Publications by authors named "Pimpec-Barthes F"
Objectives: Ultrasound (US) measurements of diaphragmatic excursion (DE) are widely used to provide a non-invasive assessment of the diaphragmatic function at the bedside, especially in intensive care. However, this measurement has never been validated against a less operator-dependent technique such as MRI. Dynamic MRI is the only imaging modality that creates a four-dimensional reconstruction of the diaphragm.
View Article and Find Full Text PDFPatients with EGFR-mutated non-small cell lung cancer (NSCLC) benefit from treatment with tyrosine kinase inhibitors (TKI) targeting EGFR. Despite improvements in patient care, especially with the 3rd generation TKI osimertinib, disease relapse is observed in all patients. Among the various processes involved in TKI resistance, epithelial-to-mesenchymal transition (EMT) is far from being fully characterized.
View Article and Find Full Text PDFMetastatic non-small-cell lung cancer (NSCLC) displays various molecular alterations in the RAS-MAPK pathway. In particular, NSCLCs show high rates of targetable gene fusion in ALK, RET, ROS1, NRG1 and NTRK, or MET exon 14 skipping. Rapid and accurate detection of gene fusion in EGFR/KRAS/BRAF mutations is important for treatment selection especially for first-line indications.
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- The study analyzes the effects of lung transplant allocation policies in the USA and France, focusing on urgent lung transplants and their impact on patient outcomes.
- Using data from 2007 to 2017, the research found that urgent lung transplants had a higher risk of death, with survival rates significantly better in the US compared to France.
- The conclusion suggests that while urgent lung transplants are risky in both countries, the US score-based allocation system leads to better post-transplant survival rates, indicating a complex interplay of factors influencing outcomes.
Article Synopsis
- Children with cystic fibrosis (CF) often face acute respiratory failure due to severe pulmonary exacerbations, leading to pediatric intensive care unit (PICU) admissions, with a focus on understanding their short and medium-term outcomes.
- A study reviewed data from patients under 18 years old admitted to a French PICU over two decades, utilizing statistical methods to identify factors influencing mortality and the need for lung transplants.
- Results indicated high mortality rates (up to 41% within 3 years post-discharge) and identified key risk factors like gender, certain blood gas levels, and pre-admission health conditions, highlighting the critical need for early consideration of lung transplants as a survival option.
Introduction: Unlike most malignancies, higher body mass index (BMI) is associated with a reduced risk of lung cancer and improved prognosis after surgery. However, it remains controversial whether height, one of determinants of BMI, is associated with survival independently of BMI and other confounders.
Methods: We extracted data on all consecutive patients with resectable non-small cell lung cancer included in Epithor, the French Society of Thoracic and Cardiovascular Surgery database, over a 16-year period.
Article Synopsis
- Non-small cell lung cancer (NSCLC) often leads to compromised lung function, and this study focuses on the effects of surgical methods, specifically minimally invasive surgery (MIS), on 90-day post-operative mortality in high-risk patients.
- The research analyzed data from over 46,000 patients, identifying high-risk individuals with poor lung function, and found a significantly higher mortality rate in this group compared to low-risk patients.
- Results indicated that high-risk patients undergoing MIS had lower mortality rates than those undergoing traditional open surgery, even matching the mortality rates of low-risk patients.
Article Synopsis
- Researchers wanted to find a way to tell two types of lung tumors apart: hamartomas and carcinoids, using a special CT scan technique.
- They studied patients who had surgery for these tumors and used some advanced computer methods to analyze the CT images.
- The study found that using a specific measurement from the scans, called 3D-median, was very good at predicting which tumor was which, helping doctors make better decisions in treatment.
Article Synopsis
- - The study focuses on lung adenocarcinoma (LUAD) and introduces a miR-200 based RNA signature that helps predict survival rates beyond existing classification methods, especially as therapies are moving to earlier stages of the disease.
- - Using RNA sequencing, researchers identified three different clusters of tumors based on their miR-200 signature, each associated with specific genetic mutations, and assessed various biological processes and immune responses connected to these clusters.
- - The miR-200 signature effectively stratified patients into high- and low-risk groups, showing that those with a higher signature had longer disease-free survival, suggesting its potential for improving prognosis evaluations and guiding treatment plans in LUAD.
Middle lobe suffering due to malposition and 180° tilt of the 2 remaining lobes after right upper lobectomy.
Interdiscip Cardiovasc Thorac Surg
February 2023
Middle lobe (ML) suffering after right upper lobectomy (RUL) is rare but represents a major complication usually due to lobar torsion. We report 3 atypical consecutive cases of ML suffering due to malposition of the 2 remaining right lobes with a 180° tilt. All 3 female patients had surgery for non-small-cell carcinoma including RUL associated with radical hilar and mediastinal lymph node removal.
