Decision-Making for Ablation of Colorectal Liver Oligometastases Patients: A 10-Year Retrospective Study of Survival Outcomes Based on Right-Versus Left-Sided Primary Tumor Location.

ObjectiveTo develop a prognostic model for optimizing management of colorectal liver oligometastases (CLOM) patients with different primary tumor locations who underwent thermal ablation (TA).Materials and MethodsThe reporting of this retrospective study conforms to STROBE guidelines. A total of 525 CLOM patients who underwent TA from 3 hospitals between 2011 and 2021 were enrolled.

Circulating Immune Features Synergizing Neutrophil-to-Lymphocyte Ratio in Prediction of Poor Survival of Early-Stage Hepatocellular Carcinoma After Thermal Ablation.

Background and AimPredictors of neutrophil-to-lymphocyte ratio (NLR) and traditional clinical variables for hepatocellular carcinoma (HCC) prognosis after locoregional therapies were useful while exhibited modest prognostic performances. We dig out the potential of circulating immune features for HCC prognosis prediction.Methods244 patients with early-stage HCC who were treated with thermal ablation and performed the peripheral blood mononuclear cells (PBMCs) tests were included.

Development and validation of an ultrasound-based interpretable machine learning model for the classification of ≤3 cm hepatocellular carcinoma: a multicentre retrospective diagnostic study.

Background: Our study aimed to develop a machine learning (ML) model utilizing grayscale ultrasound (US) to distinguish ≤3 cm small hepatocellular carcinoma (sHCC) from non-HCC lesions.

Methods: A total of 1052 patients with 1058 liver lesions ≤3 cm from 55 hospitals were collected between May 2017 and June 2021, and 756 liver lesions were randomly allocated into train and internal validation cohorts at a 8:2 ratio for the development and evaluation of ML models based on multilayer perceptron (MLP) and extreme gradient boosting (XGBoost) methods (Model utilizing US imaging features; Model adding US radiomics features; Model employing clinical features further). The diagnostic performance of three models was assessed in external validation cohort (312 liver lesions from 14 hospitals).

A deep learning based ultrasound diagnostic tool driven by 3D visualization of thyroid nodules.

Recognizing the limitations of computer-assisted tools for thyroid nodule diagnosis using static ultrasound images, this study developed a diagnostic tool utilizing dynamic ultrasound video, namely Thyroid Nodules Visualization (TNVis), by leveraging a two-stage deep learning framework that involved three-dimensional (3D) visualization. In this multicenter study, 4569 cases were included for framework development, and data from seven hospitals were employed for diagnostic validation. TNVis achieved a Dice similarity coefficient of 0.

Integration of single-cell and spatial transcriptomics reveals fibroblast subtypes in hepatocellular carcinoma: spatial distribution, differentiation trajectories, and therapeutic potential.

Background: Cancer-associated fibroblasts (CAFs) are key components of the hepatocellular carcinoma (HCC) tumor microenvironment (TME). regulating tumor proliferation, metastasis, therapy resistance, immune evasion via diverse mechanisms. A deeper understanding of the l diversity of CAFs is essential for predicting patient prognosis and guiding treatment strategies.

[Effects of dietary fiber from cassava on food glycemic index].

Objective: To detect the glycemic index(GI) of liquid dietary fiber from cassava and mixed foods made of milk powder and flour, and to study the effect of liquid dietary fiber on food GI.

Methods: A total of 12 healthy adult volunteers, half male and half female, were selected to eat 6 kinds of food at different times, including glucose powder containing 50 grams of available carbohydrate, liquid dietary fiber, milk powder, bread and milk powder and bread with 20% liquid dietary fiber added. For each food, blood glucose was measured before eating and at 15, 30, 45, 60, 90 and 120 minutes after eating.

Achieving Room-Temperature Phosphorescence in Solution Phase from Carbon Dots Confined in Nanocrystals.

Carbon dots (CDs) have attracted growing interest in the construction of room-temperature phosphorescent (RTP) materials. However, in the solution phase of CDs, it is still challenging to obtain efficient and stable phosphorescent emission due to the intense quenching effect by dissolved oxygen and solvent molecules. Herein, we report robust phosphorescence in the solution phase, achieved by encapsulating citrate-derived CDs into NaYF nanocrystals via a one-step method of high-temperature coprecipitation.

Age-stratified deep learning model for thyroid tumor classification: a multicenter diagnostic study.

