Publications by authors named "Pierre Schneider"
Recently, a novel group of CD34+ and S100+ spindle cell tumors with distinctive stromal and perivascular hyalinization showing recurrent gene fusions involving RAF1, BRAF, NTRK1/2/3, and RET has been identified. ALK rearrangements have been rarely reported in this group of tumors. We report a 24-year-old woman with a 1.
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- * The study examined 313 MMP patients, identifying those who were treated with gliptins to see if there was a connection to the onset of MMP.
- * Findings showed that patients who stopped using gliptins had a higher rate of remission, while one patient who resumed treatment experienced a relapse, highlighting differences in symptoms and severity compared to MMP patients not treated with gliptins.
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- * Among 70 patients, 97% experienced a significant rise in creatinine levels after starting Vemurafenib, but levels returned to normal after discontinuation in most cases.
- * The increase in creatinine was linked to both the inhibition of creatinine tubular secretion and some impairment of renal function, but since this increase is usually reversible, treatment should not be stopped if Vemurafenib is effective.
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- Systemic steroids, sometimes combined with cyclosporin, are typically prescribed for severe cases of Pyoderma gangrenosum (PG).
- A 27-year-old woman with a long history of Crohn's disease experienced a serious and widespread PG that didn't respond to various treatments.
- The addition of certolizumab pegol, along with steroids and tacrolimus, led to her complete recovery from PG, suggesting it could be a viable treatment option when other anti-TNF therapies aren't effective or tolerated.
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- Ipilimumab, an antibody approved for treating metastatic melanoma in Europe, was studied in a retrospective analysis involving patients with advanced melanoma previously treated with chemotherapy.
- The study included 45 patients, revealing a 13% best overall response rate and a median overall survival of 8 months, with brain metastases not significantly impacting survival outcomes.
- Factors like baseline corticosteroid use and high LDH levels negatively affected overall survival, indicating that certain patient subsets may benefit more from ipilimumab treatment.
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- Biological agents have improved the treatment of inflammatory and proliferative disorders, but concerns about safety, including a higher risk of infections and secondary cancers, have emerged.! -
- The report examines four cases where melanoma worsened or developed after rituximab treatment for B-cell lymphoma, noting rapid progression in three cases previously diagnosed with melanoma.! -
- While it's too soon to definitively link rituximab to the development of melanoma, ongoing monitoring and documentation of such instances is essential for better understanding the potential risks.!
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- * The study found that overall response rates were 53%, with a median overall survival (OS) of 7.5 months and progression-free survival (PFS) of 3.6 months, even among patients with brain metastases, who had a 50% response rate.
- * Common side effects included fatigue, joint pain, and skin issues, with 16% of patients developing squamous cell carcinoma; however, the toxicity was deemed manageable, confirming the drug
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- A study analyzed skin squamous cell carcinoma (SCC) in kidney transplant recipients, focusing on the origin of tumor cells and mutations in the p53 gene.
- Researchers found that in one patient, skin tumor cells had a donor genotype and a specific TP53 mutation, indicating a donor contribution to skin cancer.
- These results highlight the potential risks of cancer development due to prolonged immunosuppression in kidney transplant patients and emphasize the need for careful monitoring.
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- Recent reports have identified two cases of neutrophilic panniculitis in patients treated with vemurafenib, with no signs of immune or infectious causes.
- Despite the side effect, treatment was continued due to positive tumor responses, indicating that physicians should be aware of this issue but not necessarily stop the therapy.
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- M. chelonae is a rare but known cause of nodular lymphangitis.* -
- Two cases of nodular lymphangitis linked to M. chelonae were reported in patients with weakened immune systems.* -
- Both patients responded well to antibiotic treatment, successfully clearing the infection.*
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- Pagetoid proliferation of melanocytes can appear in various skin conditions, including specific types of nevi and melanoma, making differentiation challenging due to clinical and histological similarities.
- A study analyzing 24 cases involved three expert dermatopathologists who rated the severity of these conditions, revealing a high agreement in 71% of cases but notable discrepancies in 29%.
- Fluorescence in-situ hybridization (FISH) was effective in diagnosing melanoma, correctly identifying malignancy in most cases diagnosed as such, while showing potential in cases deemed indeterminate.