Impact of disposable syringes type choice on myocardial perfusion imaging procedures with [Tc]Tc-tetrofosmin.

Background: Residual activity in dispensing syringes is a problem that has been sporadically reported with various radiopharmaceuticals. Studies with [Tc]Tc-tetrofosmin are non-consistent so far. The aim was to quantify the residual activity of [Tc]Tc-tetrofosmin in different syringes in a clinical setting and to assess its impact on the clinical imaging procedure.

Revisiting detection of in-transit metastases in melanoma patients using digital F-FDG PET/CT with small-voxel reconstruction.

Aim: To evaluate the use of digital F-FDG PET/CT with small-voxels reconstruction for detecting in-transit metastases in melanoma patients with primary lesion located on the upper or lower limbs, in comparison with standard reconstruction and European Association of Nuclear Medicine Research limited (EARL)-compliant reconstruction mimicking former generation PET systems.

Methods: Forty-six PET examinations acquired in list mode on a Vereos digital PET/CT system were reconstructed with (1) the standard reconstruction [2 iterations, 10 subsets (2i10s), point-spread function (PSF) modelling and time-of-flight enabled, no post-filtering and voxel size of 2 mm], (2) a small-voxel reconstruction using 1 mm voxels otherwise using the same parameters, (3) an EARL-compliant reconstruction mimicking a former generation system. Comparison of results across these reconstructions was made for a blind randomized review using a 3-point scale for the presence of in-transit metastases and image quality as well as for tumour-to-background (T/B) ratios and noise level in reference organs.