Objectives: Thyroid cancer, the only cancer that uses age as a specific predictor of survival, is increasing in incidence, yet it has a low mortality rate, which can lead to overdiagnosis and overtreatment. We developed an age-stratified deep learning (DL) model (hereafter, ASMCNet) for classifying thyroid nodules and aimed to investigate the effect of age stratification on the accuracy of a DL model, exploring how ASMCNet can help radiologists improve diagnostic performance and avoid unnecessary biopsies.

Methods: In this retrospective study, we used ultrasound images from three hospitals, a total of 10,391 images of 5934 patients were used for training, validation, and testing.

Foundational insights for theranostic applications of magnetoelectric nanoparticles.

Reviewing emerging biomedical applications of MagnetoElectric NanoParticles (MENPs), this paper presents basic physics considerations to help understand the possibility of future theranostic applications. Currently emerging applications include wireless non-surgical neural modulation and recording, functional brain mapping, high-specificity cell electroporation for targeted cancer therapies, targeted drug delivery, early screening and diagnostics, and others. Using an analysis, each application is discussed from the perspective of its fundamental limitations.

The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma.

Background: PTC (papillary thyroid cancer) is a lymphotropic malignancy associated with cervical lymph node metastasis (CLNM, including central and lateral LNM), which compromises the effect of treatment and prognosis of patients. Accurate preoperative identification will provide valuable reference information for the formulation of diagnostic and treatment strategies. The aim of this study was to develop and validate a clinical-multimodal ultrasound radiomics model for predicting CLNM of PTC.

Multimodal cross-scale context clusters for classification of mental disorders using functional and structural MRI.

The brain is a complex system with multiple scales and hierarchies, making it challenging to identify abnormalities in individuals with mental disorders. The dynamic segregation and integration of activities across brain regions enable flexible switching between local and global information processing modes. Modeling these scale dynamics within and between brain regions can uncover hidden correlates of brain structure and function in mental disorders.

The use of large language models in detecting Chinese ultrasound report errors.

This retrospective study evaluated the efficacy of large language models (LLMs) in improving the accuracy of Chinese ultrasound reports. Data from three hospitals (January-April 2024) including 400 reports with 243 errors across six categories were analyzed. Three GPT versions and Claude 3.

Contrast-enhanced ultrasound-based AI model for multi-classification of focal liver lesions.

Background & Aims: Accurate multi-classification is the prerequisite for reasonable management of focal liver lesions (FLLs). Ultrasound is the common image examination, but lacks accuracy. Contrast enhanced ultrasound (CEUS) offers better performance, but highly relies on experience.

Analysis of factors influencing the awareness of inpatients regarding hospital clinical pharmacy services and willingness to pay: a multicenter survey in Hebei Province, China.

Introduction: Pharmacists are increasingly adopting patient-centered roles, improving healthcare outcomes by reducing medication errors and costs. In China, recent healthcare reforms recognize and compensate for pharmacy services. However, patient awareness of these services and their willingness to pay (WTP) remain underexplored.

LMNA-related cardiomyopathy: From molecular pathology to cardiac gene therapy.

Background: The genetic variants of LMNA cause an array of diseases that often affect the heart. LMNA-related cardiomyopathy exhibits high-penetrance and early-onset phenotypes that lead to late-stage heart failure or lethal arrhythmia. As a subtype of dilated cardiomyopathy and arrhythmogenic cardiomyopathy, LMNA-related cardiac dysfunction is resistant to existing cardiac therapeutic strategies, leaving a major unmet clinical need in cardiomyopathy management.

Preparation and photoelectric properties of Si:B nanowires with thermal evaporation method.

We have successfully prepared a significant number of nanowires from non-toxic silicon sources. Compared to the SiO silicon source used in most other articles, our preparation method is much safer. It provides a simple and harmless new preparation method for the preparation of silicon nanowires.

Determination of osimertinib concentration in rat plasma and lung/brain tissues.

Objectives: The aim of this study was to establish an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the detection of osimertinib in rat plasma, lung and brain tissues.

Methods: Forty-eight rats were randomly divided into an experimental group (receiving osimertinib at doses of 5, 8, and 10 mg/kg) and a control group. After continuous intragastric administration for 15 days, samples of blood, lung, and brain tissue were collected.

A fuzzy reliability assessment methodology for city gas stations based on an extended T-S fault tree.

City gas stations (CGSs) play a crucial role in ensuring a stable and safe supply of natural gas to urban users. However, as the service time of stations increases and the performance of components deteriorates, concerns about the safety and reliability of these station have grown among operators and local government authorities. This paper proposes a fuzzy reliability assessment methodology for CGSs that considers the polymorphism of component faults and the uncertainties associated with fault relationships, failure probabilities, and fault magnitudes.

