Publications by authors named "Pilar Hereu"
Article Synopsis
- Acute pancreatitis (AP) is an inflammatory condition with various causes, including drugs, which account for a small percentage of cases; diagnosing drug-induced AP is often complicated due to a lack of specific symptoms.
- A study conducted at Hospital Universitari de Bellvitge analyzed 38 patients with suspected drug-induced AP from June 2007 to March 2023, revealing that most cases were linked to a single drug, with azathioprine and atorvastatin being the most common culprits.
- The findings suggest that increased awareness and a proposed diagnostic algorithm may improve the identification and management of drug-induced pancreatitis, highlighting the need for drug assessment when diagnosing AP.
To explore preoperative and operative risk factors for red blood cell (RBC) transfusion requirements during liver transplantation (LT) and up to 24 h afterwards. We evaluated the associations between risk factors and units of RBC transfused in 176 LT patients using a log-binomial regression model. Relative risk was adjusted for age, sex, and the model for end-stage liver disease score (MELD) (adjustment 1) and baseline hemoglobin concentration (adjustment 2).
View Article and Find Full Text PDFBackground: Lumen-apposing metal stents (LAMS) have displaced double-pigtail plastic stents (DPS) as the standard treatment for walled-off necrosis (WON),β but evidence for exclusively using LAMS is limited. We aimed to assess whether the theoretical benefit of LAMS was superior to DPS.
Methods: This multicenter, open-label, randomized trial was carried out in 9 tertiary hospitals.
Treatment failure occurs in about 25% of patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. We assessed whether cloxacillin plus fosfomycin achieves better treatment success than cloxacillin alone in hospitalized adults with MSSA bacteremia. We conducted a multicenter, open-label, phase III-IV superiority randomized clinical trial.
View Article and Find Full Text PDFAim: Vaccination against SARS-CoV2 has been proposed as a fundamental element for the control of the pandemic. This study aimed to describe the suspected adverse reactions (ADR) reported by vaccinated hospital workers.
Methods: A descriptive study of suspected ADR was conducted between January and March 2021.
Introduction: Methicillin-susceptible (MSSA) bacteraemia is a frequent condition, with high mortality rates. There is a growing interest in identifying new therapeutic regimens able to reduce therapeutic failure and mortality observed with the standard of care of beta-lactam monotherapy. In vitro and small-scale studies have found synergy between cloxacillin and fosfomycin against .
View Article and Find Full Text PDFSevere lung injury is triggered by both the SARS-CoV-2 infection and the subsequent host-immune response in some COVID-19 patients. We conducted a randomized, single-center, open-label, phase II trial with the aim to evaluate the efficacy and safety of methylprednisolone pulses and tacrolimus plus standard of care (SoC) vs. SoC alone, in hospitalized patients with severe COVID-19.
View Article and Find Full Text PDFBackground: We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and endocarditis.
Methods: A randomized (1:1) phase 3 superiority, open-label, and parallel group clinical trial of adult inpatients with MRSA bacteremia was conducted at 18 Spanish hospitals. Patients were randomly assigned to receive either 10 mg/kg of daptomycin intravenously daily plus 2 g of fosfomycin intravenously every 6 hours, or 10 mg/kg of daptomycin intravenously daily.
Article Synopsis
- Lumen-apposing metal stents (LAMS) are increasingly being used for treating pancreatic-fluid collections, specifically walled-off necrosis (WON), but their effectiveness over traditional plastic stents has not yet been established.
- This study is a randomized controlled trial involving 114 patients across nine hospitals in Spain, comparing the efficacy of LAMS to plastic stents in EUS-guided transmural drainage of WON, with a focus on short-term and long-term clinical success and safety.
- The goal of the PROMETHEUS trial is to provide clear evidence on whether LAMS provide superior treatment outcomes compared to plastic stents for patients with WON.
Objective: To assess participants' knowledge of key aspects about the clinical trials in which they are enrolled, describe the consent process, and assess the importance that investigators give to various aspects of trial information when verbally informing candidates.
Design: Prospective study based on a structured questionnaire interview of participants within 3 months after trial enrollment and an anonymous questionnaire sent to clinical trial investigators.
Subjects: A total of 140 participants included in 40 clinical trials were interviewed, and 51 investigators answered the questionnaire.