Publications by authors named "Pierre-Yves Blanchard"

Dyspnea testifies to profound suffering in patients and its relief is a priority for caregivers. This can be achieved by correcting causative disorders ("etiopathogenic" approach) or targeting the dyspnea itself ("symptomatic" approach), as is done for pain. Empathetic solicitude from caregivers has an intrinsic analgesic effect, but its effects on dyspnea have not been formally documented.

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  • The study investigates fluid intake in ICU patients at risk of negative outcomes due to excessive fluid balance, highlighting the need for fluid optimization beyond traditional resuscitation.
  • Conducted across multiple ICUs in France and Spain, it recorded the types and volumes of fluids administered to patients needing vasopressors or invasive ventilation over a 24-hour period.
  • Results indicate that only 36% of the total fluid volume was essential for body fluid homeostasis, with significant variations in fluid administration based on the specific ICU, suggesting a strong center effect on fluid management practices.
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Aims: As a prerequisite of a multicentre study, we conducted a pilot study to assess the feasibility of a daily repositioning schedule in critically ill patients. The schedule was adapted to the patient's clinical condition, and the estimated risk for developing a pressure ulcer using the Braden scale.

Design: A single-center pre and post-intervention pilot study in a French Intensive Care Unit of a university teaching hospital.

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Introduction: At the beginning of 2020, a public health emergency was declared in France following the emergence of the SARS-CoV-2 pandemic.

Context: Nurses involved in an advanced practice mobilized their specific skills during this health crisis by drawing on the available resources.

Objectives: To analyze personal resources used by those nurses in the process of skill mobilization during the pandemic.

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  • A variety of polycyclic aromatic compounds, including naphthalene, phenanthrene, and coronene, were attached to carbon nanotube (CNT) electrodes through π stacking.
  • The electro-oxidation of these compounds in aqueous solutions produced quinones, which were then studied for their ability to facilitate electron transfer.
  • Specifically, the performance of these quinones was assessed while interacting with FAD-dependent glucose dehydrogenase in the process of catalyzing glucose oxidation.
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The setting up of an advanced practice nursing activity to monitor patients with severe or very severe pneumonia associated with Severe Acute Respiratory Syndrome Coronavirus 2, is a reponse to the population's new health care needs and a massive influx of patients. The skills of the advanced practice nurse are mobilised in this context in order to carry out prevention missions and screening for potential sequelae which could lead to chronic respiratory failure.

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Purpose: Flexible fiberoptic bronchoscopy is frequently used in intensive care unit, but is a source of discomfort, dyspnea and anxiety for patients. Our objective was to assess the feasibility and tolerance of a sedation using remifentanil target-controlled infusion, to perform fiberoptic bronchoscopy in awake ICU patients.

Materials, Patients And Methods: This monocentric, prospective observational study was conducted in awake patients requiring fiberoptic bronchoscopy.

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Electroreduction of diazonium salts is a widely used technique for grafting organic films on various surfaces. In this paper, scanning electrochemical microscopy (SECM) was used for high-resolution characterization of a thiolated aryl multilayer film obtained by electrografting of thiophenol diazonium on highly ordered pyrolytic graphite (HOPG). The blocking properties of the film were evaluated, and the origins of incomplete surface passivation were elucidated by comparing current-distance curves and surface reactivity maps obtained with nanometer- and micrometer-sized tips.

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We report on imaging of local electric field on an electrode surface with plasmonic electrochemical impedance microscopy (P-EIM). The local electric field is created by putting an electrode inside a micropipet positioned over the electrode and applying a voltage between the two electrodes. We show that the distribution of the surface charge as well as the local electric field at the electrode surface can be imaged with P-EIM.

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Molecular grafting of diazonium is a widely employed surface modification technique. Local electrografting of this species is a promising approach to surface doping and related properties tailoring. The instability of diazonium cation complicates this process, so that this species was generated in situ in many reported studies.

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Unlike macroscopic and micrometer-sized solid electrodes whose surface can be reproducibly cleaned by mechanical polishing, cleaning the nanoelectrode surface is challenging because of its small size and extreme fragility. Even very gentle polishing typically changes the nanoelectrode size and geometry, thus, complicating the replication of nanoelectrochemical experiments. In this letter, we show the possibility of cleaning nanoelectrode surfaces nondestructively by using an air plasma cleaner.

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Electrocatalytic behavior of TEMPO derivative SAMs on gold has been studied in the presence of benzyl alcohol. The results demonstrate that interfacial activity of the SAMs can be enhanced by diluting the TEMPO moiety with an alkyl passive matrix. The absolute catalytic activity exhibits a maximum for an intermediate value of the surface coverage of catalytic centers.

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Electrochemical transduction without covalent links between redox and complexant units in a complexing self-assembled monolayer has been established. The results demonstrate that transduction depends on the crown ether/ferrocene ratio and appears to be tunable.

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The elaboration of mixed self-assembled monolayers (SAMs) of tetrathiafulvalene derivatives allows the modulation of intermolecular interactions and provides evidence of segregated distribution of redox centers.

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