Neutrophil-Lymphocytes Ratio as Potential Early Marker for Alzheimer's Disease.

Background: Neutrophil-lymphocyte ratio (NLR) is a noninvasive, inexpensive, and easily applicable marker of inflammation. Since immune dysregulation leading to inflammation is regarded as a hallmark of dementia, in particular Alzheimer's disease (AD), we decided to investigate the potentials of NLR as a diagnostic and predictive biomarker in this clinical setting.

Materials And Methods: NLR was measured in the blood of patients with AD ( = 103), amnestic type mild cognitive impairment (aMCI,  = 212), vascular dementia (VAD,  = 34), and cognitively healthy Controls ( = 61).