Survival Outcomes of Patients with Primary Plasma Cell Leukemia in the Era of Proteasome Inhibitors and Immunomodulatory Agents: A Real-Life Multicenter Analysis.

Objective: In this study, we aimed to obtain real-life data on the use of antimyeloma agents, which significantly increase overall survival (OS) in multiple myeloma (MM) patients, in primary plasma cell leukemia (pPCL) patients with poor prognosis.

Materials And Methods: Data from 53 patients who were diagnosed with pPCL between 2011 and 2020 and who used at least one proteasome inhibitor (PI) and/or immunomodulatory (IMID) agent were analyzed retrospectively. Depending on the year of the pPCL diagnosis, 20% leukocytes or ≥2x10/L plasma cells in the peripheral blood was used as a diagnostic criterion.

Evaluation of contraception methods in chronic myeloid leukemia patients: A Turkish multicenter study.

Background And Aim: Chronic myeloid leukemia (CML) incidence has recently increased in younger individuals. With time, given the nature of the disease and available therapies, as well as the existing paucity and inconsistency of advice, worries about fertility have surfaced. With all these clear unknowns, we designed this study to raise awareness among both physicians and CML patients about whether male and female patients of childbearing age were using contraception at the time of diagnosis, and if so, which methods they were using.

Pressure Injury Prevalence and Risk Factors: A National Multicenter Analytical Study.

Purpose: The purpose of this study was to determine the point prevalence (PP) of general pressure injuries (PIs), hospital-acquired PIs, PI-related risk factors, and PI preventive interventions performed by nurses.

Design: Descriptive, multicenter, prospective, analytical study.

Subjects And Setting: The sample comprised 5088 patients cared for in 13 hospitals in 12 geographic regions of Turkey.

The Characterization and Beta-Lactam Resistance of Staphylococcal Community Recovered from Raw Bovine Milk.

Staphylococci is an opportunistic bacterial population that is permanent in the normal flora of milk and poses a serious threat to animal and human health with some virulence factors and antibiotic-resistance genes. This study was aimed at identifying staphylococcal species isolated from raw milk and to determine hemolysis, biofilm, coagulase activities, and beta-lactam resistance. The raw milk samples were collected from the Düzce (Türkiye) region, and the study data represent a first for this region.

The Prevalence of Species in the Fecal Microbiota of Farm Animals and Potential Effective Agents for Their Treatment: A Review of the Past Decade.

There is an endless demand for livestock-originated food, so it is necessary to elucidate the hazard points for livestock breeding. Pathogens are one of the hazard points that threaten the biosecurity of farm-animal breeding and public health. As a potential foodborne pathogen, is a member of the intestinal microbiota of farm animals with and without diarrhea.

Psychometric Evaluation of a Turkish Version of the Diabetes Fear of Self-injecting and Self-testing Questionnaire (D-FISQ).

Purpose: To examine the psychometric properties of a Turkish version of the Diabetes Fear of Injecting and Self-testing Questionnaire (D-FISQ).

Methods: Forward-backward translation of the D-FISQ from English into Turkish was conducted. Original English and translated forms were examined by a panel group.

Accessory tendon slip arising from the extensor carpi ulnaris and its importance for wrist pain.

Objective: The anatomical variations of the extensor carpi ulnaris (ECU) muscle can cause a functional impairment of the wrist and the little finger. The aim of this study was to determine the number, thickness and type of accessory tendon arising from the ECU.

Methods: The presence of an accessory tendinous slip from the ECU muscle was examined in terms of gross appearance, size, shape, thickness, location and distribution in 54 cadaveric forearms.

Regulatory-T, T-helper 1, and T-helper 2 cell differentiation in nasal mucosa of allergic rhinitis with olive pollen sensitivity.

Background: Allergic rhinitis (AR) is a disease in which T-helper (Th)2 response is predominant and its pathogenic mechanism is still poorly understood.

Aim: To evaluate the possible role of Th1, Th2 and regulatory-T (Treg) cells in the pathogenesis of AR.

Methods: This case-control study enrolled 41 patients with seasonal AR (10-62 years old), sensitive to olive pollens, and 15 healthy controls (18-60 years old).

Anatomical similarity between tendons and Type 3 intertendinous connections: suitability as local donor tissue.

Objective: A detailed anatomical knowledge of the extensor tendons of the hand is essential for accomplishing successful tendon repair. The aim of this study was to investigate the similarities between the extensor tendon and the thickest intertendinous connections (IC) in the 4th intermetacarpal space, where Type 3 IC is most frequently seen.

Methods: A total of 38 dissected hands were studied for anatomical structures that might serve as donor extensor tendons as well as for their relationship with the IC in the fourth intermetacarpal space of the dorsal hand.

Reliability and construct validity of the Health-Promoting Lifestyle Profile II in an adult Turkish population.

