Publications by authors named "Pilar Marcos Rabal"
Article Synopsis
- The medial temporal lobe (MTL) cortex, essential for memory and vulnerable to diseases like Alzheimer's, consists of various subregions with distinct functions and structures.
- This study compares the cytoarchitectonic definitions of specific areas within the MTL cortex provided by four different neuroanatomists to assess overlapping and differing delineations among them.
- Findings revealed more consensus on the entorhinal cortex and Brodmann area 35, while there was less agreement on Brodmann area 36 and the parahippocampal cortex, particularly in transitional zones where defining features are not as clear.
Tau neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer's disease (AD). To elucidate patterns of structural change in the MTL specifically associated with tau pathology, we compared high-resolution ex vivo MRI scans of human postmortem MTL specimens with histology-based pathological assessments of the MTL. MTL specimens were obtained from twenty-nine brain donors, including patients with AD, other dementias, and individuals with no known history of neurological disease.
View Article and Find Full Text PDFThe rapid pattern of population ageing in recent years increases the risk of appearance of associated neurodegenerative diseases. Dementias are one of the most feared disorders, and although not necessarily all elderly people have dementia, the number of people with this disease is increasing rapidly. The causes of dementia are multiple, and the diagnosis of the different types of dementia is complicated since most patients display mixed dementias and symptoms overlapping.
View Article and Find Full Text PDFArticle Synopsis
- The angular bundle is a fiber pathway in the brain that connects the entorhinal cortex to the hippocampus and carries information to and from various parts of the brain.
- It is present prenatally, with neural connections forming by the 20th week of gestation, and shows increased myelination postnatally.
- A study of neurons that express neuropeptide Y and Somatostatin-28 in the angular bundle revealed that their density is highest around birth but significantly decreases after 2 years of age.