Impacts of food additives on gut microbiota and host health.

The rapidly expanding food industry necessitates the use of food additives to achieve specific purposes. However, this raises new concerns in food safety due to the reported negative impacts of food additives on gut microbiota and host health, particularly in the context of continuous worldwide urbanization. This review summarizes the existing studies on the effects of different types of commonly used food additives on gut microbiota alteration, intestinal barrier disruption, metabolism disorder, and neurobehavior changes.

CaCO-complexed pH-responsive nanoparticles encapsulating mitoxantrone and celastrol enhance tumor chemoimmunotherapy.

Modulating the immunosuppressive tumor microenvironment (TME) while enhancing antitumor immune responses is a promising strategy. In this study, we designed an acid-sensitive nanosystem (MCCaNPs) to demonstrate effective immunotherapy against cancer through the systemic delivery of immune-stimulating chemotherapy combinations. A pH-responsive nanoplatform containing CaCO was prepared by the double emulsion method, and mitoxantrone (MIT) and celastrol (CEL) were simultaneously encapsulated as immunogenic cell death (ICD) inducers.

Discovery of Novel Isoquinoline Analogues as Dual Tubulin Polymerization/V-ATPase Inhibitors with Immunogenic Cell Death Induction.

Cancer immunotherapy has revolutionized clinical advances in a variety of cancers. Due to the low immunogenicity of the tumor, only a few patients can benefit from it. Specific microtubule inhibitors can effectively induce immunogenic cell death and improve immunogenicity of the tumor.

Gardenia Iridoid Glucosides Protect Against α-Naphthalene Isothiocya-Nate-Induced Cholestatic Rats Through Activation of the FXR-SHP Signaling Pathway.

Introduction: Cholestasis is a common liver disorder that currently has limited treatment options. Gardenia Iridoid Glucosides (GIG) have been found to possess various physiological activities, such as cholagogic, hypoglycemic, antibacterial, and anti-inflammatory effects. The objective of this study was to investigate the effects of GIG on bile acid enterohepatic circulation and explore the underlying mechanism in cholestatic rats.

Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors.

Synergistic chemotherapy and photothermal therapy (PTT) holds the promise of addressing the weakness of individualized chemotherapy and PTT. In this study, we synthesized a chemotherapeutic agent, PDA-Ce-CDs, which combines the photothermal conversion ability and the generation of hydroxyl radicals (•OH), enabling synergistic enhancement of antitumor effects. Furthermore, the localized heating effect of NIR radiation promoted the uptake of the PDA-Ce-CDs and enhances the sensitivity of intracellular reactive oxygen species (ROS).

Evolution of channel flow and Darcy's law beyond the critical Reynolds number.

For incompressible channel flow, there is a critical state, characterized by a critical Reynolds number Re and a critical wavevector m along the channel direction, beyond which the channel flow becomes unstable in the linear regime. In this work, we investigate the channel flow beyond the critical state and find the existence of a new fluctuating, quasi-stationary flow that comprises the laminar Poiseuille flow superposed with a counter-flow component, accompanied by vortices and anti-vortices. The net flow rate is reduced by  ~ 15% from the linear, laminar regime.

Hypoxia-responsive Immunostimulatory Nanomedicines Synergize with Checkpoint Blockade Immunotherapy for Potentiating Cancer Immunotherapy.

Inducing cell death while simultaneously enhancing antitumor immune responses is a promising therapeutic approach for multiple cancers. Celastrol (Cel) and 7-ethyl-10-hydroxycamptothecin (SN38) have contrasting physicochemical properties, but strong synergy in immunogenic cell death induction and anticancer activity. Herein, a hypoxia-sensitive nanosystem (CS@TAP) was designed to demonstrate effective immunotherapy for colorectal cancer by systemic delivery of an immunostimulatory chemotherapy combination.

LiMYB108 is involved in floral monoterpene biosynthesis induced by light intensity in Lilium 'Siberia'.

We find that the MYB family transcription factor, LiMYB108, has a novel function to regulate the floral fragrance affected by light intensity. Floral fragrance determines the commercial value of flowers and is influenced by many environmental factors, especially light intensity. However, the mechanism by which light intensity affects the release of floral fragrance is unclear.

Ultrasensitive electrochemical aptasensor with Nafion-stabilized f-MWCNTs as signal enhancers for OTA detection.

