Comparison of digital recruitment strategies for Alzheimer's disease patients.

Objectives: Clinical trials studying Alzheimer's Disease (AD) face the challenge of recruiting participants with significant barriers to entering research studies. The objective of this study is to compare digital recruitment strategies' ability to recruit older adults with cognitive impairment (CI).

Methods: Older adults with CI were recruited for a clinical trial studying vestibular therapy in reducing falls and improving balance and cognition in older adults with CI.

Local spatial navigation or "steering" in patients with vestibular loss in a virtual reality environment.

Background: Patients with vestibular loss have reduced wayfinding ability, but the association between vestibular loss and impaired steering spatial navigation is unclear.

Objective: To evaluate whether vestibular loss is associated with reduced steering navigation performance in a virtual reality (VR) environment containing obstacles.

Methods: 17 ambulatory adults with vestibular loss were age/sex-matched to healthy controls.

Quantitative vestibular assessment: The development and validation of a novel, remote video head impulse test against in-clinic measurements.

Objectives: To develop a novel remote head impulse test (rHIT), and to provide preliminary data validating the rHIT vestibular-ocular reflex (VOR) gains against the in-clinic vHIT.

Methods: A convenience sample of 10 patients referred for vestibular assessment at our institution was recruited. In-clinic vHIT was used to quantify lateral VOR gains.

BTrackS limits of stability test is a reliable assessment of volitional dynamic postural control.

Background: Unconstrained limits of stability assessment reveals aspects of volitional postural sway control that are inaccessible by other means. Prior versions of this assessment include instructions to sway towards predefined targets, and may not capture the full capability of the individual.

Research Question: This study sought to establish the test-retest reliability of a novel limits of stability protocol.

Depressive Symptom Trajectories Among People Living with HIV in a Collaborative Care Program.

Depressive symptoms may differ in severity and change over time in people living with HIV (PLWH). Describing depression trajectories and associated clinical characteristics of PLWH in an interventional study may help in developing a more personalized medicine approach. Using latent class growth analysis four, 15-month self-reported depression trajectories were identified in 416 PLWH participating in a collaborative care program.

Convenient synthesis of mosquito oviposition pheromone and a highly fluorinated analog retaining biological activity.

A simple three-step synthesis is described for 6-acetoxy-5-hexadecanolide, the oviposition pheromone of the mosquitoCulex quinquefasciatus Say and others in that genus. An aldol condensation between 1-trimethylsilyloxycyclopent-1-ene and undecanal, followed by Baeyer-Villiger ring expansion and acetylation, gave the required compound as a 1∶1 mixture of diastereoisomers in high overall yield (>80%). This synthetic approach is readily adapted for synthesis of analogs.

Anthropophagy and aggregation behaviour of the sandfly Phlebotomus argentipes in Sri Lanka.

The visceral leishmaniasis (VL) vector Phlebotomus argentipes Annandale & Brunetti is widely distributed throughout the Indian sub-continent and S.E. Asia.