Publications by authors named "Pilar Samper Villagrasa"
Introduction And Objective: Arachnoid cysts (ACs) are relatively frequent lesions related to different neurological symptoms, being mostly incidentally diagnosed. This study aims to clarify whether AC surgery in epileptic patients is useful in their treatment.
Material And Methods: The patients registered in the database of the Neuropediatrics Section from May 1990 to August 2019 are analyzed retrospectively.
Article Synopsis
- Neonatal screening for cystic fibrosis (CF) has improved early diagnosis and survival rates, but it often yields false positives due to low specificity.* -
- A study analyzed immunoreactive trypsin (IRT) levels in newborns with positive CF screens, identifying higher IRT concentrations in those with CF compared to healthy newborns, carriers, or those with inconclusive diagnoses.* -
- The study found a significant correlation between IRT levels and sweat test results, suggesting that higher IRT values could be used to improve CF diagnosis, specifically with a cut-off of 76.2 ng/mL.*
Introduction And Objective: Arachnoid cysts (ACs) are relatively frequent lesions related to different neurological symptoms, being mostly incidentally diagnosed. This study aims to clarify whether AC surgery in epileptic patients is useful in their treatment.
Material And Methods: The patients registered in the database of the Neuropediatrics Section from May 1990 to August 2019 are analyzed retrospectively.
Article Synopsis
- Survivors of childhood acute leukemia are at an increased risk for obesity, and a study aimed to assess various methods for measuring body composition compared to BMI.
- The study involved 39 survivors who had been in remission for over ten years, using different measurements like waist circumference and bioelectrical impedance analysis to evaluate their body fat percentage.
- Results indicated that BMI significantly underestimated body fat among survivors, with waist circumference being the most accurate predictor of cardiovascular risk, while factors such as female sex and past treatments like radiotherapy increased obesity risk.
Article Synopsis
- Myocardial deformation using speckle tracking echocardiography is a new technique for assessing heart function in fetuses.
- A study of 154 healthy fetuses tracked the development of heart strain mechanics, revealing age-specific differences in right and left ventricular function.
- Results showed that left ventricle strain is consistently higher than right ventricle strain, with both decreasing over gestation, indicating that these measurements can help compare healthy and diseased heart function in future studies.
Article Synopsis
- Long-term childhood cancer survivors, particularly those treated for acute leukemia, face an increased risk of cardiac issues due to the side effects of their treatments.
- A study showed that both fractional shortening and ejection fraction significantly decreased 10 years after treatment, particularly during the first year post-treatment.
- Factors like younger age at diagnosis and receipt of high-risk treatments, such as hematopoietic stem cell transplantation and total body radiation, were associated with greater declines in heart function.
Article Synopsis
- Survivors of childhood acute lymphoblastic leukaemia (AL) face long-term health issues and a decline in quality of life due to treatment effects and other related conditions.
- A study of 54 survivors revealed that over half developed multiple health problems, with common conditions including hypothyroidism and obesity, and a significant number reported reduced quality of life.
- Despite challenges, overall quality of life in these survivors was still rated as very good, often exceeding that of the general population, although certain groups (like females and high-risk patients) experienced greater difficulties.
Use of speckle tracking in the evaluation of late subclinical myocardial damage in survivors of childhood acute leukaemia.
Int J Cardiovasc Imaging
September 2018
Heart disease is the leading cause of non-cancer death in childhood cancer survivors. to determine the prevalence of subclinical cardiac dysfunction using speckle tracking and compare its results with those obtained by classical methods of assessing left ventricular function and its relationship with different factors to identify the population at higher risk. Echocardiographic assessment of left ventricular function included ejection fraction, tissue Doppler, longitudinal/circumferential strains and biochemical parameters (troponin-T and Pro-BNP) in a cohort of 57 survivors of childhood acute leukaemia with at least 10 years since diagnosis.
View Article and Find Full Text PDFIntroduction And Objectives: Small for gestational age (SGA) patients have an increased risk of developing a cardiovascular pathology, as well as a metabolic syndrome. Our objective is to evaluate the cardiac morphology and function of SGA children treated with growth hormone (GH), identifying changes that could potentially have long-term consequences.
Methods: We selected 23 SGA school-age patients and 23 healthy children.
Introducción: los supervivientes de leucemia aguda (LA) infantil presentan un riesgo incrementado de alteraciones metabólicas y cardiovasculares que aumentan su morbimortalidad a largo plazo.Objetivo: estimar la prevalencia de obesidad, resistencia a la insulina, dislipemia e hipertensión arterial como factores de riesgo cardiometabólico (FRCM) en un grupo de supervivientes de LA infantil, y analizar las posibles causas asociadas a su desarrollo.Material y métodos: estudio observacional retrospectivo en 47 supervivientes de LA tratados en un periodo de 4 años, que recibieron seguimiento durante 10 años.
View Article and Find Full Text PDFBackground And Objectives: Small for gestational age (SGA) children are at increased risk of metabolic syndrome. Our objective is to evaluate changes in body composition produced by growth hormone (GH) treatment.
Patients And Method: A group of 28 SGA children without catch-up growth and undergoing treatment with GH was selected for evaluation.
Objective: A study of epilepsy, according to the age at onset of the crisis and its causes, monitored by a Paediatric Neurology Unit over a period of three years.
Patients And Methods: Historical cohorts study was conducted by reviewing the Paediatric Neurology medical records data base of epileptic children followed-up from 1 January 2008 to 31 December 2010.
Results: A total of 4,595 children were attended during the study period.
Article Synopsis
- Small for gestational age (SGA) children undergoing growth hormone (rhGH) treatment show significant improvements in height, weight, and growth rate, but require careful monitoring for metabolic syndrome risks.
- A study of 28 SGA children revealed improvements in body composition, with increased lean mass and reduced fat mass, though insulin levels and related metrics indicated emerging insulin resistance.
- While rhGH treatment effectively enhances growth and alters body composition in SGA patients, ongoing follow-up is essential to assess the long-term implications of these changes on health as they reach adulthood.
Aim: To analyze the factors involved in the prognosis of symptomatic epilepsies in relation to their age at onset, monitored at a neuropediatric section of regional reference over a period of three years.
Patients And Methods: Children diagnosed with symptomatic epilepsy, supervised from January 1, 2008 to December 31, 2010, collecting epidemiological, clinical and developmental data.
Results: Of the 4595 children attended during the period, the diagnosis of epilepsy was established at 605 (13.
Aim: To analyze the factors involved in the prognosis of non-symptomatic epilepsy (idiopathic and cryptogenic) in relation to their age of onset, monitored at a regional section of Neuropediatry reference over a period of three years.
Patients And Methods: Patients with diagnosis of non-symptomatic epilepsy supervised from January 1, 2008 to December 31, 2010, collecting epidemiological, clinical, complementary examinations and developmental data.
Results: Of the 4595 children attended during the period, the diagnosis of epilepsy was established in 605 (13.
Objective: To check whether secular changes exist in growth pattern of caucasic children from the North of Spain up to 2 years of age compared with 25-30 years ago population growth curves.
Material And Methods: Longitudinal study of a representative cohort of caucasic infants born a term in Aragon (n=1.099).