Baolier Capsule's Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis.

Purpose: The Baolier capsule (BLEC) is a proprietary Mongolian medicine administered for treating hypercholesterolemia and atherosclerosis (AS). However, the therapeutic effects, primary bioactive ingredients, and potential mechanisms underlying hypercholesterolemia and AS remain unclear. This study aimed to investigate the pharmacological effects, principal active ingredients, and mechanisms of BLEC against hypercholesterolemia and AS.

Negative feedback between PTH1R and IGF1 through the Hedgehog pathway in mediating craniofacial bone remodeling.

Regeneration of orofacial bone defects caused by inflammatory-related diseases or trauma remains an unmet challenge. Parathyroid hormone 1 receptor (PTH1R) signaling is a key mediator of bone remodeling whereas the regulatory mechanisms of PTH1R signaling in oral bone under homeostatic or inflammatory conditions have not been demonstrated by direct genetic evidence. Here we observed that deletion of PTH1R in Gli1+-progenitors led to increased osteogenesis and osteoclastogenesis.

Investigation of 3D Printed Self-Sensing UHPC Composites Using Graphite and Hybrid Carbon Microfibers.

This paper explores the development of 3D-printed self-sensing Ultra-High Performance Concrete (UHPC) by incorporating graphite (G) powder, milled carbon microfiber (MCMF), and chopped carbon microfiber (CCMF) as additives into the UHPC matrix to enhance piezoresistive properties while maintaining workability for 3D printing. Percolation curves were established to identify optimal filler inclusion levels, and a series of compressive tests, including quasi-static cyclic, dynamic cyclic, and monotonic compressive loading, were conducted to evaluate the piezoresistive and mechanical performance of 29 different mix designs. It was found that incorporating G powder improved the conductivity of the UHPC but decreased compressive strength for both mold-cast and 3D-printed specimens.

Integrated transcriptomic and proteomic analyses reveal the effects of chronic benzene exposure on the central nervous system in mice.

Benzene exposure is known to cause serious damage to the human hematopoietic system. However, recent studies have found that chronic benzene exposure may also cause neurological damage, but there were few studies in this issue. The aim of this study was to investigate the mechanism of damage to the central nervous system (CNS) by chronic benzene exposure with a multi-omics analysis.

Circulating long noncoding RNA, Zfpm2-As1, and XIST based on medical data analysis are potential plasma biomarkers for gastric cancer diagnosis.

Background: Long noncoding RNAs (lncRNAs) participate in diseases, especially tumorigenesis, including gastric cancer (GC). Although lncRNAs in GC tissues have been extensively studied in previous research, the possible significance of circulating lncRNAs in diagnosing GC is still unknown.

Objective: The present work investigated lncRNAs ZFPM2-AS1 and XIST with high expression in GC tissues proved as potential plasma biomarkers from 20 early GC cases, 100 GC cases, and 90 normal subjects.

The LEPIS-HuR-TMOD4 axis regulates hepatic cholesterol homeostasis and accelerates atherosclerosis.

Background And Aims: Long noncoding RNAs (lncRNAs) play important roles in the progression of atherosclerosis. In this study, we identified an uncharacterized lncRNA, Liver Expressions by PSRC1 Induced Specifically (LEPIS). This study aimed to clarify the mechanism though which LEPIS affects atherosclerosis (AS).

The Potential Role and Therapeutic Relevance of Cellular Senescence in Skeletal Pathophysiology.

Biological aging profoundly impairs the homeostasis of the skeletal system. Cellular senescence, a hallmark of biological aging, plays an instrumental role in bone disease. The underlying mechanisms of cellular senescence, triggered by both intracellular and extracellular stimuli, are multifaceted and yet to be uncovered.

Reducing SULT2B1 promotes the interaction of LncRNAgga3-204 with SMAD4 to inhibit the macrophage inflammatory response and delay atherosclerosis progression.

Inflammation is a crucial pathophysiological mechanism in atherosclerosis (AS). This study aims to investigate the impact of sulfotransferase family 2b member 1 (SULT2B1) on the inflammatory response of macrophages and the progression of AS. Here, we reported that SULT2B1 expression increased with the progression of AS.

