Background: Radiotherapy (RT) is an essential treatment for colorectal cancer (CRC), yet the factors influencing radiosensitivity remain unclear. In the quest to enhance the therapeutic efficacy in CRC, the interplay between genetic mutations and RT sensitivity has emerged as a pivotal yet enigmatic area.
Methods: We harness the fidelity of patient-derived organoids (PDOs) to dissect the molecular landscape of radiosensitivity, with a particular emphasis on BRAF mutations.
According to the World Health Organization's statistics, cancer is the second leading cause of death worldwide, following cardiovascular diseases. Despite significant progress in the field of cancer treatment in recent years, cancer remains one of the main factors shortening human life expectancy. The field of cancer research is increasingly focusing on the role of tumor-related oncogenes and heterogeneous proteins in the development of cancer.
View Article and Find Full Text PDFEur Heart J Qual Care Clin Outcomes
February 2025
Aims: This study aimed to investigate the relationship between visceral adipose tissue (VAT), measured using a body shape index (ABSI), and outcomes in patients with heart failure with preserved ejection fraction (HFpEF).
Methods: ABSI data and cardiovascular outcomes were obtained from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial. ABSI was calculated using waist circumference (WC), body mass index, and height.
Purpose: Metabolic characterization of primary angiitis of the central nervous system (PACNS) is crucial for understanding the disease pathogenesis and progression mechanisms, but it has not been reported in patients. This study aimed to explore changes in the plasma metabolome during the active and remission phases of PACNS and identify potential biomarkers.
Methods: We collected plasma samples from 35 patients with PACNS during the active and remission phases and 22 samples from patients with non-inflammatory disease as controls.
Purpose: To evaluate the two-year outcomes of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL), and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract.
Design: Multicenter prospective study.
Methods: The study included patients who received a combined SPI + GSL + GT for advanced PACG without cataract, all completed a 24-month follow-up.
Background: To develop a predictive model using baseline imaging of morphology and radiomics derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) to determine the pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) in breast cancer patients.
Methods: A total of 265 patients who underwent 3.0 T MRI scans before NACT were examined.
Microorganisms
February 2025
Alternative splicing plays a crucial role in enhancing the protein diversity of eukaryotic genomes. However, alternative splicing has not been extensively studied in . In this study, we examined the distribution and regulation of alternative splicing in the filamentous plant pathogenic fungus through strand-specific RNA sequencing at various stages of infection of .
View Article and Find Full Text PDFGeSn is a group-IV alloy with immense potential to advance microelectronics technology due to its intrinsic compatibility with existing Si CMOS processes. With a sufficiently high Sn composition, GeSn is classified as a direct bandgap semiconductor. Polycrystalline GeSn holds several additional advantages, including its significantly lower synthesis cost compared to its epitaxial counterpart, as well as the versatility to grow these films on a variety of substrates.
View Article and Find Full Text PDFComput Biol Chem
April 2025
Drug-drug interactions (DDIs) occur when multiple medications are co-administered, potentially leading to adverse effects and compromising patient safety. However, existing DDI prediction methods often overlook the intricate interactions among chemical substructures within drugs, resulting in incomplete characterization of molecular properties. To address this limitation, we propose a novel model named Multi-Layer Soft Mask Dual-View Learning for Drug-Drug Interactions (MSMDL-DDI), which integrates dual-view learning with multi-layer soft mask graph neural networks to comprehensively capture intra- and inter-molecular interactions.
View Article and Find Full Text PDFObjective: The use of anticoagulants to prevent deep vein thrombosis (DVT) after intracerebral hemorrhage (ICH) remains controversial. This study aims to evaluate the safety of anticoagulants in preventing DVT in patients with ICH.
Methods: Data were sourced from the Chinese Stroke Center Alliance.
This phase III trial aimed to compare ARX788, a site-specific, construct-homogeneous antibody-drug conjugate, with lapatinib plus capecitabine in patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer (ABC) who had progressed on one line of trastuzumab based regimen. Eligible patients were randomized (1:1) to receive ARX788 (1.5 mg/kg, IV, Q3W) or lapatinib plus capecitabine (LC: lapatinib 1250 mg QD; capecitabine 1000 mg/m BID, days 1-14, Q3W) and stratified by prior chemotherapy lines (0-1 versus >1) and visceral metastasis (yes versus no).
View Article and Find Full Text PDFVegetation is a core component of terrestrial ecosystems, thus understanding the drivers of its dynamics is crucial for ecological conservation and management, especially in regions rich in natural resources but ecologically fragile. Here, we examined vegetation cover changes in China's western frontiers and quantified the relative importance of key drivers of vegetation dynamics. First, we employed the Dimidiate Pixel Model (DPM) via Google Earth Engine (GEE) to estimate fractional vegetation cover (FVC), followed by trend analysis using the Theil-Sen median and Mann-Kendall methods to examine FVC dynamics from 2010 to 2021.
View Article and Find Full Text PDFBackground: Pre-implantation genetic testing (PGT) is served as the primary technology for diagnosing genetic disorders. However, invasive operation may affect embryonic development, which indicates non-invasive methods might have important clinical value. Free DNA in blastocoele fluid provides the possibility for non-invasive diagnosis.
