Sesquiterpene Coumarins, Chromones, and Acetophenone Derivatives with Selective Cytotoxicities from the Roots of M. Bieb. (Apiaceae).

In search of selective cytotoxic compounds from species as potential leads for the treatment of various cancer diseases, a bioactivity-guided isolation study was performed on the roots of M. Bieb. COLO 205 (colon), K-562 (leukemia), and MCF-7 (breast) cancer cell lines were used to monitor the cytotoxic activity of column fractions and determine the IC value of the active compounds.

Sesquiterpene Coumarin Ethers with Selective Cytotoxic Activities from the Roots of Peşmen (Apiaceae) and Unequivocal Determination of the Absolute Stereochemistry of Samarcandin.

Ancient physicians frequently used the resin of species to treat cancer. Today, some folkloric recipes used for cancer treatment also contain the resin of species. The dichloromethane extract of the roots of exhibited cytotoxic activities against COLO 205 (colon), K-562 (lymphoblast), and MCF-7 (breast) cancer cell lines (IC = 52 µg/mL, 72 µg/mL, and 20 µg/mL, respectively).

Novel Cytotoxic Sesquiterpene Ester Derivatives from the Roots of Ferula mervynii.

This study is the first chemical investigation of Ferula mervynii M. Sağıroğlu & H. Duman, an endemic species to Eastern Anatolia.

Identification of /β-catenin mutations conferring cetuximab and chemotherapeutic drug resistance in colorectal cancer treatment.

In anticancer therapy, the effectiveness of therapeutics is limited by mutations causing drug resistance. mutations are the only determinant for cetuximab resistance in patients with colorectal cancer (CRC). However, cetuximab treatment has not been fully successful in the majority of patients with wild-type (WT) .

Antioxidant, Anti-acetylcholinesterase, Anti-inflammatory and DNA Protection Activities of ar. .

In this study, antioxidant, antiacetylcholinesterase, anti-inflammatory, and DNA protecting activities of the aerial parts of var. were evaluated. The lyophilized methanolic extract of the aerial parts of var.

Association of Three Single Nucleotide Polymorphisms in MTR and MTRR Genes with Lung Cancer in a Turkish Population.

Aims: Folate metabolism plays a critical role in DNA methylation and synthesis. Polymorphisms in folate metabolism may affect enzyme activities and thereby affect the cancer risk. Methionine synthase (MTR) and methionine synthase reductase (MTRR) are critical enzymes for the folate cycle.

Paraoxonase-1 192/55 polymorphisms and the risk of lung cancer in a Turkish population.

Aim: The purpose of the present study was to investigate the possible association of paraoxonase-1 (PON1) 192/55 polymorphisms with lung cancer (LC) risk in a Turkish population.

Materials And Methods: A population-based, case-control study was carried out, including 223 patients with LC and 234 controls. The frequencies of PON1 192/55 genotypes were compared in patient and control groups using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.