The ability of contrast-enhanced ultrasound with Sonazoid to differentiate endometrial carcinoma from benign endometrial lesions: A preliminary, prospective, and multicenter clinical study.

Objective: To examine the diagnostic efficacy of contrast-enhanced ultrasound (CEUS) with Sonazoid (Sonazoid-CEUS) for endometrial lesions.

Methods: In this prospective and multicenter study, data were collected from 84 patients with endometrial lesions from 11 hospitals in China. All the patients received a conventional US and Sonazoid-CEUS examination.

Dissolution, solvation and diffusion in low-temperature zinc electrolyte design.

Aqueous zinc-based batteries have garnered the attention of the electrochemical energy storage community, but they suffer from electrolytes freezing and sluggish kinetics in cold environments. In this Review, we discuss the key parameters necessary for designing anti-freezing aqueous zinc electrolytes. We start with the fundamentals related to different zinc salts and their dissolution and solvation behaviours, by highlighting the effects of anions and additives on salt solubility, ion diffusion and freezing points.

US-Guided Thermal Ablation for Secondary Hyperparathyroidism: A Prospective Multicenter Study.

Background Interest in microwave ablation (MWA) and radiofrequency ablation (RFA) use for treating secondary hyperparathyroidism (SHPT) is rising; however, ablation outcomes in patients with SHPT are not well characterized. Purpose To assess the response of parathyroid hormone (PTH), calcium, phosphorus, and alkaline phosphatase (ALP) levels to US-guided parathyroid MWA and RFA and the safety of these treatments in participants with SHPT. Materials and Methods This prospective multicenter cohort study, conducted from September 2017 to March 2022, included participants with SHPT.

Effects of Cover Crops on Nematode Communities in Spinach Production.

Agricultural soil environments contain different types of nematodes in all trophic levels that aid in balancing the soil food web. Beneficial free-living nematodes (FLNs) consist of bacterivores, fungivores, predators, and omnivores that help in the mineralization of the soil and the top-down control of harmful plant-parasitic nematodes (PPNs). Annually, USD 125 billion in worldwide crop losses are caused by PPNs, making them a plant pathogen of great concern for growers.

Chinese guidelines for ultrasound-guided thermal ablation of thyroid nodules (2024 edition).

The Chinese guidelines for ultrasound-guided thermal ablation of thyroid nodules (2024 edition) were jointly initiated by the Ultrasound Committee of Chinese Medical Association, the Interventional Ultrasound Committee of Chinese Association of Ultrasound in Medicine and Engineering, the Ultrasonic Intervention Committee of Chinese Colleges of Interventionalists, and the Oncological Intervention Committee of Chinese Research Hospital Association; 37 multidisciplinary experts in interventional ultrasound, ultrasound medicine, endocrinology, and thyroid surgery participated in the compilation of this guide, which expanded the depth and breadth of the perspective and enhanced the authority of the guide. Based on the systematic review of literature related to ultrasound-guided thermal ablation of thyroid nodules and the professional opinions of experts, the guidelines define the indications and contraindications of thermal ablation, including pre-ablation evaluation and preparation, thermal ablation techniques and operational procedures, post-ablation follow-up, therapeutic effect evaluation, complication prevention and treatment, and the writing of medical documents for ablation. According to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE), a total of 17 objective and comprehensive recommendations were given.

Chinese expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition).

Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options are lacking, resulting in a poor prognosis. Over the past few years, the combination of immune checkpoint inhibitors and anti-angiogenic targeted therapy has proven highly efficacious in treating advanced HCC, significantly extending patients' survival and providing a potential for sequential curative surgery. After sequential curative hepatectomy or liver transplantation following conversion therapy, patients can receive long-term survival benefits.

Laparoscopic hepatectomy versus microwave ablation for multifocal 3-5 cm hepatocellular carcinoma: a multi-centre, real-world study.

Background: Researches comparing laparoscopic liver resection (LLR) with microwave ablation (MWA) for 3-5 cm multifocal hepatocellular carcinoma (MFHCC) are rare.

Materials And Methods: From 2008 to 2019, 666 intrahepatic tumours in 289 patients from 12 tertiary medical centres in China were included in this retrospective study. Propensity score matching (PSM) was performed to balance variables between the two treatment groups over time frames 2008-2019 and 2013-2019 to observe the potential impact of advancements in intervention techniques on overall survival (OS), disease-free progression (DFS) of patients.