Background: Little is known about health-promoting lifestyle behaviors among Turkish people, who are experiencing a lifestyle transition from a developing country to one undergoing rapid modernization, although health promotion is receiving increasing attention regarding its prominent role in healthcare. Use of the Health-Promoting Lifestyle Profile II (HPLPII) has the advantage of allowing comparison of different international populations, although cultural adaptations are needed.

Objectives: The aims of this study were to adapt the HPLPII culturally and to assess its psychometric properties.

The types of talar articular facets and morphometric measurements of the human calcaneus bone on Turkish race.

Introduction: There are three facets over upper side of talocalcaneal joint: anterior talar facet, middle and posterior. Three types of calcaneus that have distinct talar facets were defined as types A, B and C.

Materials And Methods: A total of 221 calcanei (98 right, 123 left), with unknown gender, were dried and evaluated.

The anatomical variations of the extensor tendons to the dorsum of the hand.

To lead a quality life, tendon repair must be performed in a trauma causing damage to the extensor tendon of the hand. The aim of this study is to study the structures that can be used as donor tendons. Fifty-four dissected adult hands were examined to study the pattern of the extensor tendons on the dorsum of the hand.

Anatomo-histological analysis of the juncturae and their relations to the extensor tendons to the dorsum of the hand.

The juncturae tendinum (JT) may coordinate the extension of hand, force redistribution and the stabilization of the metacarpophalangeal joint. The JT were studied for their gross appearance, shape, thickness, location and histological examination with the dorsum of the hand in 54 cadavers. The JT were identified into three groups according to their anatomo-histological features.

Thorax deformity, joint hypermobility, and anxiety disorders.

Objective: To evaluate the association between thorax deformities, panic disorder, and joint hypermobility

Methods: The study includes 52 males diagnosed with thorax deformity, and 40 healthy male controls without thorax deformity, in Tatvan Bitlis and Isparta, Turkey. The study was carried out from 2004 to 2006. The teleradiographic and thoracic lateral images of the subjects were evaluated to obtain the Beighton scores; subjects' psychiatric conditions were evaluated using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-1), and the Hamilton Anxiety Scale (HAM-A) was applied in order to determine the anxiety levels.

Lower bone mineral density in geriatric patients with monoclonal gammopathy of undetermined significance.

The aim of this study was to investigate the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in a geriatric population in Turkey and compare bone mineral densities and related laboratory parameters of MGUS patients with those who do not have MGUS. Among 1,012 patients enrolled, monoclonal band was detected in serum samples of 22 patients (2.17%), most of which were IgG type.

Biochemical markers of bone turnover in diagnosis of myeloma bone disease.

This study was designed to explore the value of markers of bone turnover, macrophage inflammatory protein-1alpha (MIP-1alpha), and osteopontin (OPN) in the diagnosis of myeloma bone disease. Twenty-five patients with newly diagnosed and untreated multiple myeloma (MM), and 22 age-, sex-, and bone mineral density-matched control subjects were enrolled. Levels of MIP-1alpha, OPN, carboxy-terminal telopeptide of Type-1 collagen (C-telopeptide or Ctx), deoxypyridinoline (DPD), Type-1 collagen propeptide (T1Pro), and bone-specific alkaline phosphatase (BALP) were assessed in both groups.

Poplar pollen-related allergy in Ankara, Turkey: how important for patients living in a city with high pollen load?

The impact of high pollen load of particular plants on sensitized subjects is a topic of interest. We aimed to detect the clinical importance of poplar allergy in subjects with seasonal allergy living in Ankara, capital city of Turkey, having a high poplar pollen load. The subjects with seasonal allergy and demonstrating allergy to Populus alba in skin-prick tests (SPTs) (n = 20) underwent a specific nasal provocation test with P.

The association of plasma adiponectin levels with hypertensive retinopathy.

Objective: Previous studies have demonstrated that low plasma adiponectin concentrations are associated with essential hypertension. It has also recently been shown that adiponectin plays an essential role in the modulation of angiogenesis. These data led us to hypothesize that adiponectin might contribute to end-organ damage in hypertension.

Adiponectin may play a part in the pathogenesis of diabetic retinopathy.

Objectives: To measure plasma adiponectin concentrations in patients with type 2 diabetes and to investigate any association with the severity of diabetic retinopathy, because adiponectin seems to be an important modulator for metabolic and vascular diseases.

Methods: Seventy-four patients (mean age 46.8+/-5.

Direct cost assessments in subjects with seasonal allergic rhinitis living in Ankara, Turkey.

The characteristics of seasonal allergic rhinitis (SAR) including the severity at initial presentation and cost estimates are not established for Turkey. The aim of this study was to document the clinical features and direct cost of subjects with SAR when diagnosed and followed according to international treatment guidelines and to determine the effectiveness of treatment in relation to the regional pollen count in our country. The clinical features of SAR were determined cross-sectionally in 175 patients living in Ankara, Turkey.