Publications by authors named "Pilar Martinez Matsumoto"
Article Synopsis
- The study investigates the role of TLR7 and MyD88 gene polymorphisms in the severity of COVID-19 among unvaccinated individuals, analyzing a population of 618 patients.
- A significant association was found between specific genetic variations (rs3853839 for TLR7 and rs7744 for MyD88) and worse clinical outcomes, with specific genotypes linked to critical and severe cases.
- The findings suggest that these genetic markers could help predict COVID-19 severity and are associated with immune response factors like D-dimer and IFN-α concentrations.
It has been shown that Fas, Fas-L, TNF and TNFR-1 display high serum concentrations in subjects with sepsis. This suggests that these are potential severity markers. However, the serum concentration of these molecules in children with leukemia and suspected sepsis has to be established before proposing their use as diagnostic biomarkers.
View Article and Find Full Text PDFAmong cancer and septic patients, there is a deregulation of common events such as inflammation. This fact limits the use of biomarkers to diagnose sepsis. Through a search in the PubMed database, we identified the clinical studies that evaluated procalcitonin as a biomarker among children with cancer and sepsis; we analyzed its characteristics, advantages and disadvantages.
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