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy.

Hypoparathyroidism (HypoPT) is a rare disease involving the parathyroid glands that is characterized by a reduced secretion or potency of the parathyroid hormone (PTH), which leads to high serum phosphorus levels and low serum calcium levels. HypoPT most commonly results from accidental damage to the glands or their removal during thyroid or other anterior neck surgery. Parathyroid/thyroid surgery has become more common in recent years, with a corresponding rise in the occurrence of HypoPT as a postoperative complication.

Evaluation of Atlas-Based Mobile Application in Undergraduate Teaching in Oral Histopathology.

The utilization of mobile devices in education is a growing trend in various subjects. We developed the Dental and Maxillofacial Development Teaching Atlas App, and applied it to the learning process of oral histopathology. The aim of the current study was to investigate the educational effects of atlas-based mobile-assisted teaching in the field of dental medicine, and to suggest relevant improvements.

Current Applications and Future Directions of Lasers in Endodontics: A Narrative Review.

The utilization of lasers has been regarded as a novel technique for the purposes of clinical use in the dental field. Recently, numerous studies have been conducted on the potential applications of laser therapy in endodontics. Moreover, due to their ablation, penetrability, and disinfection capabilities, lasers have performed well with respect to endodontic treatments, including root canal treatment, vital pulp therapy (pulp capping and pulpotomy), dentinal hypersensitivity treatment, and management of dental pain related to pulp and periradicular disease.

A single-cell transcriptional atlas reveals resident progenitor cell niche functions in TMJ disc development and injury.

The biological characteristics of the temporomandibular joint disc involve complex cellular network in cell identity and extracellular matrix composition to modulate jaw function. The lack of a detailed characterization of the network severely limits the development of targeted therapies for temporomandibular joint-related diseases. Here we profiled single-cell transcriptomes of disc cells from mice at different postnatal stages, finding that the fibroblast population could be divided into chondrogenic and non-chondrogenic clusters.

Degradation of 1-alkyl-3-methylimidazolium tetrafluoroborate in an ultrasonic zero-valent zinc and activated carbon micro-electrolysis system.

Increased attention has been given to the removal of ionic liquids (ILs) from natural water environments. In this work, 5 kinds of 1-alkyl-3-methylimidazoliumtetrafluoroborate ([Cmim][BF] (n = 2, 4, 6, 8, 10)) ILs were degraded in an ultrasonic zero-valent zinc (ZVZ) and activated carbon (AC) micro-electrolysis system. Optimization of degradation conditions and the degradation levels were studied by high performance liquid chromatography, the surface morphology of the ZVZ and AC changed before and after the reaction were observed by scanning electron microscope.

Identification of circRNAs and circRNA-miRNA-mRNA regulatory network in radiation-induced heart disease.

Objective: Radiation-induced heart disease (RIHD) is one of the most common and serious long-term adverse effect after thoracic radiotherapy. Our aim was to investigate the potential molecular mechanism underlying RIHD using RNA-sequencing (RNA-seq) and bioinformatics methods.

Materials And Methods: An RIHD rat model was established and transcription profiles were identified using RNA-seq.

Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling.

Oral inflammatory diseases such as apical periodontitis are common bacterial infectious diseases that may affect the periapical alveolar bone tissues. A protective process occurs simultaneously with the inflammatory tissue destruction, in which mesenchymal stem cells (MSCs) play a primary role. However, a systematic and precise description of the cellular and molecular composition of the microenvironment of bone affected by inflammation is lacking.

Neural Regeneration in Regenerative Endodontic Treatment: An Overview and Current Trends.

Pulpal and periapical diseases are the most common dental diseases. The traditional treatment is root canal therapy, which achieves satisfactory therapeutic outcomes-especially for mature permanent teeth. Apexification, pulpotomy, and pulp revascularization are common techniques used for immature permanent teeth to accelerate the development of the root.

