Long-term water quality analysis reveals correlation between bacterial pollution and sea level rise in the northwestern Gulf of Mexico.

Long-term assessments are needed to identify water quality trends and their socio-environmental drivers for coastal management and watershed restoration. This study provides the first long-term assessment of fecal bacterial pollution in the northwestern Gulf of Mexico using enterococci data spanning the Texas coast from 2009 to 2020. The data were representative of 66 beaches, 169 stations, and over 75,000 samples.

Vascular co-localization of proteolytic enzymes and proteinase inhibitors in advanced periodontitis.

Sections of tissue biopsies obtained from advanced, destructive periodontitis were compared with minimally inflamed periodontal tissues in relation to the distribution of type I (interstitial) collagenase. Immunohistochemistry using a highly specific antiserum showed weak staining of occasional vessels in minimally inflamed specimens but widespread reactivity, localized to the vasculature, in advanced disease. In situ hybridization confirmed the vascular source of type I collagenase.

Microvascular angiopathy in advanced periodontal disease.

Previous studies have shown a perivascular hyaline thickening affecting restricted regions of the microcirculation in gingivitis and moderate periodontitis and in the pulpal vessels in chronic pulpitis. In the present study of the lesion of advanced periodontitis, immunostaining for type IV collagen and laminin demonstrated widespread deposition of basement membrane material, with manifest involvement of the venous network. Some vessels were associated with an increased deposition of both basement membrane proteins, while others showed preferential deposition of either laminin or type IV collagen.