Hyperthyroidism in gestational trophoblastic neoplasia.

The thyroid status of twenty-seven African patients with gestational trophoblastic neoplasia (GTN) was studied. Fifteen patients were found to be biochemically hyperthyroid (eight patients with choriocarcinoma; seven with hydatidiform mole). Of these fifteen patients, nine were clinically thyrotoxic.

Insulin-dependent diabetes mellitus with early onset in blacks and Indians.

Insulin-dependent diabetes mellitus (IDDM) with onset below 35 years of age was studied in 52 Black and 38 Indian patients. IDDM accounted for approximately 10.4% and 1.

Non-insulin-dependent diabetes mellitus with early onset in Blacks and Indians.

Non-insulin-dependent diabetes mellitus (NIDDM) with onset below 35 years of age was studies in 43 Indian and 9 Black patients. NIDDM was diagnosed in 10.0% and 1.

Hypopituitarism. A 3-year study.

During a 3-year period of 16 Black and Indian patients were diagnosed as having hypopituitarism. Their ages ranged from 9 to 58 years; 9 were women. Headaches and visual disturbances constituted the commonest presenting symptoms, and this was related to the fact that tumours accounted for the hypopituitarism in 11 of the 16 patients.

Radio-iodine-induced hypoparathyroidism. A case report.

A 46-year-old Black woman who was treated with 131I for hyperthyroidism subsequently developed hypoparathyroidism, a very rare complication. The clinical and biochemical findings are presented and the relevant literature is discussed.

Serum angiotensin-converting enzyme in sarcoidosis.

Serum angiotensin-converting enzyme (SACE) activity was measured in 29 patients with sarcoidosis, 51 reference subjects, 7 patients with active tuberculosis and 8 patients with other lung diseases. SACE activity was increased in 93% of the patients with sarcoidosis as compared with the reference subjects. Patients with active tuberculosis and other lung diseases did not have increased SACE activity.

Cryptococcal meningitis: our experience in 24 black patients.

The records of 24 patients with cryptococcal meningitis, admitted to King Edward VIII Hospital in Durban, were reviewed. There were 21 adults and 3 children over periods of 10 and 18 years, respectively. Slightly more males were affected.

Comparative trial of amoxycillin and chloramphenicol in treatment of typhoid fever in adults.

A randomised clinical trial in 124 adult patients with typhoid fever, proved by blood culture, showed that amoxycillin in a dosage of 1 g. six-hourly for fourteen days is an alternative to chloramphenicol, which has hitherto been regarded as the drug of choice.

Probable chloroquine-resistant Plasmodium falciparum malaria from Mozambique A case report.

A female patient with Plasmodium falciparum malaria apparently resistant to chloroquine is descirbed. She had recently returned from Mozambique, which may prove to be a new endemic are with resistant strains. The infection was successfully treated with quinine.