Publications by authors named "Pieter M Cory"
Article Synopsis
- - Tuberous Sclerosis Complex (TSC) stems from mutations in TSC1 or TSC2, resulting in overactivity of the mTORC1 pathway and causing multiple organ lesions, primarily affecting the lungs and kidneys.
- - Research indicates that TFEB, a protein linked to TSC, plays a crucial role in kidney disease; knocking out TFEB improves kidney health and survival in mouse models of TSC.
- - The study suggests that the effects of Rapamycin, a treatment for TSC, rely on TFEB and that the understanding of mTORC1 activity in TSC is evolving, potentially opening new therapeutic options.
