Publications by authors named "Pierre-Antoine Dupont"
Article Synopsis
- ApoE mice serve as a model for studying atherosclerosis, with a focus on the effects of a Western diet and uremia.
- Five groups of mice were analyzed based on their diet and kidney conditions, and various imaging and histological methods were utilized to assess atherosclerosis.
- While immunostaining revealed greater inflammation in ApoE mice compared to control mice, with a Western diet showing stronger effects, F-FDG PET-MR imaging did not indicate any increased glucose uptake in the aortas of the different ApoE groups.
Background: Metabolic imaging is routinely used to demonstrate aortitis in patients with giant-cell arteritis. We aimed to investigate the preclinical model of aortitis in BALB/c IL1rn mice using [F]fluorodeoxyglucose ([F]FDG) positron emission tomography-magnetic resonance (PET-MR), gamma counting and immunostaining. We used 15 first-generation specific and opportunistic pathogen-free (SOPF) 9-week-old IL1rn mice, 15 wild-type BALB/cAnN mice and 5 s-generation specific pathogen-free (SPF) 9-week-old IL1rn.
View Article and Find Full Text PDF