Structural Insights on the Role of Halogen Bonding in Protein MEK Kinase-Inhibitor Complexes.

Kinases are enzymes that play a critical role in governing essential biological processes. Due to their pivotal involvement in cancer cell signaling, they have become key targets in the development of anti-cancer drugs. Among these drugs, those containing the 2,4-dihalophenyl moiety demonstrated significant potential.

Pivotal role of the protein corona in the cell uptake of fluorinated nanoparticles with increased sensitivity for F-MR imaging.

cell tracking by non-invasive imaging technologies is needed to accelerate the clinical translation of innovative cell-based therapies. In this regard, F-MRI has recently gained increased attention for unbiased localization of labeled cells over time. To push forward the use of F-MRI for cell tracking, the development of highly performant F-probes is required.