Tissue plasminogen activator for acute ischemic stroke: calculation of dose based on estimated patient weight can increase the risk of cerebral bleeding.

A dose of 0.9 mg/kg of intravenous tissue plasminogen activator (t-PA) has proven to be beneficial in the treatment of acute ischemic stroke (AIS). Dosing of t-PA based on estimated patient weight (PW) increases the likelihood of errors.

Vascular imaging before intravenous thrombolysis: consequences of in-hospital delay in applying two diagnostic procedures.

Background: Vascular imaging is increasingly used for diagnosis of arterial occlusions in acute ischemic stroke (AIS) patients. Our aim was to determine whether computed tomography angiography (CTA) and Doppler/duplex ultrasound (DUS) before intravenous thrombolysis (IVT) is associated with a delay in time-to-treatment.

Methods: Observational analysis of a prospective cohort of AIS patients treated with IVT from January 2009 to December 2012.

[Bilateral carotid artery occlusion: prognosis and neurosonological features].

Introduction: Bilateral carotid artery occlusion (BCAO) is a rare and poorly studied entity. The medium-long term prognosis reported is variable. Collateral circulation must play a crucial role in the outcome, however, the evidence in literature is scarce.