In this study, an ultrasensitive electrochemical (EC) aptasensor with Nafion-stabilized functionalized multi-walled carbon nanotubes (f-MWCNTs) as signal enhancers was established for ochratoxin A (OTA) determination. Herein, f-MWCNTs were prepared through functionalization with nitric acid. The incorporation of Nafion promoted a good dispersion of f-MWCNTs and prevented their leaching on the electrode, making a robust stability of the aptasensor.

Discovery of Novel -Heterocyclic-Fused Deoxypodophyllotoxin Analogues as Tubulin Polymerization Inhibitors Targeting the Colchicine-Binding Site for Cancer Treatment.

Natural products are a major source of anticancer agents and play critical roles in anticancer drug development. Inspired by the complexity-to-diversity strategy, novel deoxypodophyllotoxin (DPT) analogues were designed and synthesized. Among them, compound exhibited the potent antiproliferative activity against four human cancer cell lines with IC values in the low nanomolar range.

Development of a Nafion-MWCNTs and in-situ generated Au nanopopcorns dual-amplification electrochemical aptasensor for ultrasensitive detection of OTA.

Trace detection of ochratoxin A (OTA) in foods is essential to mitigate risks to human health. Herein, a label-free electrochemical (EC) aptasensor based on dual-signal amplification of Nafion dispersed multi-walled carbon nanotubes (Nafion-MWCNTs) and Au nanopopcorns was developed for ultrasensitive detection of OTA. Nafion solution prevented the leaching of MWCNTs, and the Nafion-MWCNTs modified screen-printed carbon electrode (SPCE) acted as the sensing substrate which facilitated the uniform distribution of the electrodeposited Au nanopopcorns.

Muscone suppresses myocardial ischemia damage by regulating PI3K/Akt signaling pathway.

Muscone is the main active compound of Moschus. In this paper, the cardioprotective effect of Muscone on acute myocardial ischemia (AMI) rats and its potential mechanisms were investigated. AMI rat models were established to evaluate the protective effect and antioxidative function of Muscone on the hearts.

Cardioprotective Effects of Tetrahydropalmatine on Acute Myocardial Infarction in Rats.

Tetrahydropalmatine (THP) is an active component of . The current study investigates the possible cardioprotective effects of tetrahydropalmatine in acute myocardial ischemia (AMI) rats. The anterior descending coronary artery of SD rats was ligated to establish an AMI model.

Comparing willingness-to-pay and time-trade-off as the measures of burden of psoriasis: A pooled analysis of community, hospital, and web-based samples in China.

Willingness-to-pay (WTP) and time-trade-off (TTO) are widely used as measures of disease burden. However, the sensitivity of the metrics has not been compared in psoriasis. This article aims to report WTP and TTO in Chinese psoriasis patients, and to compare the WTP (USD), WTP (%), and TTO regarding the sensitivity in measuring the burden of psoriasis.

m6A regulators are differently expressed and correlated with immune response of pancreatic adenocarcinoma.

Background: N6 methyladenosine (m6A) RNA methylation regulators play a key role in the occurrence and development of many tumors. However, the function of N6 methyladenosine (m6A) RNA methylation regulators in pancreatic adenocarcinoma (PAAD) has not been fully clarified.

Methods: We used data set from GEPIA 2, UALCAN, TIMER, TISIDB, CBioPortal database to analyze the gene expression of 20 major m6A RNA methylation regulators.

Underwater metamaterial absorber with impedance-matched composite.

By using a structured tungsten-polyurethane composite that is impedance matched to water while simultaneously having a much slower longitudinal sound speed, we have theoretically designed and experimentally realized an underwater acoustic absorber exhibiting high absorption from 4 to 20 kHz, measured in a 5.6 m by 3.6 m water pool with the time-domain approach.

The Transcriptomic Mechanism of a Novel Autolysis Induced by a Recombinant Antibacterial Peptide from Chicken Expressed in .

