Publications by authors named "Pierre-Ambroise Caquot"

Article Synopsis
  • The study investigates the role of the cerebellum-to-liver uptake ratio (CLIP) as a prognostic factor for patients with post-transplant lymphoproliferative disorders (PTLD), in addition to the International Prognostic Index (IPI) score.
  • A total of 97 PTLD patients were analyzed, revealing that both a higher IPI score (≥ 3) and lower CLIP (< 3.24) correlated with poorer progression-free survival (PFS) outcomes.
  • While CLIP shows potential as a predictor for PFS, its association with overall survival (OS) was not statistically significant, indicating that further research is needed to validate these findings.
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Objective: From patient and phantom studies, we aimed to highlight an original implementation process and share a two-years experience clinical feedback on xSPECT (xS), xSPECT Bone (xB) and Broadquant quantification (Siemens) for Tc-bone and Lu-NET (neuroendocrine tumors) imaging.

Methods: Firstly, we checked the relevance of implemented protocols and Broadquant module on the basis of literature and with a homogeneous phantom study respectively. Then, we described xS and xB behaviours with reconstruction parameters (10i-0mm to 40i-20mm) and optimized the protocols through a blinded survey (7 physicians).

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Post-transplant lymphoproliferative disorder (PTLD) is a rare complication of immunosuppression. Sequential treatment is commonly proposed, combining induction with rituximab (R-induction) followed by either continuation of treatment or addition of chemotherapy depending on response. Response to R-induction, often assessed by CT scan, is a major predictor of overall survival (OS).

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We report the case of a 55-year-old man presenting pseudopsychiatric behavior disorders of subacute-onset. MRI showed a FLAIR (fluid-attenuated inversion recovery) hyperintensity in the left hippocampus. The diagnosis of limbic encephalitis was raised, and the patient was referred for an 18F-FDG PET/CT.

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