Engineering p-Orbital States via Molecular Modules in All-Organic Electrocatalysts toward Direct Water Oxidation.

Oxygen evolution reaction (OER) is an indispensable anode reaction for sustainable hydrogen production from water electrolysis, yet overreliance on metal-based catalysts featured with vibrant d-electrons. It still has notable gap between metal-free and metal-based electrocatalysts, due to lacking accurate and efficient p-band regulation methods on non-metal atoms. Herein, a molecular modularization strategy is proposed for fine-tuning the p-orbital states of series metal-free covalent organic frameworks (COFs) for realizing OER performance beyond benchmark precious metal catalysts.

Pattern of colorectal surgery and long-term survival: 10-year experience from a single center.

Background: The incidence of colorectal cancer (CRC) has increased in recent decades, and ranks fourth among males and third among females in China. Surgical resection remains the most important treatment modality for curative intent in CRC. Several studies found that surgeon volumes and specialization appeared to be associated with improved overall survival (OS).

Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer.

Immune checkpoint blockade therapy with anti-PD-1 monoclonal antibody (mAb) is a treatment for colorectal cancer (CRC). However, some patients remain unresponsive to PD-1 blockade. The gut microbiota has been linked to immunotherapy resistance through unclear mechanisms.

A bioinformatics analysis: ZFHX4 is associated with metastasis and poor survival in ovarian cancer.

Background: Metastasis was the major cause of the high mortality in ovarian cancer. Although some mechanisms of metastasis in ovarian cancer were proposed, few have been targeted in the clinical practice. In the study, we aimed to identify novel genes contributing to metastasis and poor clinical outcome in ovarian cancer from bioinformatics databases.

Operable hepatitis B virus-related hepatocellular carcinoma: gut microbiota profile of patients at different ages.

Background: Age was important prognostic factors for operable hepatocellular carcinoma patients. The aim of the present study was to assess the difference in gut microbiota in patients with operable hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) at different ages ; to investigate the features of the microbiota and its function associated with different ages; to provide a preliminary look at effects of the gut microbiota dimension on prognostic.

Methods: From September 2020 to May 2021, patients with HBV-HCC were able to undergo liver resection and were recruited consecutively and divided into the younger age group (age <45 years) (Y.

cGAS-STING-mediated IFN-I Response in Host Defense and Neuroinflammatory Diseases.

The presence of foreign or misplaced nucleic acids is a dangerous signal that triggers innate immune responses by activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid-sensing to immune responses and pathogenic entities clearance. However, the overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflammatory diseases.

Vertical differentiation of soil organic carbon in mature natural forests in China.

We analyzed the effects of meteorological factors and soil properties on vertical variation of SOC, based on soil organic carbon (SOC) density in different soil layers (0-10, 10-20, 20-30, 30-50, and 50-100 cm) from 131 mature natural forests in different climate zones in China. The results showed that SOC density decreased with increasing soil depth (0-30 cm) in temperate coniferous, temperate deciduous broadleaved, subtropical deciduous broadleaved and subtropical evergreen broadleaved forests. There were significant regional variations of SOC density in 0-100 cm soil layer.

Recycling waste thermosetting unsaturated polyester resins into oligomers for preparing amphiphilic aerogels.

The styrene-maleic acid copolymer (SMC) was obtained by selective and complete cleavage of ester groups from waste thermosetting unsaturated polyester resins (WTUPR). The degradation was performed in glycol at 180 °C for 5 h with potassium carbonate as a catalyst and the resultant potassium salt of SMC (SMC-K) can be very easily separated by precipitation using ethanol with a yield of 63.8%.

lipopolysaccharide (Pg-LPS) influences adipocytes injuries through triggering XBP1 and activating mitochondria-mediated apoptosis.

Obesity is an important public-health problem worldwide. This study aimed to determine effects of porphyromonas gingivalis lipopolysaccharide (Pg-LPS) on adipocytes injuries and explore associated mechanisms. Adipocytes were isolated from SD rats.

Prognostic impact of and mutations in patients who underwent simultaneous resection for initially resectable colorectal liver metastases.

This study aimed to explore the prognostic impact of and mutations in patients who underwent simultaneous resection for synchronous colorectal liver metastases (SCRLMs) that were initially resectable. Clinicopathological and outcome data of 139 consecutive patients with SCRLMs who underwent resection between July 2003 and July 2013 was collected from our prospectively established SCRLM database. The and genotypes were evaluated in the primary cancer tissues by pyrosequencing.

CYP2C19 polymorphism has no correlation with the efficacy and safety of thalidomide in the treatment of immune-related bowel disease.

Objective: To explore the relationship between hepatic cytochrome P450 2C19 (CYP2C19) gene polymorphisms and the effectiveness and safety of thalidomide in the treatment of patients with immune-related bowel disease (IRBD).

Methods: CYP2C19 variants in 79 patients treated with thalidomide were analyzed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The clinical response and adverse events of the thalidomide treatment were recorded.

Fast microwave-assisted hydrolysis of unsaturated polyester resin into column packing for rapid purifying of dye wastewater.

Microwave-assisted selective degradation successfully converts thermosetting unsaturated polyester resins into a low-swelling (below 10 g g) gel material (GM) with a high yield (58-65%) in water at 100°C for only 1 h. The obtained GM possesses rough and porous structure while the content of carboxylate group obtained by cleavage of partial ester groups is more than 10%, varying with the concentration of the catalyst. It is suitable for use as packing of adsorption column to rapidly purify sewage.

