Publications by authors named "Pietro Pignatta"
Article Synopsis
- The study aimed to identify factors that predict seizure recurrence in women of childbearing age with idiopathic generalized epilepsy (IGE) who switched from valproate (VPA) to alternative antiseizure medications (ASMs) like levetiracetam (LEV) and lamotrigine (LTG).
- Researchers evaluated data from 426 women across 16 epilepsy centers, finding that common reasons for switching medications included concerns about teratogenicity and that around a quarter of the women experienced worsening or recurrence of seizures within 12 and 24 months.
- The analysis revealed that LEV was associated with a lower risk of seizure recurrence or worsening compared to LTG, providing potential guidance for treatment options after VPA discontinuation.
