[The study of drug resistance in aerobic and anaerobic bacterial flora to selected antibacterial drugs].

The aim of the study to determine the resistance to certain antibacterial drugs of the aerobic and anaerobic bacterial flora isolated from patients operated on for acute abdominal infections. The resistance was investigated by the disc diffusion method. Among the isolated aerobes Enterobacteriaceae, Enterococcus spp, Pseudomonas spp.

The value of quantitative bacteriological investigations in the monitoring of treatment of ischaemic ulcerations of lower legs.

The quantitative and qualitative bacteriological investigations of 63 patients were done on ischaemic ulcerations before reconstructive vascular surgery and at 7 day intervals after the operation. Among the isolated bacteria the most common were Gram positive (62.9%), especially Staphylococcus aureus.

[Aerobic and anaerobic bacterial flora in acute abdominal illnesses].

366 specinmens taken from patients suffering from acute abdominal illnesses who had undergone operations were examined. Bacterial pathogens were isolated from 318 specimens. Aerobic bacteria were isolated from 53.

[Characterization of Candida sp strains isolated from different clinical specimens in the years 1989-1993].

420 Candida sp. strains, which were isolated from the following specimens: vaginal secretions, throat swabs, urine, surgical specimen, nail specimen, sputum, semen, bile, skin, swab, pus were examined. On the basis of morphological and biochemical examinations it was established that in the above mentioned specimens are presented different species of Candida genus.

[Anaerobic bacteria in infections of lower limb ulcerations in patients with chronic atherosclerotic arterial occlusion].

In 76 patients with lower limb ulcerations in the course of atherosclerotic arterial occlusion, quantitative and quantitative bacteriological examinations, angiographic examinations and ultrasonographic measurements of pressures with simultaneous calculation of ankle/arm index were performed. At the same time the progression of ulceration healing was assessed after the operation. From the samples from four patients anaerobic bacteria were cultured: three times P.

[Utilization of enzymatic activity in strains of Candida isolated from the vagina for typing and evaluation of pathogenicity].

The study involved 255 strains of Candida isolated from vaginal secretions (194 with symptomatic mycosis and 61 from asymptomatic cases). Most frequently isolated species were Candida albicans, Candida krusei and Candida tropicalis. Determination of lipolytic properties at 30 degrees C and 37 degrees C and proteolytic abilities against albumin and casein permitted for differentiation of strains belonging to Candida albicans and remaining strains of other Candida species.

[Occurrence of Helicobacter pylori strains resistant to metronidazole].

This study describes results of in vitro examination of susceptibility to metronidazole of clinical strains of Helicobacter pylori isolated from patients with gastritis. The susceptibility was determined by disc diffusion test. H.

[Etiologic factors in acute inflammatory states of the abdominal cavity].

Three hundred and two samples of biological material from patients operated because of acute inflammatory states of abdominal cavity were investigated. Both aerobic and anaerobic bacteria were investigated. Among aerobic flora most frequently occurred enterococci, E.

[Effect of treatment with autologous staphylococcal vaccine on the course of the immunologic process].

In 18 patients with furunculosis and in 9 with chronic inflammation of upper respiratory tract, some cellular immunity parameters were tested. These were: phagocytosis index and bactericidal activity against leukocytes. Humoral immunity was also investigated by measurement of serum gammaglobulins.

[Characteristics of Salmonella strains isolated from different environments in the years 1982-1993].

The examination of Salmonella strains isolated from hospital patients and out-patients was performed. The results of sensitivity tests of strains isolated in Poland, and from patients of "Third World countries" were compared. In both groups were the strains caused nosocomial infections, which were resistant to Ampicillin and Chloramphenicol.

Epidemiological estimation of Pseudomonas aeruginosa strains isolated from different environments.

117 P. aeruginosa strains have been isolated from hospital material (vascular ward), from ambulatory patients, from lake water samples and from animal environment. The serological characters of the above strains, their phage--typing patterns, their capability of producing ONPG hydrolase were compared in order to find out the strain with identical features responsible for nosocomial infections and also to find endemic infections.

[Azoles. 34. Nitroimidazole derivatives and their antibacterial and fungicidal action].

Nitroimidazole derivatives 4a-4c, 5a-5c, 8a-8c and 9a-9c were synthesized by treating 4,5-dinitro- and 2-methyl-4,5-dinitroimidazole (1,2) or their silver salts [1.Ag,, 2.Ag) with chlorosubtituted phenacyl bromides 3a-3c, diethyl sulphate or ethyl iodide, allyl iodide and ethyl chloro-, azo- or bromoacetate.

[Perioperative preventive use of ciprofloxacin in patients with cancer of the larynx].

In comparative study of patients with laryngeal cancer, perioperative prophylaxis with ciprofloxacin was estimated. The drug was administered intravenously 200 mg twice daily, for five days to groups of 95 patients. Bacteriological examinations performed intraoperatively mostly revealed Gram-positive germs.

[Azoles. 27. Nitroimidazole derivatives, their antibacterial and fungicidal activity and electron affinity].

Nitroimidazole derivatives 3a-3g, 4a-4g and 5-8 were synthesized by treating 4,5-dinitro- and 2-methyl-4,5-dinitroimidazole (1,2) with phenacyl bromide, its p-substituted derivatives or epichlorohydrin. 1-(3-Chloro-2-hydroxypropyl)-4,5-dinitroimidazole (5) and its 2-methyl derivative 6 have been converted to imidazo-oxazoles 7 and 8 or amino imidazole derivatives 9-14 by the action of potassium carbonate or cyclic amines (pyrrolidine, piperidine, morpholine and N-methylpiperazine). Some of the newly synthesized nitroimidazole derivatives show antibacterial and fungicidal activity.

[Azoles. Part 5: On halogen-nitroindazole derivatives and their antibacterial properties (author's transl)].

The authors describe a modified procedure for the synthesis of the 3-halogenindazole derivatives 1--7 and of the 1-hydroxymethylindazole derivatives 8--14. The compounds 8--13 yield the corresponding 1-chloromethyl derivatives 15--20, and 23 is obtained from 3. The compounds 7--23 exert slight antibacterial effects.