[Nipple discharge without palpable tumor. Experience of the Institut Curie from 1970 to 1984].

Four hundred and ten women with serous or bleeding nipple discharge without palpable mass were treated by surgery in the Curie Institute between 1970 and 1984. The cancer rate in this group was 12.2 per cent.

[Prognostic value of the Lauren and Ming classifications in gastric adenocarcinoma. Multidimensional analysis].

Of the various pathology classifications for gastric carcinoma, those of Lauren and of Ming have been claimed to be of prognostic value. We therefore reviewed the charts of 101 patients (mean age 64 +/- 11 years) treated for gastric carcinoma between 1960 and 1983 at the Institut Curie. We excluded the following patients: 1) those with distant metastases; 2) those who were not operated on; 3) those who underwent laparotomy only, and 4) those who had a palliative procedure.

Desmoid tumors in adults: the role of radiotherapy in their management.

Twenty-six adult patients with the pathologic diagnosis of desmoid tumor were treated between 1964 and 1983 at the Institut Curie in Paris with megavoltage irradiation. Twenty of these patients (76 percent) had extraabdominal tumors. Definitive surgical resection was performed on nine patients (one received preoperative radiotherapy).

[Lymphoceles and peritonization following lymphadenectomy for cancer of the uterus].

Pelvic lymphocysts following lymphadenectomy in the management of cervical and corporeal uterine carcinoma are recorded in one third of the cases and require surgery in 2-3% of cases. In order to prevent these lymphocysts, peritoneal suturing in front of the lymph node dissection area was progressively abandoned in order to allow peritoneal resorption of the lymph. A retrospective study analysed 226 iliac lymphadenectomies between 1982-1986 for uterine cancer treated at the Institut Curie.

[Conservative surgery after preoperative radiotherapy in the treatment of breast cancer. Indications and results].

From 1969 to 1983, 122 patients with unifocal breast cancer, equal or more than 3 centimeters in diameter, NON1a or N1b, were treated at the Institut Curie with conservative surgery after pre-operative external irradiation. Among them were 68% T2NON1a, and 26% N1b (with 21% T2N1b); 80% of the tumors were located in the upper part of the breast. Initial radiotherapy with a moderate dose (50 to 55 Gy for the breast and the lower axillary area) was followed 6 weeks later by a lumpectomy either alone (42 cases) or associated to an axillary node resection (80 cases).

[Amputation of the rectum by the perineosacral approach for anorectal cancer. Indications, results. Apropos of 27 cases].

Twenty seven patients were operated on by perineo-sacral route for anal or rectal cancer. This technique used between 1965-1982 at the Institut Curie was selected because the patients were very old and/or presented with major visceral disease, where the abdomino-perineal resection was not indicated. There was no post-operative death.

[Prevention of postoperative lymphocele after breast amputation].

Closed suction drainage is widely used after modified radical mastectomy to prevent accumulation of serum or lymph and to promote adherence of the skin flaps to the chest wall. However, between 5 and 35% of the patients develop seroma, which may prolong their stay in hospital and require more frequent post-operative outpatient visits. The prospective study reported demonstrate a significant correlation between the incidence of post-operative seromas, the duration of suction drainage and the amounts of fluid drained.

Wide excision of the tumor, axillary dissection, and postoperative radiotherapy as treatment of small breast cancers.

A retrospective study was carried out on 265 patients with small cancers of the breast who were subjected to wide excision of the tumor, axillary dissection, and postoperative radiotherapy. In the group of patients with T1, T2 less than 3 cm, N0, N1a (which represents 90% of all patients in the study), axillary lymph node involvement was found in 27% of cases, and in 11% three nodes or more were affected. Only five cases of recurrences occurred during the follow-up, and 19 patients presented distant metastases.

Treatment of epidermoid anal canal cancer.

Between 1968 and 1979, 183 patients with invasive epidermoid cancer of the anal canal were treated at Institut Curie. There was 156 women, 27 men with a mean age of 67 +/- 11 years (range 40 to 85 years). The initial height of the tumor was less than 4 cm (65 patients), 4 to 6 cm (98 patients), and more than 6 cm (20 patients).

[Angiosarcoma of the breast].

Since angiosarcoma of the breast was first reported in 1907 fewer than one hundred cases have been reported. They are primary malignant vascular mesenchymal tumors occurring in young females. Their prognosis is very bad.

[Prognosis of breast epithelioma detected by microcalcifications in the absence of a palpable tumor].

A retrospective study of 65 patients with unpalpable breast cancer revealed by microcalcifications on mammography showed that 18 had presented with infiltrating epithelioma. The contralateral epithelioma was revealed by mammography. Three deaths from metastases had occurred in this group.

[Operable cancers of the rectum: preoperative radiotherapy. Retrospective study of 192 cases treated at the Curie Institute].

Pre-operative irradiation in operable cancer of the rectum remains controversial. This is a report of a retrospective study about 192 patients treated between 1958 and 1980 at the Institut Curie (Paris) for a rectal cancer. An abdomino-perineal resection was done in 144 patients, 83 as a primary procedure and 61 after a pre-operative irradiation.

[Glandular cancer of the cervix in the initial stages. Treatment and results at the Curie Institute].

102 patients were treated for adenocarcinoma of the cervix, stage 1 and 2, by radiotherapy and surgery at the Curie Institute between the years 1955 and 1974. Glandular carcinoma represents about 10% of cancers of the uterine cervix. The survival rate is: at five years 81%, at ten years 78%, at fifteen years 74%.

[Phyllodes tumors of the breast. Apropos of 83 cases].

Twelve recurrences after surgical treatment of 83 cystosarcoma phyllodes of the breast were reported. The histology of the initial tumor was benign (n = 73), borderline (n = 6), sarcoma (n greater than 4). Nine recurrences were observed at the initial site of the tumor (2 in another quadrant of the same breast and I in the contralateral breast).

[Estrogenic paradox: treatment of ulcerated or atrophic scirrhous carcinoma of the breast in elderly women. A method not to be forgotten].

The authors report their experience in the treatment of advanced scirrhous carcinoma of the breast with estrogens only at the Curie Institute. Patients were elderly women in whom other forms of treatment were contraindicated because of local tumor extension or a poor general condition related to age. 32.

[Symposium on the management of early breast cancer (stages I and II). Part II: Clinical experience with treatment methods. 2. Conservative surgery followed by cobalt therapy in the treatment of breast cancer].

At the Institut Curie in Paris 452 invasive breast cancers (T1 and T2 less than 3 cm in diameter) were managed conservatively. The patients were treated by "conservative" surgery with or without axillary dissection. All received radiotherapy postoperatively.