Publications by authors named "Pimpec-Barthes Francoise Le"
Acute respiratory failure due to pulmonary exacerbation in children with cystic fibrosis admitted in a pediatric intensive care unit: outcomes and factors associated with mortality.
Respir Res
April 2024
Article Synopsis
- Children with cystic fibrosis (CF) often face acute respiratory failure due to severe pulmonary exacerbations, leading to pediatric intensive care unit (PICU) admissions, with a focus on understanding their short and medium-term outcomes.
- A study reviewed data from patients under 18 years old admitted to a French PICU over two decades, utilizing statistical methods to identify factors influencing mortality and the need for lung transplants.
- Results indicated high mortality rates (up to 41% within 3 years post-discharge) and identified key risk factors like gender, certain blood gas levels, and pre-admission health conditions, highlighting the critical need for early consideration of lung transplants as a survival option.
Bone fragility and loss are a significant cause of morbidity in patients with cystic fibrosis (CF), and the lack of effective therapeutic options means that treatment is more often palliative rather than curative. A deeper understanding of the pathogenesis of CF-related bone disease (CFBD) is necessary to develop new therapies. Defective CF transmembrane conductance regulator (CFTR) protein and chronic inflammation in bone are important components of the CFBD development.
View Article and Find Full Text PDFBackground: T3 tumors can be divided into several subgroups depending on the type of anatomical structure invaded: chest wall, mediastinal pleura, or main bronchus. The aim of this study was to analyze the characteristics and prognosis of each subgroup of T3 tumors.
Methods: The results of surgical treatment were retrospectively analyzed for 261 patients with T3 non-small cell lung cancer invading either the mediastinal pleura or parietal pericardium by direct extension (mediastinal pT3, n = 68), or main bronchus (bronchial pT3, n = 68), or chest wall (chest wall pT3, n = 125) that were operated on between 1984 and 1996.