Publications by authors named "Pieter-Jan Serneels"
Article Synopsis
- Recent research using single-cell RNA sequencing has revealed five distinct states of oligodendroglial cells, expanding beyond the previously recognized two types: oligodendrocyte precursor cells and oligodendrocytes.
- *This new classification enhances our understanding of oligodendroglia in health and disease, aiding comparisons across studies and different animal models.
- *Standardizing terminology and consolidating findings can help address remyelination failures and improve insights into myelin-related disorders like multiple sclerosis and Alzheimer's disease.*
The fast-ageing killifish has gained increasing attention as a promising gerontology model to study age-related processes and neurodegeneration. Interestingly, it is the first vertebrate model organism that shows physiological neuron loss at old age in its central nervous system (CNS), including its brain and retina. However, the fact that the killifish brain and retina are ever-growing tissues complicates studying neurodegenerative events in aged fish.
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