A Randomized, Controlled Trial of Palonosetron Versus Ondansetron for Nausea, Vomiting, and Pruritus in Cesarean Delivery with Intrathecal Morphine.

Background: Spinal anesthesia is the preferred anesthetic technique for cesarean deliveries. Postoperative nausea and vomiting (PONV) and pruritus occur in up to 80% and 83% of patients, respectively, after cesarean delivery with intrathecal opioids. Ondansetron is the recommended medication for PONV prophylaxis, but palonosetron, a second-generation 5-HT3 receptor antagonist, has a higher receptor affinity and a longer half-life.

Preemptive analgesic efficacy of parecoxib vs placebo in infertile women undergoing diagnostic laparoscopy: randomized controlled trial.

Study Objective: To compare the preemptive analgesic efficacy between parecoxib and placebo in infertile women undergoing outpatient diagnostic laparoscopy.

Design: Double-blind, randomized, placebo-controlled study (Canadian Task Force classification I).

Setting: Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

A randomized controlled trial of pentazocine versus ondansetron for the treatment of intrathecal morphine-induced pruritus in patients undergoing cesarean delivery.

Background: Ondansetron is effective for the treatment of intrathecal morphine-induced pruritus. There is evidence that kappa-opioid receptor agonists have antipruritic activity. Pentazocine is an agonist of kappa-opioid receptors and partial agonist at mu-opioid receptors.

A survey of post anesthetic pain management in Thailand.

Objectives: The Royal College of Anesthesiologists of Thailand aimed to study status of post anesthetic pain management to determine factors for quality improvement of anesthesia services in Thailand.

Material And Method: A pre-planned structured questionnaire regarding demographic variables, early and late postoperative pain management, establishment of the post anesthesia care unit (PACU) was requested to be filled in by nurse anesthetists attending the refresher course lectures of the Royal College of Anesthesiologists of Thailand in August 2007.

Results: Of 280 questionnaires, 261 respondents (93%) returned the questionnaires.

The Thai Anesthesia Incident Monitoring Study (Thai AIMS) of postoperative central neurological complications.

Objective: To analyze the incidents of central neurological complication in the Thai Anesthesia Incident Monitoring Study (Thai AIMS).

Material And Method: A prospective descriptive multi-centered study of incident reports was conducted in 51 hospitals across Thailand from January to June 2007. Voluntary and anonymous reports of any adverse events during the first 24 hrs of anesthesia were sent to the Thai AIMS data management unit.

Factors related to intraoperative oxygen desaturation in geriatric patients in a Thai university hospital.

Background: As a site of the Thai Anesthesia Incidents Study (THAI Study) of anesthetic adverse outcome, the authors continued the institutional data collection to determine the incidence of intraoperative oxygen desaturation of geriatric patients (age 65 years and over) and relative factors representing a Thai university hospital.

Material And Method: Between July 1, 2003 and March 31, 2007, an anesthesia registry was conducted at King Chulalongkorn Memorial Hospital. Anesthesiologists and anesthesia residents were requested to record perioperative variables and adverse outcomes including oxygen desaturation (SpO2 < or = 90% for 3 minutes or SpO2 < 85%) on a structured data record form.

The incidence and risk factors of hypotension and bradycardia associated with spinal anesthesia.

Objectives: Hypotension and bradycardia after conduction of spinal anesthesia are common and may lead to intraoperative cardiac arrest or death. The present study was carried out to investigate the incidence and risk factors of hypotension and/or bradycardia in the patients receiving spinal anesthesia.

Material And Method: The authors prospectively studied 1,220 patients to identify the incidence of hypotension (> 30% decreased systolic blood pressure) and bradycardia (heart rate < 60 beats/min) after spinal anesthesia.

Parecoxib versus tramadol for post-appendectomy pain.

Unlabelled: Open uncomplicated appendectomy is known for low to medium degree of postoperative pain and a short hospital stay. Based on multimodal pain therapy, non-opioid analgesics have widely been a part in pain control. Parecoxib and tramadol have advantages over traditional opioids that are causing less nausea or vomiting, respiratory depression and sedation.

Lidocaine iontophoresis versus EMLA cream for CO2 laser treatment in seborrheic keratosis.

Background: Topical anesthesia for skin surgery has widely been used for a long time. Various preparations are used. The EMLA cream is the most popular one.

Maternal satisfaction to epidural and spinal anesthesia for cesarean section.

Background And Objective: The differences between epidural (EA) and spinal (SA) anesthesia that can affect maternal satisfaction are the procedures, quality of anesthesia and postoperative events. Dominantly, postoperative events such as postdural puncture headache, pruritus and nausea or vomiting after spinal anesthesia are claimed to be its disadvantages. However, maternal satisfactory perception to theses two techniques has not been revealed.

Factors related to patient satisfaction regarding spinal anesthesia.

Purpose: Regional anesthesia has been shown to improve the clinically oriented outcome and many studies investigating the use of regional anesthesia have incorporated patient satisfaction measurements. This study was undertaken to find the factors related to patient satisfaction after spinal anesthesia which is the most frequent regional anesthesia conducted.

Method: A prospective descriptive study of spinal anesthesia and post-operative survey of patients on the day after surgery was conducted by collecting pre-operative and intra-operative data on a constructed questionaire.

An optimal dose study of intrathecal morphine in gynecological patients.

Background And Objectives: Post-operative pain after gynecological surgery can be controlled by intrathecal administration of opioids and local anesthetics. Effective intrathecal analgesia can be achieved from low dose narcotics with less adverse effects, prolonged duration and reduced narcotics requirement. Therefore, we undertook a prospective randomized study to find out optimal dose of intrathecal morphine for long lasting post-operative analgesia with less adverse effect in this group of patients.