Publications by authors named "Pin-Chao Ting"
Nucleic Acids Res
June 2024
Article Synopsis
- Orphan nuclear receptors (NRs) like COUP-TF1 and others are linked to telomerase-negative cancers that use an alternative mechanism (ALT) to maintain their telomeres, but their exact role in activating ALT is unknown.
- The study shows that when these orphan NRs are attached to telomeres in human fibroblasts, they trigger the formation of specific structures (APBs) and activate ALT processes, indicating that they can induce ALT from scratch.
- Overexpression of orphan NRs enhances ALT activity, while their removal decreases it, showing their critical role in promoting ALT, potentially offering a target for new therapies using agents like arsenic trioxide to inhibit ALT in cancer cells.