LAPTM5 is transactivated by RUNX2 and involved in RANKL trafficking in osteoblastic cells.

The present study aimed to investigate the role of lysosomal‑associated transmembrane protein 5 (LAPTM5) in osteoclast differentiation induced by osteoblasts. The results demonstrated that the expression levels of LAPTM5 were downregulated following runt‑related transcription factor 2 (RUNX2) silencing and upregulated following RUNX2 overexpression in ST2 cells. Chromatin immunoprecipitation analysis identified the binding of RUNX2 to the LAPTM5 promoter at the ‑1176 to ‑1171 position.

Autofluorescence of hydrogels without a fluorophore.

Fluorescent hydrogels have recently attracted great attention for medical diagnostics, bioimaging and environmental monitoring. However, additional phosphors or fluorophores are always required to label the hydrogels, and they suffer from marker bleaching, signal drifts, or information misrepresentation. Here we report autofluorescence that universally exists in carbonyl-containing hydrogels without any traditional fluorophore.

Thalidomide induces clinical remission and mucosal healing in adults with active Crohn's disease: a prospective open-label study.

Background: Thalidomide is effective in inducing and maintaining clinical remission in children and adolescents with refractory Crohn's disease (CD). However, little is known about the efficacy and safety of thalidomide for adult patients with CD.

Methods: We conducted a prospective open-label cohort study between January 2013 and April 2015.

Magnitude-dependent response of osteoblasts regulated by compressive stress.

The present study aimed to investigate the role of magnitude in adaptive response of osteoblasts exposed to compressive stress. Murine primary osteoblasts and MC3T3-E1 cells were exposed to compressive stress (0, 1, 2, 3, 4, and 5 g/cm) in 3D culture. Cell viability was evaluated, and expression levels of Runx2, Alp, Ocn, Rankl, and Opg were examined.

[Effects of a Symbiotic Bacterium on the Accumulation and Transformation of Arsenate by ].

Algae-bacteria consortia may be potentially applied in wastewater treatment and environment remediation. In this study, in order to investigate effects of a symbiotic bacterium on the accumulation and transformation of arsenate[As(Ⅴ)] by , we used batch cultures to determine the uptake, adsorption and transformation of As by axenic and non-axenic exposed to 0-750 μg·L As(Ⅴ) for 7 d. The symbiotic bacterium of was confirmed to be sp.

[Impact of particle size and morphology on zinc cation adsorption by hydroxyapatite and dentifrice containing hydroxyapatite].

Objective: To study the influence of particle size and morphology on zinc cation adsorption by hydroxyapatite (HA) and dentifrice containing HA.

Methods: Four HAs with different particle sizes and morphologies, HA-containing dentifrice and blank dentifrice were prepared into suspensions of serial concentrations. Zinc ion solutions with an initial concentration of 10 mg/L was mixed with the suspensions and kept for 24 h for adsorption reaction.

Anti-inflammatory diterpenoids from the root bark of Acanthopanax gracilistylus.

Five new ent-pimarane (1-3, 7, and 8) and three new ent-kaurane diterpenoids (4-6) and a new oleanane triterpene acid (9), together with 22 known compounds, were isolated from the root bark of the medicinal herb Acanthopanax gracilistylus. The structures of 1-9 were established based on the interpretation of high-resolution MS and 1D- and 2D-NMR data. The absolute configurations of 7 and 11 were determined by single-crystal X-ray diffraction and electronic circular dichroism analysis.

Effects of temperature and wavelength choice on in-situ dissolution test of Cimetidine tablets.

The effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance ()<1.0 is required when using a fiber-optic dissolution test system.

Chemical constituents of Spatholobus suberectus.

Aim: To investigate chemical constituents of Spatholobus suberectus Dunn.

Methods: Isolation and purification were carried out by column chromatographic methods. Compounds were characterized based on their physical characteristics and spectra data.

[Impact of surgical modalities for gastric cancer on operational trauma].

Objective: To evaluate the impact of surgical modality for gastric cancer on operational trauma.

Methods: A total of 1499 cases of gastric cancer undergoing surgical procedures were divided into the groups of radical resection (RR, n = 1344) and palliative resection group (NRR, n = 155) according to their surgical modalities. And they were further divided into sub-groups according to the profiles of gastrectomy, extent of lymphadenectomy and multi organic resection.

Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system.

The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying. In this study, the technique of differential spectra was employed, which made it possible to monitor the dissolution testing in situ.

High expression of the autophagy gene Beclin-1 is associated with favorable prognosis for salivary gland adenoid cystic carcinoma.

Background: Although autophagy is universally involved in tumorigenesis and tumor progression, the roles of autophagy and autophagy-regulating genes in salivary gland adenoid cystic carcinoma (ACC) remain unknown. In this study, we investigated the expression of the autophagy-regulating genes Beclin-1, death-associated protein kinase-1, ultraviolet radiation resistance-associated gene, and phosphatase and tensin homolog in salivary gland ACC samples.

Methods: Immunohistochemistry and real-time polymerase chain reaction were used to analyze the expression of these genes in 89 ACC samples and normal salivary gland tissue samples.