The application of B1 inhomogeneity-corrected variable flip angle T1 mapping for assessing liver fibrosis.

Purpose: The aim of this study was to evaluate the diagnostic accuracy of the B1 inhomogeneity-corrected variable flip angle (VFA) method using native T1 values in the staging of liver fibrosis.

Methods: Eighty-three patients who presented for liver biopsy due to varying degrees of liver damage, underwent MR examinations and had T1-mapping images of the liver acquired using the B1 inhomogeneity-corrected VFA VIBE method. Among them, 65 patients underwent Fibroscan, and their results were used to evaluate the elasticity of liver tissue.

A novel splice variant in intron 10 of PEX6 is associated with Zellweger Syndrome in a Chinese neonate.

Background: Zellweger Syndrome (ZS), or cerebrohepatorenal syndrome, is a rare disorder due to PEX gene mutations affecting peroxisome function. While PEX6 coding mutations are known to cause ZS, the impact of noncoding mutations is less clear.

Methods: A Chinese neonate and his family were subjected to whole exome sequencing (WES) and bioinformatics to assess variant pathogenicity.

Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models.

Background: Diffusion-weighted imaging (DWI) has been developed to stage liver fibrosis. However, its diagnostic performance is inconsistent among studies. Therefore, it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one cohort.

HDAC9-mediated calmodulin deacetylation induces memory impairment in Alzheimer's disease.

Aims: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction and memory impairment. AD pathology involves protein acetylation. Previous studies have mainly focused on histone acetylation in AD, however, the roles of nonhistone acetylation in AD are less explored.

A guidebook of spatial transcriptomic technologies, data resources and analysis approaches.

Advances in transcriptomic technologies have deepened our understanding of the cellular gene expression programs of multicellular organisms and provided a theoretical basis for disease diagnosis and therapy. However, both bulk and single-cell RNA sequencing approaches lose the spatial context of cells within the tissue microenvironment, and the development of spatial transcriptomics has made overall bias-free access to both transcriptional information and spatial information possible. Here, we elaborate development of spatial transcriptomic technologies to help researchers select the best-suited technology for their goals and integrate the vast amounts of data to facilitate data accessibility and availability.

Metal ion assistant transformation strategy to synthesize catechol-based metal-organic frameworks from TiCT precursors.

Chemical transformation strategy is capable of fabricating nanomaterials with well-defined structures and fascinating performance via controllable crystallization kinetics in the phase transformation. VCT MXene has been used as precursors to fabricate vanadium porphyrin metal-organic frameworks (V-PMOFs) via the coordination of deprotonated carboxylic acid ligands. However, the rational and in-depth exploration of synthesis mechanism with the aim of enriching the variety of MXene (i.

Application of multi-echo Dixon and MRS in quantifying hepatic fat content and staging liver fibrosis.

This study associated the liver proton density fat fraction (PDFF), measured by multi-echo Dixon (ME-Dixon) and breath-hold single-voxel high-speed T2-corrected multi-echo H magnetic resonance spectroscopy (HISTO) at 1.5 T, with serum biomarkers and liver fibrosis stages. This prospective study enrolled 75 patients suspected of liver fibrosis and scheduled for liver biopsy and 23 healthy participants with normal liver function.

Effect of Health Education on Schistosomiasis Control Knowledge, Attitude, and Practice after Schistosomiasis Blocking: Results of a Longitudinal Observational Study in the Field.

Objectives: Schistosomiasis is a zoonotic infectious disease that seriously harms people's physical and mental health. As early as 1985, the WHO suggested that health education and health promotion should be the focus of schistosomiasis prevention work. This study aimed to explore the effect of health education on controlling the risk of schistosomiasis transmission after schistosomiasis blocking and to provide a scientific basis for the further improvement of intervention strategies after schistosomiasis interruption in China and other endemic countries.

deletion in microglia ameliorates chronic restraint stress induced mice depression-like behavior.

Major depression is one of the most common psychiatric disorders worldwide, inflicting suffering, significant reduction in life span, and financial burdens on families and society. Mounting evidence implicates that exposure to chronic stress can induce the dysregulation of the immune system, and the activation of brain-resident innate immune cells, microglia, leading to depression-like symptoms. However, the specific mechanisms need to be further elucidated.

