.

Methods: First, the changes in human lumbar muscles are analyzed based on human biomechanics, and then the prototype design of the powered lumbar exoskeleton is implemented, including the mechanical mechanism design, and hardware module design. Finally, the simulation experiment of muscle force and output sensitivity test in the resistive mode are conducted.

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The atypical development in children with autism spectrum disorder (ASD) may cause varying degrees of gait deficits, characterized by uncoordinated and peculiar postures. However, these symptoms are often ignored due to their subtlety. This study aimed to quantify the atypical gait pattern in ASD and explore the feasibility of a gait-based method for ASD recognition.

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Urinary incontinence is closely related to the motor ability and toileting tasks. Some nursing home residents with limited mobility who cannot reach the bathroom in time highly depend on caregivers for toileting assistance. However, nursing home staffing is often insufficient to meet the needs of all residents.

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Background: Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease. Given its rapid disease progression and high mortality rate, early warning is crucial in improving the outcomes, However, to date, relevant comprehensive predictors or an effective prediction model are still poorly explored.

Methods: A plasma proteomic profile was performed at early stages in patients with SFTS.

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Background: Lumbar disc herniation (LDH) occurs when the nucleus pulposus or annulus fibrosus protrudes into the intervertebral space, potentially compressing nerve roots and causing symptoms such as sciatica, restricted mobility, and lower extremity weakness. The development of portable lumbar exoskeleton devices offers a new approach, combining traction, range of motion (ROM) exercises, and resistance training in a single system, potentially reducing treatment complexity and enhancing LDH patient outcomes.

Objective: This study aims to evaluate the efficacy and safety of a novel lumbar exoskeleton device compared to traditional traction methods combined with rehabilitation therapy for patients with LDH.

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Proteolysis targeting chimeras (PROTACs) are pivotal in cancer therapy for their ability to degrade specific proteins. However, their non-specificity can lead to systemic toxicity due to protein degradation in normal cells. To address this, we have integrated a nanobody into the PROTACs framework and leveraged the tumor microenvironment to enhance drug specificity.

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Purpose: Nivolumab plus ipilimumab (NIVO + IPI) is a first-in-class combination immunotherapy for the treatment of intermediate- or poor (I/P)-risk advanced or metastatic renal cell carcinoma (mRCC). Currently, there are limited real-world data regarding clinical effectiveness beyond 12-24 months from treatment initiation. In this real-world study, treatment patterns and clinical outcomes were evaluated for NIVO + IPI in a community oncology setting.

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Aim: The objective of the present study was to investigate the clinical understanding and reasoning abilities of large language models (LLMs); namely, ChatGPT, GPT-4, and New Bing, by evaluating their performance in the NDLE (National Dental Licensing Examination) in China.

Materials And Methods: Questions from the NDLE from 2020 to 2022 were selected based on subject weightings. Standardized prompts were utilized to regulate the output of LLMs for acquiring more precise answers.

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Synthetic cannabinoids (SCs) are an evolving class of new psychoactive substances (NPS) with structurally various compounds that are increasing over the past few years. Therefore, they are initially hard to identify because of the lack of analytical information. Moreover, there is little to no information regarding the pharmacology of these compounds despite human abuse.

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Tonsillar marginal zone hyperplasia may mimic mucosa-associated lymphoid tissue lymphoma, a rare diagnosis in children. Histologically, both entities can demonstrate expansion of the marginal zone with disruption of follicular architecture. However, marginal zone hyperplasia may appear polyclonal by flow cytometry.

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Transcutaneous electrical nerve stimulation (TENS) has been used to treat chronic pain. However, the potential efficacy and mechanism of the effect of applying TENS for a short time in chronic pain patients remains unclear. To identify the effect of short-term TENS on chronic pain patients and to clarify the mechanism of the effect, we investigated abnormalities of functional connectivity (FC) within the prefrontal cortex (PFC) using resting-state functional near-infrared spectroscopy (rs-fNIRS).

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Objective: To investigate the effect of miR-2110 on the biological behaviors, such as cell proliferation, apoptosis, and metastasis, of lung adenocarcinoma (LUAD) cells by means of cell and animal experiments.

