Corrigendum: Apigenin protects against ischemic stroke by increasing DNA repair.

[This corrects the article DOI: 10.3389/fphar.2024.

Effect and mechanism of Dichloroacetate in the treatment of stroke and the resolution strategy for side effect.

Stroke is a serious disease that leads to high morbidity and mortality, and ischemic stroke accounts for more than 80% of strokes. At present, the only effective drug recombinant tissue plasminogen activator is limited by its indications, and its clinical application rate is not high. Therefore, it is urgent to develop effective new drugs according to the pathological mechanism.

Two-dimensional single-crystal periodic macroporous ZnO sheets for extraordinary photocatalytic performance for antibiotics.

Periodic macropores are extensively utilized in the design of photocatalytic materials owing to their capacity to enhance the availability of active sites, shorten carrier migration distances, and improve mass transfer efficiency. However, their three-dimensional periodic structure, primarily composed of stacked nanoparticles, may not be fully utilized due to pore channel blockage. Additionally, the numerous grain boundaries greatly increase the recombination probability of photogenerated electrons and holes.

Periodic Macroporous KTaO Fabricated for Photocatalytic Hydrogen Production from Pure Water Splitting.

Periodic macroporous materials are extensively utilized in photocatalytic hydrogen production from water splitting owing to their smooth mass transfer and abundant active sites. Therefore, it is essential to develop highly stable materials featuring interconnected channels and appropriate surface states to enhance the photocatalytic capability. Periodic macroporous KTaO (PM-KTaO) with a pyrochlore structure emerges as the ideal candidate to fulfill these requirements.

The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection.

IAA is a by-product of the water disinfection process and has been found to be neurotoxic. However, the role and mechanism of IAA neurotoxicity remain unclear. In this review, we comprehensively discuss the neurotoxic effects and mechanisms of IAA from the molecular level, cellular level and neurological manifestations.

Investigating students' perceptions of the medical education environment and learning autonomy in blended learning in pediatrics: a cross-sectional study.

Background: In the process of education reform, carrying out continuous educational environment measurement is necessary. This study aimed to evaluate the perceptions of the medical education environment and learning autonomy in blended learning in pediatrics among clinical medicine students, as well as the relationship between these two constructs.

Methods: A cross-sectional study was conducted on clinical medical students from the First Clinical School of Wuhan University who had completed the blended learning courses of pediatrics.

Functionalized Nanozyme Microcapsules Targeting Deafness Prevention via Mitochondrial Homeostasis Remodeling.

Mitochondrial dysfunction, which is the primary mechanism underlying cisplatin-induced hearing loss, can potentially be mitigated by modulating the redox balance and reprogramming the energy metabolism to remodel mitochondrial homeostasis. Herein, N-acetyl-l-cysteine-derived carbonized polymer dots (NAC CPDs) are embedded into manganese porphyrin-doped metal-organic frameworks and encapsulated using a polydopamine (PDA) coating and gelatin methacryloyl (GelMA) hydrogel to afford functionalized nanozyme microcapsules. Owing to their injectability and adhesion properties, these microcapsules exhibit the advantages of prolonged retention in the middle ear and sustained release in the inner ear.

Exploring the design of clinical research studies on the efficacy mechanisms in type 2 diabetes mellitus.

This review examines the complexities of Type 2 Diabetes Mellitus (T2DM), focusing on the critical role of integrating omics technologies with traditional experimental methods. It underscores the advancements in understanding the genetic diversity of T2DM and emphasizes the evolution towards personalized treatment modalities. The paper analyzes a variety of omics approaches, including genomics, methylation, transcriptomics, proteomics, metabolomics, and intestinal microbiomics, delineating their substantial contributions to deciphering the multifaceted mechanisms underlying T2DM.

Apigenin protects against ischemic stroke by increasing DNA repair.

Background And Objective: Oxidative stress is an important pathological process in ischemic stroke (IS). Apigenin (APG) is a natural product with favorable antioxidative effects, and some studies have already demonstrated the antioxidative mechanism of APG in the treatment of IS. However, the mechanism of APG on DNA damage and repair after IS is not clear.

The role of machine learning in advancing diabetic foot: a review.

Background: Diabetic foot complications impose a significant strain on healthcare systems worldwide, acting as a principal cause of morbidity and mortality in individuals with diabetes mellitus. While traditional methods in diagnosing and treating these conditions have faced limitations, the emergence of Machine Learning (ML) technologies heralds a new era, offering the promise of revolutionizing diabetic foot care through enhanced precision and tailored treatment strategies.

Objective: This review aims to explore the transformative impact of ML on managing diabetic foot complications, highlighting its potential to advance diagnostic accuracy and therapeutic approaches by leveraging developments in medical imaging, biomarker detection, and clinical biomechanics.

A Comparative Study of Removal of Acid Red 27 by Adsorption on Four Different Chitosan Morphologies.

To investigate the relationship between structures and adsorption properties, four different morphologies of chitosan, with hydrogel (CSH), aerogel (CSA), powder (CSP), and electrospinning nanofiber (CSEN) characteristics, were employed as adsorbents for the removal of Acid Red 27. The structures and morphologies of the four chitosan adsorbents were characterized with SEM, XRD, ATR-FTIR, and BET methods. The adsorption behaviors and mechanisms of the four chitosan adsorbents were comparatively studied.

Coupling Reliable Interfacial Carrier Migration Channels with Visible-Light Response Antennas in ZnO-Based Heterostructure for Ameliorated Photocatalytic Hydrogen Generation.

