Publications by authors named "Pinchefsky E"
Objective: We investigated how electroencephalography (EEG) quantitative measures and dysglycemia relate to neurodevelopmental outcomes following neonatal encephalopathy (NE).
Methods: This retrospective study included 90 neonates with encephalopathy who received therapeutic hypothermia. EEG absolute spectral power was calculated during post-rewarming and 2-month follow-up.
Article Synopsis
- This text is a correction for a previously published article with the DOI: 10.3389/fnhum.2021.675154.
- It addresses errors or inaccuracies found in the original publication.
- The correction aims to clarify or update information that may affect the conclusions drawn in the study.
Introduction: Preschoolers and school-aged children with congenital heart disease (CHD) are at higher risk of attention deficit hyperactivity disorder (ADHD) compared with the general population. To this day, no randomised controlled trial (RCT) aiming to improve attention has been conducted in young children with CHD. There is emerging evidence indicating that parent-child yoga interventions improve attention and reduce ADHD symptoms in both typically developing and clinical populations.
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- MOGAD is a newly identified neuroinflammatory disease characterized by the presence of anti-MOG antibodies, with symptoms varying widely among patients.
- A study conducted in Quebec found a prevalence of 0.52 cases per 100,000 people, with optic neuritis and acute disseminated encephalomyelitis being the most common initial symptoms.
- Only 38% of patients fully recovered within 4 weeks, and a significant number of patients experienced relapses and residual deficits, indicating a serious disease course for many.*
Article Synopsis
- Therapeutic hypothermia (TH) is now a standard treatment for neonates with moderate to severe neonatal encephalopathy (NE), helping reduce mortality and severe disabilities, but children often face cognitive and behavioral challenges as they grow.
- A major study will track the developmental outcomes of these children at 9 years old, focusing on comparing their cognitive and emotional skills against peers without NE, while also exploring brain structures and possible influencing factors.
- The research is ethically approved and funded by the Canadian Institute of Health Research, with plans to publish results and share findings with healthcare providers and parental associations to improve care practices.
Background And Objectives: Seizures are common during neonatal encephalopathy (NE), but the contribution of seizure burden (SB) to outcomes remains controversial. This study aims to examine the relationship between electrographic SB and neurologic outcomes after NE.
Methods: This prospective cohort study recruited newborns ≥36 weeks postmenstrual age around 6 hours of life between August 2014 and November 2019 from a neonatal intensive care unit (NICU).
The term Pontocerebellar Hypoplasia (PCH) was initially used to designate a heterogeneous group of fetal-onset genetic neurodegenerative disorders. As a descriptive term, PCH refers to pons and cerebellum of reduced volume. In addition to the classic PCH types described in OMIM, many other disorders can result in a similar imaging appearance.
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- Infants born to diabetic mothers (IDM) are more likely to experience complications and poor short-term outcomes after hypoxic-ischemic encephalopathy (HIE) compared to those born to non-diabetic mothers.
- A study involving 102 term neonates with HIE showed that those exposed to maternal diabetes had lower gestational ages, higher birth weights, and required longer ventilation and NICU stays.
- Maternal diabetes increased the risk of adverse outcomes, including a higher likelihood of death or abnormal neurological findings at discharge, highlighting the need for better diabetes management during pregnancy.
Article Synopsis
- Infantile epileptic spasm syndrome (IESS) is a serious condition in infants linked to developmental regression, and this study explores how heart rate variability (HRV) could indicate the onset of IESS.
- Sixty infants at risk for IESS were monitored over the first year, with their heart rate data measured during sleep to identify patterns that might predict the condition's development.
- The findings suggest that higher sympathetic activity (measured by cardiac sympathetic index) and specific heart rate metrics at 2 months are associated with a higher likelihood of developing IESS, indicating that early HRV assessments could be useful for prognosis.
To evaluate clinicians' and patients' perceptions of pharmacogenetic testing in a clinical setting. This is a pragmatic mixed-method prospective observational study. Hospital pharmacists and neurologists participated in focus groups regarding pharmacogenetic testing; patients who received pharmacogenetic testing and their community pharmacists completed surveys to assess their perception of these tests.
View Article and Find Full Text PDFBackground: Therapeutic hypothermia (TH) without sedation may lead to discomfort, which may be associated with adverse consequences in neonates with hypoxic-ischemic encephalopathy (HIE). The aim of this study was to assess the association between level of exposure to opioids and temperature, with electroencephalography (EEG) background activity post-TH and magnetic resonance imaging (MRI) brain injury in neonates with HIE.