Autolysis is a common physiological process in eukaryotic cells that is often prevented or applied, especially in yeast expression systems. In this study, an antimicrobial peptide from chicken (AMP) was recombinantly expressed in the expression system, which induced a series of cellular autolysis phenotypes after methanol treatment, such as the aggregated, lysed, irregular, and enlarged cell morphology, while the cells expressing a recombinant aflatoxin-detoxifizyme (ADTZ) were not autolyzed. A comparative transcriptomic analysis showed that the transcriptomic profiles of cells derived from the autolysis and non-autolysis groups were well discriminated, suggesting that the mechanisms of autolysis were at the transcriptional level.

Aptasensors for mycotoxins in foods: Recent advances and future trends.

Mycotoxin contamination in foods has posed serious threat to public health and raised worldwide concern. The development of simple, rapid, facile, and cost-effective methods for mycotoxin detection is of urgent need. Aptamer-based sensors, abbreviated as aptasensors, with excellent recognition capacity to a wide variety of mycotoxins have attracted ever-increasing interest of researchers because of their simple fabrication, rapid response, high sensitivity, low cost, and easy adaptability for in situ measurement.

Mechanical Properties and Heat Transfer Performance of Conically Corrugated Tube.

Conically corrugated tube is a new type of high-efficiency heat exchange tube. In this paper, the mechanical and heat transfer properties of conically corrugated tubes formed by the cold rolling of smooth tubes are studied through experimental measurement and numerical simulation to lay the foundations for applying the tubes in heat exchangers. The results show that while conically corrugated tube has a lower axial elastic stiffness compared with smooth tube, conically corrugated tube has a higher yield strength and ultimate strength.

Conceptual-based design of an ultrabroadband microwave metamaterial absorber.

By introducing metallic ring structural dipole resonances in the microwave regime, we have designed and realized a metamaterial absorber with hierarchical structures that can display an averaged -19.4 dB reflection loss (∼99% absorption) from 3 to 40 GHz. The measured performance is independent of the polarizations of the incident wave at normal incidence, while absorption at oblique incidence remains considerably effective up to 45°.

The effect of extract on in vitro ruminal fermentation and methanogenesis.

Methane production is the main gas energy loss in ruminants and generates a powerful greenhouse gas that contributes to climate changes. is a plant commonly utilized additive in livestock diet as it contains various chemical compounds with beneficial health effects. This study aimed to explore the influence of extract on in vitro methanogenesis and rumen fermentation.

Correlation in thermal fluctuations induced by phase-locked hydrodynamic modes.

Thermal fluctuations constitute a fundamental equilibrium phenomenon whose spatial and temporal correlations are governed by the relevant scales of molecular collisions. From the continuum point of view, thermal fluctuations in a fluid can be regarded as comprising a multitude of hydrodynamic modes (HMs) with random phases, each one having one degree of freedom. We show that in a two-dimensional fluid channel with the Navier slip boundary condition, in which the HMs are represented by periodic arrays of vortex and antivortex pairs, periodic modulation of the slip boundary condition can selectively suppress noncommensurate HMs while phase lock the remaining eigenmodes.

Monitoring the Setting Process of Cementitious Materials Using Guided Waves in Thin Rods.

Characterizing early-age properties is very important for the quality control and durability of cementitious materials. In this paper, an approach using embedded guided waves was adopted to monitor the changes in the mechanical proprieties of mortar and concrete during setting, and embedded thin rods with low-cost piezoelectric sensors mounted on top were used for guide wave monitoring. Through continuous attenuation monitoring of the guided waves, the evolution of mortar and concrete properties was characterized.

A Focus on Two Electrokinetics Issues.

This review article intends to communicate the new understanding and viewpoints on two fundamental electrokinetics topics that have only become available recently. The first is on the holistic approach to the Poisson-Boltzmann equation that can account for the effects arising from the interaction between the mobile ions in the Debye layer and the surface charge. The second is on the physical picture of the inner electro-hydrodynamic flow field of an electrophoretic particle and its drag coefficient.

[Study on residues of heavy metals and harmful elements in Qingqiao and Laoqiao based on chemometrics].

Forsythiae Fructus is divided into Qingqiao and Laoqiao due to different harvesting periods. So far, the accumulation of heavy metals in the two types of Forsythiae Fructus has not been reported. In this study, the residual levels of copper(Cu), lead(Pb), chromium(Cr), arsenic(As), cadmium(Cd) and mercury(Hg) in 29 batches of Laoqiao and 60 batches of Qingqiao were determined by inductively coupled plasma mass spectrometry(ICP-MS).