Publications by authors named "Pin-Lun Lin"
Analysis of various public databases revealed that gene mutation frequency and mRNA expression are higher in bladder urothelial carcinoma. Further analysis revealed the roles of oncogenic HRAS, autophagy, and cell senescence signaling in bladder cancer cells sensitized to the anticancer drug cisplatin using the phytochemical pterostilbene. A T24 cell line with the oncogenic was chosen for further experiments.
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- Ferroptosis is a new type of cell death dependent on iron and lipid-reactive oxygen species, with ferritinophagy playing a key role through the receptor NCOA4.
- Formosanin C (FC) has been identified as a novel inducer of ferroptosis, showing a significant reduction in cell viability and lipid ROS when combined with inhibitors.
- FC's effects are more pronounced in HepG2 cells with higher NCOA4 and lower ferritin heavy chain 1 levels, suggesting its potential as a treatment for apoptosis-resistant liver cancer due to its ability to induce ferroptosis via ferritinophagy.