Engineering targeted and reliable charge transfer pathways in multiphase photocatalysts remains a challenge. Herein, we conceptualize the Cd@CdS-ZnO/reduced graphene oxide (rGO)/ZnS heterostructures coupled with reliable carrier migration channels and visible-light response antennas by building rGO-integrated electrochemical nanoreactors and an ion-exchange process. In this ternary catalyst, the Cd clusters and rGO perform as charge relays to boost carrier transport via the Z-scheme route and accelerate photogenerated carriers to react with surface-adsorbed substances.

Efficacy and safety of auricular therapy in the treatment of post-stroke constipation: A protocol for systematic review and meta-analysis.

Background: Constipation is one of the common gastrointestinal complications after stroke. It not only aggravates the condition of stroke, but also brings huge medical burden to patients, and has a negative impact on the quality of life of patients. Auricular therapy, as a part of Chinese traditional acupuncture and moxibustion, has been found to be effective in the clinical treatment of constipation.

Highly Crystalline Poly(heptazine imide)-Based Carbonaceous Anodes for Ultralong Lifespan and Low-Temperature Sodium-Ion Batteries.

Carbon nitrides with layered structures and scalable syntheses have emerged as potential anode choices for the commercialization of sodium-ion batteries. However, the low crystallinity of materials synthesized through traditional thermal condensation leads to insufficient conductivity and poor cycling stability, which significantly hamper their practical applications. Herein, a facile salt-covering method was proposed for the synthesis of highly ordered crystalline CN-based all-carbon nanocomposites.

A crystalline carbon nitride-based separator for high-performance lithium metal batteries.

Lithium metal anodes with ultrahigh theoretical capacities are very attractive for assembling high-performance batteries. However, uncontrolled Li dendrite growth strongly retards their practical applications. Different from conventional separator modification strategies that are always focused on functional group tuning or mechanical barrier construction, herein, we propose a crystallinity engineering-related tactic by using the highly crystalline carbon nitride as the separator interlayer to suppress dendrite growth.

Clarifying the mechanism of apigenin against blood-brain barrier disruption in ischemic stroke using systems pharmacology.

Currently, recombinant tissue plasminogen activator (rtPA) is an effective therapy for ischemic stroke (IS). However, blood-brain barrier (BBB) disruption is a serious side effect of rtPA therapy and may lead to patients' death. The natural polyphenol apigenin has a good therapeutic effect on IS.

Pharmacological mechanism and therapeutic efficacy of Icariside II in the treatment of acute ischemic stroke: a systematic review and network pharmacological analysis.

Background And Objective: Epimedii has long been used as a traditional medicine in Asia for the treatment of various common diseases, including Alzheimer's disease, cancer, erectile dysfunction, and stroke. Studies have reported the ameliorative effects of Icariside II (ICS II), a major metabolite of Epimedii, on acute ischemic stroke (AIS) in animal models. Based on network pharmacology, molecular docking, and molecular dynamics (MD) simulations, we conducted a systematic review to evaluate the effects and neuroprotective mechanisms of ICS II on AIS.

Simultaneous detection of circulating tumor DNAs using a SERS-based lateral flow assay biosensor for point-of-care diagnostics of head and neck cancer.

Circulating tumor DNA (ctDNA) has recently emerged as an ideal target for biomarker analytes. Thus, the development of rapid and ultrasensitive ctDNA detection methods is essential. In this study, a high-throughput surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) strip is proposed.

Effective modification of photocatalytic and piezocatalytic performances for poly(heptazine imide) by carbon dots decoration.

As the high-crystalline phase of carbon nitride, poly(heptazine imide) (PHI) has attracted much attention in recent years, considering the more effective light absorption, better charge carrier behavior, and higher surface area of PHI compared with its counterpart with a melon structure that is commonly synthesized through thermal polymerization. Nevertheless, exploring effective strategies to further improve the performance of PHI is still highly desirable. In this work, it is revealed that the photocatalytic as well as piezocatalytic performances of PHI are greatly promoted by coupling with carbon dots (CDots) through a facile ultrasonication process.

Constructing Anatase-Brookite TiO Phase Junction by Thermal Topotactic Transition to Promote Charge Separation for Superior Photocatalytic H Generation.

Phase junctions of photocatalysts can promote the separation of photogenerated charge carriers for efficient utilization of the carriers. Construction of phase junctions and establishing their structure-performance relationship are still required. Herein, polycrystalline TiO decahedral plates with different phases were synthesized by thermal treatment-induced topotactic transition of titanium oxalate crystals.

SERS Based Lateral Flow Assay for Rapid and Ultrasensitive Quantification of Dual Laryngeal Squamous Cell Carcinoma-Related miRNA Biomarkers in Human Serum Using Pd-Au Core-Shell Nanorods and Catalytic Hairpin Assembly.

Non-invasive early diagnosis is of great significant in disease pathologic development and subsequent medical treatments, and microRNA (miRNA) detection has attracted critical attention in early cancer screening and diagnosis. However, it was still a challenge to report an accurate and sensitive method for the detection of miRNA during cancer development, especially in the presence of its analogs that produce intense background noise. Herein, we developed a surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) biosensor, assisted with catalytic hairpin assembly (CHA) amplification strategy, for the dynamic monitoring of miR-106b and miR-196b, associated with laryngeal squamous cell carcinoma (LSCC).

Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway.

Gentamicin (GM) is a commonly used antibiotic, and ototoxicity is one of its side effects. Puerarin (PU) is an isoflavone in kudzu roots that exerts a number of pharmacological effects, including antioxidative and free radical scavenging effects. The present study investigated whether PU could protect against GM‑induced ototoxicity in C57BL/6J mice and House Ear Institute‑Organ of Corti 1 (HEI‑OC1) cells.