Methods: Thirty-one neonates with mild-to-moderate HIE who underwent TH were identified.
Objective: To characterize the neuropsychological outcome of children with congenital heart disease (CHD) at age 5 years; the stability of cognitive and language abilities across childhood; and to identify early neurodevelopmental markers of neuropsychological outcomes in these children.
Study Design: Five-year-old children (n = 55) with complex CHD were assessed using standardized and comprehensive neuropsychological measures. Stability of language and cognitive performance was assessed by comparing standardized scores between ages 1, 2, and 5 years old.
Nutrition and management of glycemia in neonates with neonatal encephalopathy treated with hypothermia.
Semin Fetal Neonatal Med
August 2021
Adequate nutrition and glycemic homeostasis are increasingly recognized as potentially neuroprotective for the developing brain. In the context of hypoxia-ischemia, evidence is scarce regarding optimal nutritional support and administration route, as well as the short- and long-term consequences of such interventions. In this review, we summarize current knowledge on disturbances of brain metabolism of glucose and substrates by hypoxia-ischemia, and compound effects of these mechanisms on brain injury characterized by specific patterns on EEG and MRI.
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- - Neonatal brain monitoring in the NICU relies on continuous EEG analysis, prompting the need for automated bedside assessment methods to evaluate cortical activity.
- - The study details the creation of a neonatal EEG background classifier, using a dataset from 27 infants with birth asphyxia, achieving a high classification accuracy of 97% across diverse subjects.
- - A set of 23 robust features was identified to enhance the classifier's performance, with the algorithm made publicly available for further clinical use and validation.
Objectives: To investigate how glucose abnormalities correlate with brain function on amplitude-integrated electroencephalography (aEEG) in infants with neonatal encephalopathy.
Study Design: Neonates born at full term with encephalopathy were enrolled within 6 hours of birth in a prospective cohort study at a pediatric academic referral hospital. Continuous interstitial glucose monitors and aEEG were placed soon after birth and continued for 3 days.
Aim: Neurodevelopmental outcomes in children with congenital cerebellar malformations (CCMs) remain poorly defined. We aimed to assess whether specific neuroimaging features in CCM patients correlate with neurodevelopmental outcomes.
Method: Hospital records and neuroimaging of 67 children with CCMs were systematically reviewed.
Distal 22q11.2 Microduplication: Case Report and Review of the Literature.
Child Neurol Open
November 2017
Distal chromosome 22q11.2 microduplications are associated with a wide range of phenotypes and unclear pathogenicity. The authors report on a 3-year-old girl with global developmental delay harboring a de novo 1.
View Article and Find Full Text PDFPurpose Of Review: Increasing recognition of electrographic seizures and electrographic status epilepticus in critically ill neonates and children has highlighted the importance of identifying their potential contributions to neurological outcomes to guide optimal management.
Recent Findings: Recent studies in children and neonates have found an independent association between increasing seizure burden and worse short-term and long-term outcomes, even after adjusting for other important contributors to outcome such as seizure cause and illness severity. The risk of worse neurological outcome has been shown to increase above a seizure burden threshold of 12-13 min/h, which is considerably lower than the conventional definition of status epilepticus of 30 min/h.
Background: Brain injury is one of the most common injuries in the pediatric age group, and post-traumatic headache is one of the most common symptoms following mild traumatic brain injury in children.
Methods: This is an expert opinion-based two-part review on pediatric post-traumatic headaches. Part I will focus on an overview and approach to the evaluation of post-traumatic headache.
Background: Post-traumatic headache is one of the most common symptoms occurring after mild traumatic brain injury in children.
Methods: This is an expert opinion-based two-part review on pediatric post-traumatic headaches. In part II, we focus on the medical management of post-traumatic headaches.
Objective: The purpose of this study was to describe the frequencies and relationships of non-specific non-essential diagnostic criteria and non-CNS organ system injury in term intra-partum asphyxia.
Methods: All children with term intra-partum asphyxia encountered in a single pediatric neurology practice with at least two years follow-up and an abnormal neurologic outcome were identified.
Results: A total of 40 children (28 males, 12 females) were identified.
Platelet transfusion reactions were prospectively studied in haematology/oncology patients at five university teaching hospitals over three consecutive summers. The initial summer study provided baseline information on the use of premedications and the rate of platelet transfusion reactions (fever, chills, rigors and hives). Most (73%) platelet recipients were premedicated and 30% (95% CI 28-33%) of transfusions were complicated by reactions.
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