Protective Actions in Apical Periodontitis: The Regenerative Bioactivities Led by Mesenchymal Stem Cells.

Resulting from bacterial infection, apical periodontitis (AP) is a common inflammatory disease of the periapical region of the tooth. The regeneration of the destroyed periapical alveolar bone and the surrounding periodontium tissues has long been a difficult task in clinical practice. These lesions are closely related to pathogen invasion and an overreactive immune response.

Purification performance from bypass ecological treatment systems treating WWTPs effluents and improvement of water quality in receiving rivers: A case study in southern China.

Effluents from wastewater treatment plants (WWTPs) is the main source of pollution in rivers in developing countries. In this case study, three bypass ecological treatment systems along urban rivers achieved high removal efficiencies for chemical oxygen demand (COD; 55.7-64.

Composites Filled with Metal Organic Frameworks and Their Derivatives: Recent Developments in Flame Retardants.

Polymer matrix is vulnerable to fire hazards and needs to add flame retardants to enhance its performance and make its application scenarios more extensive. At this stage, it is more necessary to add multiple flame-retardant elements and build a multi-component synergistic system. Metal organic frameworks (MOFs) have been studied for nearly three decades since their introduction.

Study of Blast Mitigation Performance and Fracture Mechanism of Polyurea under Contact Explosion.

In order to further study the blast mitigation performance of polyurea and to investigate the protection mechanism and damage characteristics of polyurea-protected structures under contact explosion loads, based on earlier work, this paper investigated the response and energy absorption performance of polyurea under various frequency loads. Qtech T26 blast mitigation polyurea (T26 polyurea) was adopted to protect the reinforced concrete (RC) slab and damage analysis of the post-explosion specimens was carried out at micro and macro levels. The response and energy absorption capacity of the material towards different frequency loads were investigated by dynamic mechanical analysis (DMA).

Phthalate acid esters and polycyclic aromatic hydrocarbons concentrations with their determining factors among Chinese pregnant women: A focus on dietary patterns.

Background: Pregnant women are susceptible to adverse health effects associated with phthalate acid esters (PAEs) and polycyclic aromatic hydrocarbons (PAHs), and diet is a significant exposure source. Little is known about the contributions of dietary patterns during pregnancy to the exposure variability of these environmental contaminants.

Objectives: To identify dietary patterns in relation to PAEs and PAHs exposure in the Chinese pregnant population.

Short-Term Prognostic Efficacy of mGPS and LCS in Patients With Acute Heart Failure.

Aim: Systemic inflammation plays an important role in the occurrence and development of acute heart failure. The modified Glasgow Prognostic Score (mGPS) and "lymphocyte C-reactive protein score" (LCS) are used to assess the inflammation levels in cancer patients. The purpose of this study was to assess the prognostic value of these two inflammation-related scoring systems in patients with acute heart failure.

Polyurea for Blast and Impact Protection: A Review.

Polyurea has attracted extensive attention from researchers and engineers in the field of blast and impact protection due to its excellent quasi-static mechanical properties and dynamic mechanical properties. Its mechanical properties and energy absorption capacity have been tuned by means of formulation optimization, molecular dynamics (MD) simulation and the addition of reinforcing materials. Owing to the special molecular structure of polyurea, the mechanism of polyurea protection against blasts and impacts is the simultaneous effect of multiple properties.

Monitoring and control methods of harmful algal blooms in Chinese freshwater system: a review.

Harmful algal blooms (HABs) are a worldwide problem with substantial adverse effects on the aquatic environment as well as human health, which have prompted researchers to study measures to stem and control them. Meanwhile, it is key to research and develop monitoring methods to establish early warning HABs. However, both the current monitoring methods and control methods have some shortcomings, making the field application limited.

Changes in Laminin in Acute Heart Failure.

Laminin is a major component of the basement membrane of cardiomyocytes and has been found at a high level in patients with heart failure. However, detailed information on the relationship between disease management and progression in patients with acute heart failure (AHF) remains lacking. We focused on the levels of laminin (LN) before and after admission to the hospital in AHF patients.