View Article and Find Full Text PDFStent implantation effectively relieves coronary artery disease (CAD), and post-surgery cardiac rehabilitation is essential for prognosis. This study aimed to investigate the knowledge, attitude, and practice (KAP) of patients undergoing coronary artery stenting regarding cardiac rehabilitation. Conducted in multiple hospitals from December 2023 to January 2024, a self-administered questionnaire collected demographic information and KAP scores.
View Article and Find Full Text PDFOrganic light-emitting materials with multi-resonance thermally activated delayed fluorescence (MR-TADF) have shown great potential for realizing highly efficient narrowband organic light-emitting diodes (OLEDs). However, the heavy efficiency roll-off caused by the slow reverse intersystem crossing (RISC) process remains a challenging issue for the further practical application of MR-TADF materials. Here, we develop two TADF emitters, BNDBT and BNDBF, in which the dibenzothiophene and dibenzofuran substituents are attached at the bottom of the B/N frameworks.
View Article and Find Full Text PDFBMC Med Inform Decis Mak
February 2025
Background: Agent negotiation is widely used in e-commerce negotiation, cloud service service-level agreements, and power transactions. However, few studies have adapted alternative negotiation models to negotiation processes between healthcare professionals and patients due to the fuzziness, ethics, and importance of medical decision making.
Method: We propose a Bayesian learning based bilateral fuzzy constraint agent negotiation model (BLFCAN).
Objective: Conventional imaging often struggles to differentiate between primary angiitis of the central nervous system (PACNS) and intracranial tumors. This study aims to evaluate the application value of proton magnetic resonance spectroscopy (H-MRS) in distinguishing PACNS from intracranial tumors.
Methods: This study collected data from 10 patients with PACNS and 15 patients with intracranial tumors (10 gliomas and 5 lymphomas) confirmed by pathological biopsy.
Objective: To evaluated the predictive value of several cerebrospinal fluid (CSF) cytokines in the conversion of clinically isolated syndrome (CIS) patients to neuromyelitis optica spectrum disorder (NMOSD) or multiple sclerosis (MS).
Methods: We enrolled 33 CIS patients whose CSF samples were collected during the acute phase of the first onset before immunotherapy. The CSF levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IL-13, IL-17A, IL-21, IL-23, interferon-γ (IFN-γ) and transforming growth factor beta 1 (TGF-β1) were measured using the human cytokine multiplex assay or ELISA.
Expert Opin Drug Saf
March 2025
Background: Selinexor is approved for the treatment of relapsed or refractory multiple myeloma. However, a comprehensive understanding of adverse events associated with selinexor is lacking.
Methods: Clinical trials of selinexor in patients with multiple myeloma were reviewed.
Two-point contact is one of the fundamental problems of wheel-rail contact in switch area. The contact state and the distribution of forces are complex and essential points in wheel-rail relationship. Given the problem that the current dynamic wheel-rail contact state is challenging to detect, a theory to detect the two-point contact state of the wheel-rail in switch area using a discrete gauge column was presented and proved in the finite element model.
View Article and Find Full Text PDFZoonoses are infectious diseases transmitted from animals to humans. Bats have been suggested to harbour more zoonotic viruses than any other mammalian order. Infections in bats are largely asymptomatic, indicating limited tissue-damaging inflammation and immunopathology.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) relies heavily on glutamine (Gln) utilization to meet its metabolic and biosynthetic needs. How epigenetic regulators contribute to the metabolic flexibility and PDAC's response and adaptation to Gln scarcity in the tumor milieu remains largely unknown. Here, we elucidate that prolonged Gln restriction or treatment with the Gln antagonist, 6-diazo-5-oxo-L-norleucine (DON), leads to growth inhibition and ferroptosis program activation in PDAC.
View Article and Find Full Text PDFLithium (Li) metal's extremely high specific energy and low potential make it critical for high-performance batteries. However, uncontrolled dendrite growth and an unstable solid-electrolyte interphase (SEI) during repeated cycling still seriously hinder its practical application in Li metal batteries. Herein, we demonstrate a facile and effective approach to fabricate a flexible and robust hybrid SEI layer using two kinds of organo-polysulfides with different sulfur chain lengths [bis(3-(triethoxysilyl)propyl)disulfide (Si-O-2S) and bis(3-(triethoxysilyl)propyl)tetrasulfide (Si-O-4S)] as the additives in the electrolyte.
View Article and Find Full Text PDFThe default-interventionist model of dual-process theories proposes that stereotype descriptions in base-rate problems are processed using Type 1 processing, while the evaluation of base rates depends on Type 2 processing. The logical intuition view posits that people can process base-rate information using Type 1 processing. This study examined the logical intuition view using the instructional manipulation paradigm.
View Article and Find Full Text PDFTwo-dimensional (2D) transition metal dichalcogenides (TMDs), such as WSe, are promising candidates for next-generation integrated circuits. However, the dependence of intrinsic properties of TMD devices on various processing steps remains largely unexplored. Here, using pristine p-type WSe devices as references, we comprehensively studied the influence of each step in traditional nanofabrication methods on device performance.
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