Methods: Bioinformatics websites, including ENCORI, TargetScan, miRTarBase, and Tarbase, were used to analyze the changes in the expression of miR-2110 in LUAD samples and to predict miR-2110 target. LUAD tissue samples and cells were collected and the changes in the expression of miR-2110 were verified through PCR technology.

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The inherent limitations of native starch considerably restrict its applications in the food industry. To enhance its processing properties, Arenga pinnata (Wurmb.) Merr.

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Article Synopsis
  • Anaplastic thyroid carcinoma (ATC) is a rare and serious type of cancer that affects the thyroid gland, and researchers are studying a protein called DIAPH3 to see how it affects this cancer.
  • They used different tests to find out how DIAPH3 interacts with another protein, FOXM1, and how this affects cancer cells' ability to grow and spread.
  • The results showed that DIAPH3 helps ATC cells become more aggressive and that it works with FOXM1 to promote cell growth and prevent cell death, making the cancer harder to treat.
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Background: With its rapidly increasing incidence and prevalence, ulcerative colitis (UC) has become a major global health challenge. Recent evidence suggests that ferroptosis plays a significant role in the development of UC. However, the relationship between ferroptosis and the progression of UC needs to be extensively studied.

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In order to improve the processing and digestibility of the Arenga pinnata (Wurmb.) Merr. starch (APS), low concentration citric acid (CA) and chitosan (CS) were used for dual modification.

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Previous studies on BSC2 have shown that it enhances yeast cell resistance to AmB via antioxidation and induces multidrug resistance by contributing to biofilm formation. Herein, we found that BSC2 overexpression could reverse the sensitivity of pmp3Δ to AmB and help the tested strains restore the intracellular sodium/potassium balance under exposure to AmB. Meanwhile, overexpression of the chitin gene CHS2 could simulate BSC2 to reverse the sensitivity of pmp3Δ and nha1Δ to high salt or AmB.

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Background: Epstein-Barr virus (EBV) can be reactivated and proliferated with fatal outcome in immuno-compromised people, but the clinical consequences of EBV infection in patients with severe fever with thrombocytopenia syndrome (SFTS) remain uncertain. In this study, we investigated the infection rate, the influence and the early predictors of EBV infection in SFTS patients.

Methods: In this retrospective study, SFTS patients who were treated in the First Affiliated Hospital of Nanjing Medical University from May 2011 to August 2021 were enrolled and divided into infected and non-infected groups.

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In order to avoid the disadvantages of the Fenton process in wastewater treatment and reduce the cost of wastewater treatment, a series of MIL-101(Fe)-X (X = -OH, -NH, -NO, -H) solid Fenton catalysts were successfully prepared. The performance of these Fenton-like catalysts was studied with the Fenton experiment as a reference and methylene blue (MB) as an organic pollutant. The effects of the HO concentration, catalyst dosage, and reaction pH on catalytic performance were systematically studied.

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Autosomal recessive non-syndromic hearing loss (ARNSHL) can cause severe or very severe pre-speech hearing loss. Transmembrane channel-like 1 (TMC1) gene is the sixth deafness gene discovered, but the precise extent of its protein structure and function is unknown. First, history collection, audiology examination and imaging examination were performed on the proband and his family members.

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Micro/nanomotors represent a promising class of drug delivery carriers capable of converting surrounding chemical or external energy into mechanical power, enabling autonomous movement. Their distinct autonomous propulsive force distinguishes them from other carriers, offering significant potential for enhancing drug penetration across cellular and tissue barriers. A comprehensive understanding of micro/nanomotor dynamics with various power sources is crucial to facilitate their transition from proof-of-concept to clinical application.

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Article Synopsis
  • This study looked at how wearable back support called exoskeletons help protect our spine when carrying heavy stuff with one shoulder.
  • They tested ten young guys and measured how their spines moved and how much pressure was on their feet while they carried different weights.
  • The results showed that using the exoskeleton helped keep their spine safe when carrying things on one shoulder, but it didn't make a big difference in some of the spine movements when they had even more support.
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Background: Colonoscopy is essential for diagnosing colorectal diseases but can cause pain during the procedure. This study explored the analgesic effects of transcutaneous electrical nerve stimulation based on wrist-ankle acupuncture theory (TENS-WAA) in colonoscopy without anesthesia.

Methods: This prospective study included 120 participants undergoing colonoscopies without anesthesia.

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