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- The study aims to create a user-friendly nomogram to predict long-term outcomes for patients with resectable non-small cell lung cancer (NSCLC), helping to identify those at high risk during cancer treatment planning.
- Researchers analyzed clinical data from over 62,000 patients treated between 2003 and 2020, utilizing Cox modeling to identify key prognostic factors, leading to the development of sex-specific nomograms.
- Results showed a median survival of 9.2 years, with significant differences in overall survival rates based on the prognostic scoring system, confirming that this composite score can effectively predict survival after NSCLC surgery.
Background: The IONESCO (IFCT-1601) trial assessed the feasibility of neoadjuvant durvalumab, for early-stage resectable non-small-cell lung cancer (NSCLC).
Methods: In a multicenter, single-arm, phase II trial, patients with IB (≥4 cm)-IIIA, non-N2, resectable NSCLC received three doses of durvalumab (750 mg every 2 weeks) and underwent surgery between 2 and 14 days after the last infusion. The primary endpoint was the complete surgical resection rate.
The authors present a new study on 789 cases of congenital thoracic malformations including 638 pectus excavatum and 151 Poland syndromes, according to a new classification which completes Chin's one. All these malformations were treated with silicone elastomer implants. The contribution of computer-aided design and manufacturing (CAD/CAM) since 2008 is essential.
View Article and Find Full Text PDFExtreme mediastinal shift due to major diaphragm eventration is complex when mitral-valve repair is required. We report the case of a 59-year-old woman with diaphragmatic eventration who had 2 recent episodes of heart failure due to arrythmia associated with severe mitral-valve regurgitation (regurgitant orifice area 47 mm2). Forced expiratory flow-volume in the first second and vital capacity (VC) were at 32% and 33%, respectively,decreasing to 20% and 30% when she was in a supine position.
View Article and Find Full Text PDFIntroduction: Donor to recipient (D-R) matching in lung transplantation (LTx) is firstly directed by blood group (identity or compatibility), immunological status and morphological criteria. Sex matching is ignored and impact on outcome less investigated.
Evidence Acquisition: Systematic review of English literature using PubMed (1990-2019) was performed to evaluate the potential role of D-R matching in determining long-term outcome in patients after LTx.
Background: There is a paucity of data regarding the prognostic influence of peripheral blood CD4+ T lymphopenia in non-small cell lung cancer (NSCLC). Therefore, we investigated the prognostic value of T lymphopenia in NSCLC.
Materials: Treatment-naive patients with a pathological diagnosis of NSCLC, at clinical stage I to IV were included in the prospective TELOCAP1 study.
Vascular Ehlers-Danlos syndrome is a hereditary disorder of the connective tissue characterized by a reduction in the production of type III collagen. Clinical evolution of the disease is unpredictable because vascular lesions can occur everywhere in the body. Bruising, arterial and bowel fragility, and uterine fragility during pregnancy are the most common symptoms.
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- Ultrasound is used to assess diaphragmatic function non-invasively in patients undergoing thoracic surgery, focusing on diaphragmatic excursion (DE) and thickening fraction (DTF).
- A study with 50 patients found significant decreases in DE/DTF on the operated side immediately after surgery and three days post-op compared to pre-surgery and the non-operated side.
- Persistent diaphragmatic dysfunction on the operated side was linked to higher risks of lung infections, ICU admissions, and longer hospital stays.
Superior vena cava graft infection in thoracic surgery: a retrospective study of the French EPITHOR database.
Interact Cardiovasc Thorac Surg
February 2022
Article Synopsis
- The study investigates the management of infections related to synthetic grafts used in the superior vena cava between 2001 and 2018, based on data from the French EPITHOR database.
- Out of 111 patients studied, 12 developed graft infections primarily due to contamination, with management including either conservative treatment or a surgical approach depending on the severity of the infection.
- The results indicate a 25% operative mortality rate and suggest that while graft removal isn't always required, it should be considered for severe or recurrent infections.
Background: Patients with non-small cell lung cancer (NSCLC) receiving curative surgery have a risk of relapse, and adjuvant treatments only translate into a 5% increase in 5-year survival. We assessed the clinical significance of epithelial-mesenchymal transition (EMT) and explored its association with the [SNAIL/miR-34]:[ZEB/miR-200] regulation hub to refine prognostic information.
Methods: We validated a 7-gene EMT score using a consecutive series of 176 resected NSCLC.
Background: Surgical lung biopsy is essential in the diagnostic algorithm of interstitial lung disease (ILD) of unknown cause. Safety concerns have been recently reiterated. This study prospectively assessed the yield of diagnosis and safety of video-assisted thoracoscopic surgical lung biopsy (VATS-LB) for ILD diagnosis.
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