Parasympathetic Airway Hyperreactivity Is Enhanced in Acute but Not Chronic Eosinophilic Asthma Mouse Models.

Airway hyperreactivity in asthma is mediated by airway nerves, including sensory nerves in airway epithelium and parasympathetic nerves innervating airway smooth muscle. Isolating the function of these two nerve populations in vivo, to distinguish how each is affected by inflammatory processes and contributes to hyperreactivity in asthma, has been challenging. In this study, we used optogenetic acti-vation of airway nerves in vivo to study parasympathetic contributions to airway hyperreactivity in two mouse models of asthma: 1) acute challenge with house dust mite antigen, and 2) chronic airway hy-pereosinophilia due to genetic IL-5 overexpression in airways.

Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation.

The appearance of misfolded and aggregated proteins is a pathological hallmark of numerous neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Sleep disruption is proposed to contribute to these pathological processes and is a common early feature among neurodegenerative disorders. Synucleinopathies are a subclass of neurodegenerative conditions defined by the presence of α-synuclein aggregates, which may not only enhance cell death, but also contribute to disease progression by seeding the formation of additional aggregates in neighboring cells.

Affective Sensitivity to Air Pollution (ASAP): Person-specific associations between daily air pollution and affective states.

Individuals' sensitivity to climate hazards is a central component of their vulnerability to climate change. In this paper, we introduce and outline the utility of a new intraindividual variability construct, affective sensitivity to air pollution (ASAP)-defined as the extent to which an individual's affective states fluctuate in accordance with daily changes in air quality. As such, ASAP pushes beyond examination of differences in individuals' exposures to air pollution to examination of differences in individuals' sensitivities to air pollution.

A Multi-Method Study of Interpersonal Complementarity and Mentalization.

Research finds cross-sectional relationships between mentalizing impairments and maladaptive personality traits. The current study connects mentalizing impairments to dynamic interpersonal processes using a multi-method design. A sample of 218 participants completed the Movie for the Assessment of Social Cognition (MASC; Dziobek et al.

Interpersonal Problem Profiles of Personality and Psychopathology Constructs in Chinese Undergraduates and Offenders.

The interpersonal problem circumplex is extensively used in the field as an assessment framework for understanding the interpersonal implications of a range of personality and psychopathology constructs. The vast majority of this large literature has been conducted in Western convenience and clinical samples. We computed interpersonal problem structural summary parameters for a range of personality and psychopathology variables in two Chinese offender samples ( = 424 and = 555) and one undergraduate sample ( = 511) to test how well findings from Western samples generalize to Chinese undergraduates and offenders.

Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second-generation offspring.

Asthma susceptibility is influenced by environmental, genetic, and epigenetic factors. DNA methylation is one form of epigenetic modification that regulates gene expression and is both inherited and modified by environmental exposures throughout life. Prenatal development is a particularly vulnerable time period during which exposure to maternal asthma increases asthma risk in offspring.

On definition and description in psychopathology: Reply to Widiger et al. (2023).

We reply to Wright et al.'s (2023) commentary and suggestion that personality trait models would be the preferred way to reconfigure the personality disorders (PDs). Though we agree that personality trait models are powerful descriptive tools, we highlight that they lack definitional or explanatory power, and that is why they have not been able to define or distinguish what PDs are (Hopwood, 2018; Mõttus et al.

Age and gender differences in narcissism: A comprehensive study across eight measures and over 250,000 participants.

Age and gender differences in narcissism have been studied often. However, considering the rich history of narcissism research accompanied by its diverging conceptualizations, little is known about age and gender differences across various narcissism measures. The present study investigated age and gender differences and their interactions across eight widely used narcissism instruments (i.

Contemporary integrative interpersonal theory: Integrating structure, dynamics, temporal scale, and levels of analysis.

Theoretical accounts of psychopathology often emphasize social context as etiologically central to psychological dysfunction, and interpersonal impairments are widely implicated for many legacy diagnostic categories that span domains of psychopathology (e.g., affective, personality, thought disorders).

Interpersonal Complementarity and Affect in Daily Life.

The current study examines the associations between interpersonal complementarity and affective reactions during social interactions in daily life, as well as contextual moderators of these associations. This research aims to understand how satisfaction/frustration of interpersonal motives (operationalized as interpersonal complementarity) impacts affect, using Contemporary Integrative Interpersonal Theory as a guiding framework. Participants ( = 227) rated actor and partner agency and communion in interpersonal interactions in 6 prompted surveys per day for 21 days.

Validation of the pathological narcissistic inventory (PNI) and its brief form (B-PNI) in the Arabic language.

Background: The Pathological Narcissism Inventory (PNI) is a multidimensional measure developed to assess narcissistic grandiosity and narcissistic vulnerability. We aimed to validate the Arabic version of the original Pathological Narcissistic Inventory (PNI) and its brief form (B-PNI) in a community sample of Lebanese adults.

Methods: The English language PNI items were translated into Arabic following a rigorous translation, back-translation, and linguistic evaluation.

Psychometric evaluation of a Visual Interpersonal Analog Scale.

Interpersonal theory organizes social behavior along dominant (vs. submissive) and warm (vs. cold) dimensions.

Examining Schizotypal Personality Scales Within and Across Interpersonal Circumplex Surfaces.

Differing perspectives on the operationalization of schizotypal personality pathology (STPP) have led to numerous multidimensional assessment measures. The current study applied the interpersonal construct validation approach to self-report data from 856 undergraduate students to formally examine the interpersonal content, similarities, and differences in the subscales of four measures of STPP within and across two interpersonal circumplex surfaces using a bootstrapping methodology for computing confidence intervals around circumplex structural summary method parameters. Results suggested that negative-like expressions of STPP are prototypically and distinctively interpersonal constructs associated with cold and socially avoidant interpersonal problems and hypersensitivity to others' warmth and affection.