2D Titanium carbide printed flexible ultrawideband monopole antenna for wireless communications.

Flexible titanium carbide (TiC) antenna offers a breakthrough in the penetration of information communications for the spread of Internet of Things (IoT) applications. Current configurations are constrained to multi-layer complicated designs due to the limited conformal integration of the dielectric substrate and additive-free TiC inks. Here, we report the flexible ultrawideband TiC monopole antenna by combining strategies of interfacial modification and advanced extrusion printing technology.

MRI View of Rehabilitation Methods to Relieve Anterior Cruciate Ligament Injury in Dancers.

In order to solve the problem of the difference in the diagnostic effect of different sequences of magnetic resonance imaging (MRI) examinations for anterior and posterior cruciate ligament injuries, the author proposes an MRI rehabilitation method to relieve anterior cruciate ligament injury in dancers. This method retrospectively analyzed the clinical data of 60 patients with knee anterior and posterior cruciate ligament injuries in our hospital, and all patients were diagnosed with knee anterior and posterior cruciate ligament injuries. All patients underwent MRI 3D sequence and 2D sequence examination successively to compare anatomical measurements.

MalFuzz: Coverage-guided fuzzing on deep learning-based malware classification model.

With the continuous development of deep learning, more and more domains use deep learning technique to solve key problems. The security issues of deep learning models have also received more and more attention. Nowadays, malware has become a huge security threat in cyberspace.

Social insights on the implementation of One Health in zoonosis prevention and control: a scoping review.

Background: The One Health (OH) concept has been promoted widely around the globe. OH framework is expected to be applied as an integrated approach to support addressing zoonotic diseases as a significant global health issue and to improve the efficiency and effectiveness of zoonosis prevention and control. This review is intended to overview the social impact of the implementation of OH on zoonosis prevention and control.

The experience of stereoblindness does not improve use of texture for slant perception.

Stereopsis is an important depth cue for normal people, but a subset of people suffer from stereoblindness and cannot use binocular disparity as a cue to depth. Does this experience of stereoblindness modulate use of other depth cues? We investigated this question by comparing perception of 3D slant from texture for stereoblind people and stereo-normal people. Subjects performed slant discrimination and slant estimation tasks using both monocular and binocular stimuli.

Investigation of optical texture properties as relative distance information for monocular guidance of reaching.

Reaches guided using monocular versus binocular vision have been found to be equally fast and accurate only when optical texture was available projected from a support surface across which the reach was performed. We now investigate what property of optical texture elements is used to perceive relative distance: image width, image height, or image shape. Participants performed reaches to match target distances.

SRC3 acetylates calmodulin in the mouse brain to regulate synaptic plasticity and fear learning.

Protein acetylation is a reversible posttranslational modification, which is regulated by lysine acetyltransferase (KAT) and lysine deacetyltransferase (KDAC). Although protein acetylation has been shown to regulate synaptic plasticity, this was mainly for histone protein acetylation. The function and regulation of nonhistone protein acetylation in synaptic plasticity and learning remain largely unknown.

Acetylation of calmodulin regulates synaptic plasticity and fear learning.

Synaptic plasticity is critical for brain function, including learning and memory. It is regulated by gene transcription and protein synthesis as well as posttranslational modifications at synapses. Although protein acetylation has been shown to be involved in the regulation of synaptic plasticity, this was mainly for histone protein acetylation.

Steroid Receptor Coactivator 3 Regulates Synaptic Plasticity and Hippocampus-dependent Memory.

Steroid hormones play important roles in brain development and function. The signaling of steroid hormones depends on the interaction between steroid receptors and their coactivators. Although the function of steroid receptor coactivators has been extensively studied in other tissues, their functions in the central nervous system are less well investigated.

The effect of the Müller-Lyer configuration on saccadic eye movements is not fully due to illusory perception.

Previous research has shown that both perception and oculomotor control are affected by visual illusions. While these findings appear to suggest a common code of visual processing for perception and oculomotor control, there remains the possibility that the perceptual and the oculomotor effects emerge through partially different processes. In three experiments, we replicated the previous finding that perception and saccades were both biased by the typical Müller-Lyer configurations.