Publications by authors named "Pierre Yves Egreteau"
Background: Response to prophylactic platelet transfusion is suspected to be inconsistent in critically ill patients questioning how to optimize transfusion practices. This study aimed to describe prophylactic platelet transfusion response, to identify factors associated with a suboptimal response, to analyse the correlation between corrected count increment and platelet count increment and to determine the association between poor platelet transfusion response and clinical outcomes.
Methods: This prospective multicentre observational study recruited patients who received at least one prophylactic platelet transfusion in one of the nine participating intensive care units for a period up to 16 months.
Article Synopsis
- Patients with severe COVID-19 in ICUs have a high risk of blood clots, prompting a study to compare the effects of intermediate-dose versus standard-dose anticoagulation.
- The study included 1,174 patients and found no significant difference in 90-day mortality or ICU stay length between the two dosing groups, but intermediate-dose patients had fewer venous thrombo-embolism (VTE) incidents.
- Both groups experienced similar rates of bleeding complications, indicating that while the doses impacted blood clot rates, they did not affect overall survival or safety.
Background: Fasting is frequently imposed before extubation in patients in intensive care units, with the aim to reduce risk of aspiration. This unevaluated practice might delay extubation, increase workload, and reduce caloric intake. We aimed to compare continued enteral nutrition until extubation with fasting before extubation in patients in the intensive care unit.
View Article and Find Full Text PDFBackground: Dexamethasone is recommended for COVID-19 patients who require oxygen therapy. However, its effectiveness in reducing mortality and intubation, and its safety, remain debated. We aimed to investigate whether dexamethasone reduces day-28 mortality in unselected patients with critical COVID-19.
View Article and Find Full Text PDFBackground: Among strategies that aimed to prevent acquired infections (AIs), selective decontamination regimens have been poorly studied in the COVID-19 setting. We assessed the impact of a multiple-site decontamination (MSD) regimen on the incidence of bloodstream infections (BSI) and ventilator-associated pneumonia (VAP) in COVID-19 patients receiving mechanical ventilation.
Methods: We performed an ancillary analysis of a multicenter retrospective observational study in 15 ICUs in western France.
Rationale: Early corticosteroid treatment is used to treat COVID-19-related acute respiratory distress syndrome (ARDS). Infection is a well-documented adverse effect of corticosteroid therapy.
Objectives: To determine whether early corticosteroid therapy to treat COVID-19 ARDS was associated with ventilator-associated pneumonia (VAP).
Introduction: Expanded-criteria donors (ECDs) are used to reduce the shortage of kidneys for transplantation. However, kidneys from ECDs are associated with an increased risk of delayed graft function (DGF), a risk factor for allograft loss and mortality. HYPOREME will be a multicentre randomised controlled trial (RCT) comparing targeted hypothermia to normothermia in ECDs, in a country where the use of machine perfusion for organ storage is the standard of care.
View Article and Find Full Text PDFIntroduction: The use of sedation in intensive care units (ICUs) is necessary and ubiquitous. The impact of sedation strategy on outcome, particularly when delivered early after initiation of mechanical ventilation, is unknown. Evidence is increasing that volatile anaesthetic agents could be associated with better outcome.
View Article and Find Full Text PDFArticle Synopsis
- Fluid management is crucial in treating sepsis and septic shock, with studies showing mixed results on the impact of chloride-rich fluids like normal saline on kidney health.
- This study looked at 239 septic shock patients to see if high chloride intake (>18g in the first 48 hours) affected acute kidney injury (AKI) and other health outcomes.
- Findings revealed no significant link between high chloride doses and kidney function deterioration, ICU stay length, or mortality rates, suggesting high chloride administration is safe in the early treatment phase.
Objectives: To determine the frequency and prognosis of invasive pulmonary aspergillosis in critically ill patients with severe influenza pneumonia.
Design: Retrospective multicenter cohort study.
Setting: Five French ICUs.
Background: Fluid infusion represents one of the cornerstones of resuscitation therapies in order to increase oxygen delivery during septic shock. Fluid overload as a consequence of excessive fluid administration seems to be linked to worse long-term outcome. However, its immediate effect on patient's clinical state is poorly described.
View Article and Find Full Text PDFPurpose: Intubation of hypoxemic patients is associated with life-threatening adverse events. High-flow therapy by nasal cannula (HFNC) for preoxygenation before intubation has never been assessed by randomized study. Our objective was to evaluate the efficiency of HFNC for preoxygenation, compared to high fraction-inspired oxygen facial mask (HFFM).
View Article and Find Full Text PDFObjectives: The aim of this study was to highlight the link between induced hypothermia and increased survival duration as observed in the septic model developed by the laboratory. To reach this objective, survival duration and blood oxygen transport capacity were measured at two temperatures-38 °C (induced normothermia) and 34 °C (induced hypothermia)-in septic rats.
Design: A prospective, randomized, experimental animal study.