It's time to replace the personality disorders with the interpersonal disorders.

Personality disorders (PDs) are among the most common and severe classes of psychopathology. From a clinical perspective, it is challenging to help individuals with personality disorders because treatment ruptures, discontinuation, reversals, and failures are relatively common. An additional clinical challenge is that the model used to diagnose personality disorders is demonstrably incorrect.

Examining the Influence of Gender, Child Abuse, and Narcissism on Four Forms of Interpersonal Violence Among Men and Women College Students.

This study examines the moderating effects of gender, child abuse, and pathological narcissism on self-reported stalking, sexual harassment, intimate partner violence, and sexual aggression in undergraduate men and women. Child abuse was positively associated with engaging in all forms of interpersonal violence for both genders. For women, pathological narcissism moderated this association such that higher levels of pathological narcissism reduced the association between child abuse and engaging in stalking, sexual harassment, sexual aggression.

Unique Allergic Asthma Phenotypes in Offspring of House Dust Mite-exposed Mice.

Asthma is a heterogeneous inflammatory airway disease that develops in response to a combination of genetic predisposition and environmental exposures. Patients with asthma are grouped into phenotypes with shared clinical features and biomarker profiles to help tailor specific therapies. However, factors driving development of specific phenotypes are poorly understood.

Multicolor labeling of airway neurons and analysis of parasympathetic heterogeneity.

We report subpopulations of airway parasympathetic neurons expressing substance P, neuronal nitric oxide synthase, and tyrosine hydroxylase, highlighting unexplored heterogeneity in this population. These neurotransmitter-specific subpopulations did not form intraganglionic interneurons, but rather, extended outside the ganglia, into the airways, to distant innervation targets. Our experiments demonstrate the utility of multicolor labeling to characterize airway innervation, allowing us to confirm the extensive heterogeneity of postganglionic parasympathetic neurons.

Trading Patients: Applying the Alternative Model for Personality Disorders to Two Cases of Borderline Personality Disorder Over Time and Across Therapists.

The - Alternative Model for Personality Disorders (AMPD) dimensionally defines personality pathology using severity of dysfunction and maladaptive style. As the empirical literature on the clinical utility of the AMPD grows, there is a need to examine changes in diagnostic profiles and personality expression in treatment over time. Assessing these changes in individuals diagnosed with borderline personality disorder (BPD) is complicated by the tendency for patients to cycle through multiple therapists over the course of treatment leaving the potential for muddled diagnostic clarity and disjointed case conceptualizations.

Five-factor model trait profiles of narcissistic grandiosity and narcissistic vulnerability in Iranian university students.

This study examined the relationship between pathological narcissism, narcissistic grandiosity, narcissistic vulnerability and the five-factor model of personality. Participants consisted of 290 undergraduate students from four universities in three different cities in Iran, recruited by available sampling, Instruments, including, Pathological Narcissism Inventory (PNI) and the NEO Five-Factor Inventory (NEO-FFI) were also completed for the participants. Hierarchical regression analysis showed that narcissistic grandiosity was positively associated with extraversion and openness, while narcissistic vulnerability and overall pathological narcissism were positively associated with neuroticism and negatively related to agreeableness and openness (only for narcissistic vulnerability).

My problem or yours? Interpersonal problems and marital quality.

Objective: Research has consistently illustrated the impact of personality on marital quality. Given the inherent dyadic nature of relationships, recent investigations have integrated spouse-rated personality to account for both spouses' perspectives. Grounded in Contemporary Integrative Interpersonal Theory, we viewed personality through an interpersonal lens and conceptualized maladaptive interpersonal functioning as interpersonal problems.

Comparing English-Language and Chinese-Language Assessment of Personality Disorders and Interpersonal Problems in Chinese Bilingual Speakers.

A review of the literature on Chinese translations of Western self-report personality disorder assessment measures indicates the need to empirically evaluate the validity of assessing Western personality disorder constructs in Chinese language and culture. The current study presents a novel approach to examining this critical question in cross-cultural clinical assessment science and practice. One hundred and ninety-nine (199) Mandarin Chinese and English bilingual participants (92 males and 107 females) provided both English and Chinese self-report ratings on the Inventory of Interpersonal Problems - Short Circumplex (IIP-SC) and The Personality Diagnostic Questionnaire - 4+ (PDQ-4+).

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Shortcomings of approaches to classifying psychopathology based on expert consensus have given rise to contemporary efforts to classify psychopathology quantitatively. In this paper, we review progress in achieving a quantitative and empirical classification of psychopathology. A substantial empirical literature indicates that psychopathology is generally more dimensional than categorical.

Examining the Structure and Validity of Self-Report Measures of Alternative Model for Personality Disorders Criterion A.

The Level of Personality Functioning Scale (LPFS) operationalizes Criterion A of the Alternative Model for Personality Disorders. Despite progress in LPFS measurement development and validation, there is a lack of research, and some disagreement, concerning structural, convergent, and incremental validity of LPFS self-report measures. The present study aimed to compare the LPFS Self-Report, LPFS Self-Report of Criterion A, and LPFS Brief Form.

Six assumptions of contemporary integrative interpersonal theory of personality and psychopathology.

Contemporary integrative interpersonal theory is an evidence-based model of personality, psychopathology, and intervention. In this article, we review six assumptions of contemporary integrative interpersonal theory that distinguish it from other frameworks and suggest five particularly promising and important areas for future research.