Publications by authors named "Pierre Saramito"
Article Synopsis
- Downstream of gene expression, actomyosin contractile machinery plays a crucial role in embryo morphogenesis, specifically during Drosophila embryonic axis extension where it enables oriented cell intercalation and tissue deformation through organized planar polarity.
- The study presents a new numerical model that simulates the dynamics of the actomyosin-rich epithelial surface across the whole embryo, factoring in specific contractility patterns to predict tissue strain rates and displacements during development.
- The model’s predictions align with experimental observations, demonstrating that the anisotropic contractility in the ventro-lateral region directly influences whole-tissue deformations, highlighting the importance of the embryo’s geometry and the cephalic furrow in understanding these developmental processes.
The understanding of morphogenesis in living organisms has been renewed by tremendous progress in experimental techniques that provide access to cell scale, quantitative information both on the shapes of cells within tissues and on the genes being expressed. This information suggests that our understanding of the respective contributions of gene expression and mechanics, and of their crucial entanglement, will soon leap forward. Biomechanics increasingly benefits from models, which assist the design and interpretation of experiments, point out the main ingredients and assumptions, and ultimately lead to predictions.
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